adra2c adrenoceptor alpha 2C [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: adra2cprovided by ZNC
Official Full Name: adrenoceptor alpha 2Cprovided by ZNC
Primary source: ZFIN:ZDB-GENE-021010-3
See related: Ensembl:ENSDARG00000069669 AllianceGenome:ZFIN:ZDB-GENE-021010-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:194523; zgc:194541
Summary: Enables alpha2-adrenergic receptor activity. Involved in adenylate cyclase-inhibiting adrenergic receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Is expressed in brain; eye; optic tectum; ovary; and torus lateralis. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human ADRA2C (adrenoceptor alpha 2C). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (40992919..40994217, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (40290132..40291430, complement)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables adrenergic receptor activity	IEA Inferred from Electronic Annotation more info
enables alpha2-adrenergic receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha2-adrenergic receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables alpha2-adrenergic receptor activity	IEA Inferred from Electronic Annotation more info
enables alpha2-adrenergic receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables epinephrine binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-inhibiting adrenergic receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within adrenergic receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within platelet activation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of smooth muscle contraction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of vasoconstriction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: alpha-2C adrenergic receptor

Names: adrenergic, alpha-2C-, receptor; alpha(2C)AR; alpha-2C adrenoceptor; alpha-2C adrenoreceptor; alpha-2CAR

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_207639.1 → NP_997522.1 alpha-2C adrenergic receptor

See identical proteins and their annotated locations for NP_997522.1

Status: PROVISIONAL

Source sequence(s)

AY048969

UniProtKB/Swiss-Prot

Q90WY6

UniProtKB/TrEMBL

B3DJZ9

Related

ENSDARP00000101388.2, ENSDART00000101562.5

Conserved Domains (3) summary

pfam00001
Location:52 → 409

7tm_1; 7 transmembrane receptor (rhodopsin family)

pfam08648
Location:224 → 301

DUF1777; Protein of unknown function (DUF1777)

cl21561
Location:44 → 233

7tm_4; Olfactory receptor