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Pkmyt1 protein kinase, membrane associated tyrosine/threonine 1 [ Mus musculus (house mouse) ]

Gene ID: 268930, updated on 11-Apr-2024

Summary

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Official Symbol
Pkmyt1provided by MGI
Official Full Name
protein kinase, membrane associated tyrosine/threonine 1provided by MGI
Primary source
MGI:MGI:2137630
See related
Ensembl:ENSMUSG00000023908 AllianceGenome:MGI:2137630
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Myt1; 6230424P17
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in meiotic cell cycle. Predicted to act upstream of or within phosphorylation. Located in cytoplasm and nucleus. Is expressed in several structures, including brain ventricular layer; early embryo; oocyte; retina; and thymus primordium. Orthologous to human PKMYT1 (protein kinase, membrane associated tyrosine/threonine 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 44.6), testis adult (RPKM 32.4) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 A3.3; 17 12.02 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (23945385..23955709)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (23726336..23736735)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene claudin 9 Neighboring gene glycine rich extracellular protein 1 Neighboring gene progestin and adipoQ receptor family member IV Neighboring gene kringle containing transmembrane protein 2 Neighboring gene RIKEN cDNA 9530082P21 gene Neighboring gene FLYWCH-type zinc finger 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Protein tyrosine kinase Wee1B is essential for metaphase II exit in mouse oocytes. Oh JS, et al. Science, 2011 Apr 22. PMID 21454751, Free PMC Article
  2. Wee1B, Myt1, and Cdc25 function in distinct compartments of the mouse oocyte to control meiotic resumption. Oh JS, et al. J Cell Biol, 2010 Jan 25. PMID 20083600, Free PMC Article
  3. Single-cell transcriptomic analysis of mouse neocortical development. Loo L, et al. Nat Commun, 2019 Jan 11. PMID 30635555, Free PMC Article
  4. The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Ray JP, et al. Immunity, 2015 Oct 20. PMID 26410627, Free PMC Article
  5. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ELF3 promotes gemcitabine resistance through PKMYT1/CDK1 signaling pathway in gallbladder cancer.
    Title: ELF3 promotes gemcitabine resistance through PKMYT1/CDK1 signaling pathway in gallbladder cancer.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of G2/MI transition of meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
Names
MYT1 kinase
NP_001405406.1
NP_001405409.1
NP_001405413.1
NP_001405414.1
NP_001405456.1
NP_001405457.1
NP_001405458.1
NP_075545.2
XP_006524373.1
XP_006524374.1
XP_030105683.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418477.1 → NP_001405406.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC122821

  2. NM_001418480.1 → NP_001405409.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC122821

  3. NM_001418484.1 → NP_001405413.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC122821

  4. NM_001418485.1 → NP_001405414.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC122821

  5. NM_001418527.1 → NP_001405456.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC122821

  6. NM_001418528.1 → NP_001405457.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC122821

  7. NM_001418529.1 → NP_001405458.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC122821

  8. NM_023058.4 → NP_075545.2  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 1

    See identical proteins and their annotated locations for NP_075545.2

    Status: VALIDATED

    Source sequence(s)
    AC122821
    Consensus CDS
    CCDS28460.1
    UniProtKB/Swiss-Prot
    Q3TNN2, Q8R3L4, Q9ESG9
    Related
    ENSMUSP00000024701.8, ENSMUST00000024701.9
    Conserved Domains (2) summary
    smart00220
    Location:101 → 350
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14050
    Location:99 → 348
    PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    23945385..23955709
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524310.4 → XP_006524373.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1

    Conserved Domains (1) summary
    cd14050
    Location:148 → 397
    PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1

  2. XM_006524311.5 → XP_006524374.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X2

    Conserved Domains (1) summary
    cd14050
    Location:148 → 397
    PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1

  3. XM_030249823.2 → XP_030105683.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:1 → 216
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ESG9.3 GenPept UniProtKB/Swiss-Prot:Q9ESG9

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