U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Eif2s3y eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked [ Mus musculus (house mouse) ]

Gene ID: 26908, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Eif2s3yprovided by MGI
Official Full Name
eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linkedprovided by MGI
Primary source
MGI:MGI:1349430
See related
Ensembl:ENSMUSG00000069049 AllianceGenome:MGI:1349430
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Spy; Tfy; Eif-2gy
Summary
Predicted to enable translation initiation factor activity. Predicted to contribute to tRNA binding activity. Predicted to be involved in formation of translation preinitiation complex and positive regulation of translational fidelity. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic translation initiation factor 2 complex. Is expressed in several structures, including brain; genitourinary system; heart; liver; and lung. Human ortholog(s) of this gene implicated in MEHMO syndrome. Orthologous to human EIF2S3 (eukaryotic translation initiation factor 2 subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 11.4), CNS E14 (RPKM 7.7) and 17 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
Y; Ypter
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) Y NC_000087.8 (1010562..1049136)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) Y NC_000087.7 (1010562..1049134)

Chromosome Y - NC_000087.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_48294 Neighboring gene lysine demethylase 5D Neighboring gene STARR-seq mESC enhancer starr_48295 Neighboring gene STARR-seq mESC enhancer starr_48296 Neighboring gene nuclear encoded rRNA 5S 1 Neighboring gene STARR-seq mESC enhancer starr_48297 Neighboring gene STARR-seq mESC enhancer starr_48298 Neighboring gene testis specific protein-Y encoded, pseudogene Neighboring gene ubiquitously transcribed tetratricopeptide repeat containing, Y-linked

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Eif2s3y alleviated LPS-induced damage to mouse testis and maintained spermatogenesis by negatively regulating Adamts5.
    Title: Eif2s3y alleviated LPS-induced damage to mouse testis and maintained spermatogenesis by negatively regulating Adamts5.
  2. The Role of Eif2s3y in Mouse Spermatogenesis and ESC.
    Title: The Role of Eif2s3y in Mouse Spermatogenesis and ESC.
  3. Eif2s3y regulates the proliferation of spermatogonial stem cells via Wnt6/<beta>-catenin signaling pathway.
    Title: Eif2s3y regulates the proliferation of spermatogonial stem cells via Wnt6/<beta>-catenin signaling pathway.
  4. Study highlighted novel roles of EIF2S3Y in the pluripotency maintenance and proliferation control of ES cells, which would provide an efficient model to study germ cell generation as well as cancer development using ES cells.
    Title: EIF2S3Y suppresses the pluripotency state and promotes the proliferation of mouse embryonic stem cells.
  5. Eif2s3y can be replaced by transgenic overexpression of its X chromosome-encoded homolog Eif2s3x. This finding supports the existence of functional redundancy between the Y chromosome genes and their homologs encoded on other chromosomes.
    Title: Two genes substitute for the mouse Y chromosome for spermatogenesis and reproduction.
  6. this study demonstrates that live mouse progeny can also be generated by using germ cells from males with the Y chromosome contribution limited to only two genes, the testis determinant factor Sry and the spermatogonial proliferation factor Eif2s3y.
    Title: Two Y genes can replace the entire Y chromosome for assisted reproduction in the mouse.
  7. Data from knockout mice suggest that spermiogenesis can be initiated whether or not second meiotic division has taken place, and even when the only Y genes present are Eif2s3y and Sry.
    Title: Spermatid development in XO male mice with varying Y chromosome short-arm gene content: evidence for a Y gene controlling the initiation of sperm morphogenesis.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in formation of translation preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within translational initiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of eukaryotic translation initiation factor 2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
eukaryotic translation initiation factor 2 subunit 3, Y-linked
Names
eIF-2-gamma Y
eukaryotic translation initiation factor 2 subunit gamma, Y-linked
spermatogenesis Y
spermatogonial proliferation factor
NP_001344023.1
NP_036141.1
XP_006531673.1
XP_011246895.1
XP_030107429.1
XP_036018085.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357094.1 → NP_001344023.1  eukaryotic translation initiation factor 2 subunit 3, Y-linked isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon, resulting in a novel 5' UTR and the use of a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC145392
    UniProtKB/TrEMBL
    Q3U5H6
    Conserved Domains (1) summary
    PTZ00327
    Location:1 → 287
    PTZ00327; eukaryotic translation initiation factor 2 gamma subunit; Provisional

  2. NM_012011.2 → NP_036141.1  eukaryotic translation initiation factor 2 subunit 3, Y-linked isoform 1

    See identical proteins and their annotated locations for NP_036141.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC145392, AI661184, AK009448, BY711372
    Consensus CDS
    CCDS30542.1
    UniProtKB/Swiss-Prot
    Q9Z0N2
    UniProtKB/TrEMBL
    Q9D791
    Related
    ENSMUSP00000088736.4, ENSMUST00000091197.4
    Conserved Domains (4) summary
    cd01888
    Location:42 → 248
    eIF2_gamma; Gamma subunit of initiation factor 2 (eIF2 gamma)
    PTZ00327
    Location:13 → 466
    PTZ00327; eukaryotic translation initiation factor 2 gamma subunit; Provisional
    cd03688
    Location:249 → 362
    eIF2_gamma_II; Domain II of the gamma subunit of eukaryotic translation initiation factor 2
    cd15490
    Location:365 → 459
    eIF2_gamma_III; Domain III of eukaryotic initiation factor eIF2 gamma

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000087.8 Reference GRCm39 C57BL/6J

    Range
    1010562..1049136
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251569.2 → XP_030107429.1  eukaryotic translation initiation factor 2 subunit 3, Y-linked isoform X3

    UniProtKB/TrEMBL
    Q3U5H6
    Conserved Domains (1) summary
    PTZ00327
    Location:1 → 273
    PTZ00327; eukaryotic translation initiation factor 2 gamma subunit; Provisional

  2. XM_011248593.3 → XP_011246895.1  eukaryotic translation initiation factor 2 subunit 3, Y-linked isoform X1

    See identical proteins and their annotated locations for XP_011246895.1

    UniProtKB/TrEMBL
    Q3UDF8
    Conserved Domains (1) summary
    PTZ00327
    Location:13 → 452
    PTZ00327; eukaryotic translation initiation factor 2 gamma subunit; Provisional

  3. XM_036162192.1 → XP_036018085.1  eukaryotic translation initiation factor 2 subunit 3, Y-linked isoform X1

    UniProtKB/TrEMBL
    Q3UDF8
    Conserved Domains (1) summary
    PTZ00327
    Location:13 → 452
    PTZ00327; eukaryotic translation initiation factor 2 gamma subunit; Provisional

  4. XM_006531610.4 → XP_006531673.1  eukaryotic translation initiation factor 2 subunit 3, Y-linked isoform X2

    See identical proteins and their annotated locations for XP_006531673.1

    UniProtKB/TrEMBL
    Q3U5H6
    Conserved Domains (1) summary
    PTZ00327
    Location:1 → 287
    PTZ00327; eukaryotic translation initiation factor 2 gamma subunit; Provisional

RNA

  1. XR_004940598.1 RNA Sequence

  2. XR_879402.4 RNA Sequence

  3. XR_004940597.1 RNA Sequence

  4. XR_004940596.1 RNA Sequence

  5. XR_003953252.1 RNA Sequence

  6. XR_001782883.2 RNA Sequence

  7. XR_001782884.2 RNA Sequence

  8. XR_001782885.2 RNA Sequence

  9. XR_001782886.2 RNA Sequence

  10. XR_388245.2 RNA Sequence

  11. XR_001782887.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z0N2.2 GenPept UniProtKB/Swiss-Prot:Q9Z0N2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous