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Capn11 calpain 11 [ Mus musculus (house mouse) ]

Gene ID: 268958, updated on 11-Apr-2024

Summary

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Official Symbol
Capn11provided by MGI
Official Full Name
calpain 11provided by MGI
Primary source
MGI:MGI:1352490
See related
Ensembl:ENSMUSG00000058626 AllianceGenome:MGI:1352490
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable calcium-dependent cysteine-type endopeptidase activity. Predicted to be involved in proteolysis. Located in acrosomal vesicle. Is expressed in spermatocyte and testis. Orthologous to human CAPN11 (calpain 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 8.5), cerebellum adult (RPKM 1.0) and 1 other tissue See more
Orthologs
human all
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Genomic context

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See Capn11 in Genome Data Viewer
Location:
17 C; 17 22.59 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (45941117..45970400, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (45630191..45659709, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42635 Neighboring gene STARR-seq mESC enhancer starr_42636 Neighboring gene myomixer, myoblast fusion factor Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:45756550-45756733 Neighboring gene predicted gene, 52283 Neighboring gene STARR-positive B cell enhancer ABC_E9955 Neighboring gene predicted gene, 25008 Neighboring gene STARR-positive B cell enhancer ABC_E10956 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:45775877-45776144 Neighboring gene transmembrane protein 63b Neighboring gene STARR-positive B cell enhancer ABC_E7534 Neighboring gene mitochondrial ribosomal protein L14 Neighboring gene predicted gene, 35456

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Calpain-cleaved collapsin response mediator protein-3 induces neuronal death after glutamate toxicity and cerebral ischemia. Hou ST, et al. J Neurosci, 2006 Feb 22. PMID 16495451, Free PMC Article
  2. Calpain 11 is unique to mouse spermatogenic cells. Ben-Aharon I, et al. Mol Reprod Dev, 2006 Jun. PMID 16541461, Free PMC Article
  3. Diverse mRNA expression patterns of the mouse calpain genes Capn5, Capn6 and Capn11 during development. Dear TN, et al. Mech Dev, 1999 Dec. PMID 10559499
  4. Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice. Miyata H, et al. Proc Natl Acad Sci U S A, 2016 Jul 12. PMID 27357688, Free PMC Article
  5. In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype. Gineste C, et al. Neuromuscul Disord, 2013 Apr. PMID 23375831

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium-dependent cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in acrosomal vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
calpain-11
Names
CANP 11
calcium-activated neutral proteinase 11
calcium-dependent thiol protease
NP_001013789.1
XP_011244781.1
XP_011244782.1
XP_017172975.1
XP_017172976.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013767.2 → NP_001013789.1  calpain-11

    See identical proteins and their annotated locations for NP_001013789.1

    Status: PROVISIONAL

    Source sequence(s)
    AC165259
    Consensus CDS
    CCDS50121.1
    UniProtKB/Swiss-Prot
    Q6J756
    Related
    ENSMUSP00000113132.2, ENSMUST00000120717.8
    Conserved Domains (3) summary
    cd00051
    Location:591 → 641
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00648
    Location:56 → 352
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:367 → 520
    Calpain_III; Calpain large subunit, domain III

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    45941117..45970400 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246479.4 → XP_011244781.1  calpain-11 isoform X1

    Conserved Domains (3) summary
    cd16193
    Location:586 → 753
    EFh_PEF_CAPN11; Penta-EF hand, calcium binding motifs, found in calpain-11 (CAPN11)
    pfam00648
    Location:95 → 391
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:413 → 559
    Calpain_III; Calpain large subunit, domain III

  2. XM_017317486.2 → XP_017172975.1  calpain-11 isoform X3

    Conserved Domains (3) summary
    cd16193
    Location:255 → 422
    EFh_PEF_CAPN11; Penta-EF hand, calcium binding motifs, found in calpain-11 (CAPN11)
    pfam01067
    Location:82 → 228
    Calpain_III; Calpain large subunit, domain III
    cl00051
    Location:44 → 66
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.

  3. XM_011246480.4 → XP_011244782.1  calpain-11 isoform X2

    Conserved Domains (2) summary
    cd00214
    Location:405 → 492
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    pfam00648
    Location:95 → 391
    Peptidase_C2; Calpain family cysteine protease

  4. XM_017317487.3 → XP_017172976.1  calpain-11 isoform X4

    Conserved Domains (1) summary
    pfam00648
    Location:95 → 374
    Peptidase_C2; Calpain family cysteine protease

RNA

  1. XR_876510.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6J756.1 GenPept UniProtKB/Swiss-Prot:Q6J756

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