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adra2b adrenoceptor alpha 2B [ Danio rerio (zebrafish) ]

Gene ID: 266751, updated on 11-Apr-2024

Summary

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Official Symbol
adra2bprovided by ZNC
Official Full Name
adrenoceptor alpha 2Bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-021010-2
See related
Ensembl:ENSDARG00000102096 AllianceGenome:ZFIN:ZDB-GENE-021010-2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fb43d01; wu:fb43d01; zgc:194747
Summary
Enables alpha2-adrenergic receptor activity. Involved in adenylate cyclase-inhibiting adrenergic receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including digestive system; eye; heart; integument; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in diabetic neuropathy; hypertension; myocardial infarction; obesity; and type 2 diabetes mellitus. Orthologous to human ADRA2B (adrenoceptor alpha 2B). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See adra2b in Genome Data Viewer
Location:
chromosome: 8
Exon count:
1
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (40644871..40646400)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (40605306..40606835)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene izumo sperm-egg fusion 1 Neighboring gene dual specificity phosphatase 2 Neighboring gene uncharacterized LOC110440018 Neighboring gene glycerol-3-phosphate acyltransferase 2, mitochondrial

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression and function of alpha-adrenoceptors in zebrafish: drug effects, mRNA and receptor distributions. Ruuskanen JO, et al. J Neurochem, 2005 Sep. PMID 16000146
  2. Conserved structural, pharmacological and functional properties among the three human and five zebrafish alpha 2-adrenoceptors. Ruuskanen JO, et al. Br J Pharmacol, 2005 Jan. PMID 15655522, Free PMC Article
  3. Alpha-2 adrenoceptor subtypes: are more better? Bylund DB. Br J Pharmacol, 2005 Jan. PMID 15655520, Free PMC Article
  4. The regulatory role of the adrenergic agonists phenylephrine and isoproterenol on fetal hemoglobin expression and erythroid differentiation. Mei Y, et al. Endocrinology, 2013 Dec. PMID 24080366
  5. Fluoxetine modulates the transcription of genes involved in serotonin, dopamine and adrenergic signalling in zebrafish embryos. Cunha V, et al. Chemosphere, 2018 Jan. PMID 29145140

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables alpha-adrenergic receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables alpha2-adrenergic receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha2-adrenergic receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables epinephrine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenylate cyclase-inhibiting adrenergic receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within adrenergic receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
alpha-2B adrenergic receptor
Names
adrenergic, alpha-2B-, receptor
alpha(2B)AR
alpha-2B adrenoceptor
alpha-2B adrenoreceptor
alpha-2BAR

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207638.1 → NP_997521.1  alpha-2B adrenergic receptor

    See identical proteins and their annotated locations for NP_997521.1

    Status: PROVISIONAL

    Source sequence(s)
    AY048970
    UniProtKB/Swiss-Prot
    Q90WY5
    Related
    ENSDARP00000130082.1, ENSDART00000169311.2
    Conserved Domains (2) summary
    pfam00001
    Location:58 → 244
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:50 → 178
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    40644871..40646400
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q90WY5.1 GenPept UniProtKB/Swiss-Prot:Q90WY5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.