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pak2a p21 protein (Cdc42/Rac)-activated kinase 2a [ Danio rerio (zebrafish) ]

Gene ID: 266749, updated on 30-Mar-2024

Summary

Official Symbol
pak2aprovided by ZNC
Official Full Name
p21 protein (Cdc42/Rac)-activated kinase 2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-021011-2
See related
Ensembl:ENSDARG00000068177 AllianceGenome:ZFIN:ZDB-GENE-021011-2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
pak2; cb422; kinase; zgc:91798; wu:fb71h01; si:dz198m22.1
Summary
Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within blood vessel development. Predicted to be active in cytoplasm. Is expressed in several structures, including Kupffer's vesicle; axial mesoderm; axial vasculature; axis; and central nervous system. Human ortholog(s) of this gene implicated in ductal carcinoma in situ. Orthologous to human PAK2 (p21 (RAC1) activated kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

Location:
chromosome: 2
Exon count:
16
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (36608911..36636874)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (36626447..36654414)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101886113 Neighboring gene inhibitor of growth family, member 5b Neighboring gene kelch-like family member 6 Neighboring gene cyclin L1b

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within blood vessel development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase PAK 2; serine/threonine-protein kinase PAK 2a
Names
p21 (CDKN1A)-activated kinase 2
p21 (CDKN1A)-activated kinase 2a
p21-activated kinase 2
redhead
rhd
NP_001002717.1
XP_005171319.1
XP_005171320.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002717.1NP_001002717.1  serine/threonine-protein kinase PAK 2a

    See identical proteins and their annotated locations for NP_001002717.1

    Status: PROVISIONAL

    Source sequence(s)
    BC076511
    UniProtKB/TrEMBL
    A0A0R4IQG0, A0A8N7XJE5, B2GRT8, Q6DG42
    Related
    ENSDARP00000089188.2, ENSDART00000098417.3
    Conserved Domains (3) summary
    cd06655
    Location:222517
    STKc_PAK2; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 2
    smart00220
    Location:242493
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam00786
    Location:74129
    PBD; P21-Rho-binding domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    36608911..36636874
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005171262.4XP_005171319.1  serine/threonine-protein kinase PAK 2 isoform X1

    See identical proteins and their annotated locations for XP_005171319.1

    UniProtKB/TrEMBL
    A0A0R4IQG0, A0A8N7XJE5, B2GRT8, Q6DG42
    Related
    ENSDARP00000137659.2, ENSDART00000159541.2
    Conserved Domains (3) summary
    cd06655
    Location:222517
    STKc_PAK2; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 2
    smart00220
    Location:242493
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam00786
    Location:74129
    PBD; P21-Rho-binding domain
  2. XM_005171263.4XP_005171320.1  serine/threonine-protein kinase PAK 2 isoform X1

    See identical proteins and their annotated locations for XP_005171320.1

    UniProtKB/TrEMBL
    A0A0R4IQG0, A0A8N7XJE5, B2GRT8, Q6DG42
    Conserved Domains (3) summary
    cd06655
    Location:222517
    STKc_PAK2; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 2
    smart00220
    Location:242493
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam00786
    Location:74129
    PBD; P21-Rho-binding domain