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mapk14b mitogen-activated protein kinase 14b [ Danio rerio (zebrafish) ]

Gene ID: 266756, updated on 27-Mar-2024

Summary

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Official Symbol
mapk14bprovided by ZNC
Official Full Name
mitogen-activated protein kinase 14bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-021007-1
See related
Ensembl:ENSDARG00000028721 AllianceGenome:ZFIN:ZDB-GENE-021007-1
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
p38b; zp38b; MAPK14
Summary
Predicted to enable MAP kinase activity. Predicted to be involved in several processes, including p38MAPK cascade; positive regulation of cell differentiation; and positive regulation of myoblast fusion. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm and nucleus. Orthologous to human MAPK14 (mitogen-activated protein kinase 14). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See mapk14b in Genome Data Viewer
Location:
chromosome: 11
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (2710499..2760373)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (2641137..2691019)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene si:ch211-160o17.6 Neighboring gene transmembrane protein 167B Neighboring gene SRSF protein kinase 1b Neighboring gene LHFPL tetraspan subfamily member 5a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Cold-induced retrotransposition of fish LINEs. Chen S, et al. J Genet Genomics, 2017 Aug 20. PMID 28869113
  2. Sodium fluoride affects zebrafish behaviour and alters mRNA expressions of biomarker genes in the brain: Role of Nrf2/Keap1. Mukhopadhyay D, et al. Environ Toxicol Pharmacol, 2015 Sep. PMID 26245810
  3. Zebrafish as a Model to Unveil the Pro-Osteogenic Effects of Boron-Vitamin D3 Synergism. Sojan JM, et al. Front Nutr, 2022. PMID 35571926, Free PMC Article
  4. The role of Nrf2 and MAPK pathways in PFOS-induced oxidative stress in zebrafish embryos. Shi X, et al. Toxicol Sci, 2010 Jun. PMID 20200220
  5. Fishing the molecular bases of Treacher Collins syndrome. Weiner AM, et al. PLoS One, 2012. PMID 22295061, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mitogen-activated protein kinase 14B
Names
MAP kinase 14B
MAP kinase p38b
MAPK 14B
mitogen-activated protein kinase p38b
NP_001300688.1
XP_017213684.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313759.1 → NP_001300688.1  mitogen-activated protein kinase 14B

    Status: VALIDATED

    Source sequence(s)
    BM037090, CR318593, EB900385, EH447521, EH457793
    UniProtKB/Swiss-Prot
    Q9DGE1
    UniProtKB/TrEMBL
    A0A8M1P824, F1RAA2
    Related
    ENSDARP00000040146.6, ENSDART00000040147.7
    Conserved Domains (2) summary
    smart00220
    Location:25 → 309
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:7 → 351
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    2710499..2760373
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017358195.2 → XP_017213684.1  mitogen-activated protein kinase 14B isoform X1

    UniProtKB/Swiss-Prot
    Q9DGE1
    UniProtKB/TrEMBL
    A0A8M6Z107, F1QQ40
    Related
    ENSDARP00000035686.6, ENSDART00000030921.8

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_178223.2: Suppressed sequence

    Description
    NM_178223.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DGE1.1 GenPept UniProtKB/Swiss-Prot:Q9DGE1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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