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Adgrg2 adhesion G protein-coupled receptor G2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 266735, updated on 2-May-2024

Summary

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Official Symbol
Adgrg2provided by RGD
Official Full Name
adhesion G protein-coupled receptor G2provided by RGD
Primary source
RGD:628618
See related
Ensembl:ENSRNOG00000032472 AllianceGenome:RGD:628618
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
He6; Re6; Gpr64
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Located in apical plasma membrane. Human ortholog(s) of this gene implicated in X-linked congenital bilateral absence of vas deferens. Orthologous to human ADGRG2 (adhesion G protein-coupled receptor G2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 13.0), Heart (RPKM 11.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
Xq14
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (38106067..38231286, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (34297402..34422590, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (36930186..37054968, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene protein phosphatase with EF-hand domain 1 Neighboring gene metallothionein 1F Neighboring gene phosphorylase kinase regulatory subunit alpha 2 Neighboring gene 60S ribosomal protein L15 pseudogene Neighboring gene ribosomal protein S27a, pseudogene 5 Neighboring gene chaperonin containing TCP1 subunit 6A, pseudogene 17 Neighboring gene small integral membrane protein 30

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. HE6, a two-subunit heptahelical receptor associated with apical membranes of efferent and epididymal duct epithelia. Obermann H, et al. Mol Reprod Dev, 2003 Jan. PMID 12420295
  2. Quantitative proteomics identifies a Dab2/integrin module regulating cell migration. Teckchandani A, et al. J Cell Biol, 2009 Jul 13. PMID 19581412, Free PMC Article
  3. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Gonzalez-Begne M, et al. J Proteome Res, 2009 Mar. PMID 19199708, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
adhesion G-protein coupled receptor G2
Names
G-protein coupled receptor 64
epididymis-specific protein 6
re6 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270871.1 → NP_001257800.1  adhesion G-protein coupled receptor G2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001257800.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/TrEMBL
    A0A8L2QR31, A6IPL2
    Conserved Domains (2) summary
    cd15444
    Location:605 → 874
    7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:549 → 592
    GPS; GPCR proteolysis site, GPS, motif

  2. NM_001270872.1 → NP_001257801.1  adhesion G-protein coupled receptor G2 isoform 3

    See identical proteins and their annotated locations for NP_001257801.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/TrEMBL
    A0A8L2QR31, A6IPL1, A6IPL2
    Related
    ENSRNOP00000082277.1, ENSRNOT00000102123.1
    Conserved Domains (2) summary
    pfam01825
    Location:538 → 580
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:593 → 843
    7tm_4; Olfactory receptor

  3. NM_181366.2 → NP_852031.1  adhesion G-protein coupled receptor G2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_852031.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/Swiss-Prot
    Q8CJ06, Q8CJ07, Q8CJ11
    UniProtKB/TrEMBL
    A0A8L2QR31, A6IPL2, A6IPL3
    Related
    ENSRNOP00000039239.3, ENSRNOT00000040770.6
    Conserved Domains (2) summary
    pfam01825
    Location:566 → 608
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:621 → 871
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    38106067..38231286 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063279828.1 → XP_063135898.1  adhesion G-protein coupled receptor G2 isoform X4

    UniProtKB/TrEMBL
    A6IPL1

  2. XM_039099514.2 → XP_038955442.1  adhesion G-protein coupled receptor G2 isoform X2

    UniProtKB/TrEMBL
    A0A8L2QR31, A6IPL2
    Conserved Domains (2) summary
    cd15444
    Location:605 → 874
    7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:549 → 592
    GPS; GPCR proteolysis site, GPS, motif

  3. XM_039099517.2 → XP_038955445.1  adhesion G-protein coupled receptor G2 isoform X6

    UniProtKB/TrEMBL
    A0A8L2QR31, A6IPL2
    Conserved Domains (2) summary
    cd15444
    Location:580 → 849
    7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:524 → 567
    GPS; GPCR proteolysis site, GPS, motif

  4. XM_039099515.2 → XP_038955443.1  adhesion G-protein coupled receptor G2 isoform X3

    UniProtKB/TrEMBL
    A0A8L2QR31, A0A8L2QR66, A6IPL2
    Related
    ENSRNOP00000055623.3
    Conserved Domains (2) summary
    cd15444
    Location:594 → 863
    7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:538 → 581
    GPS; GPCR proteolysis site, GPS, motif

  5. XM_039099516.2 → XP_038955444.1  adhesion G-protein coupled receptor G2 isoform X5

    UniProtKB/TrEMBL
    A0A8L2QR31, A6IPL2
    Conserved Domains (2) summary
    cd15444
    Location:592 → 861
    7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:536 → 579
    GPS; GPCR proteolysis site, GPS, motif

  6. XM_039099518.2 → XP_038955446.1  adhesion G-protein coupled receptor G2 isoform X7

    UniProtKB/TrEMBL
    A0A8I5ZNY1
    Conserved Domains (2) summary
    cd15444
    Location:606 → 875
    7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:550 → 593
    GPS; GPCR proteolysis site, GPS, motif

  7. XM_039099513.2 → XP_038955441.1  adhesion G-protein coupled receptor G2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AP75, A0A8L2QR31, A6IPL2
    Related
    ENSRNOP00000096191.1
    Conserved Domains (2) summary
    cd15444
    Location:606 → 875
    7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:550 → 593
    GPS; GPCR proteolysis site, GPS, motif

  8. XM_063279827.1 → XP_063135897.1  adhesion G-protein coupled receptor G2 isoform X2

  9. XM_063279826.1 → XP_063135896.1  adhesion G-protein coupled receptor G2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AP75
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CJ11.1 GenPept UniProtKB/Swiss-Prot:Q8CJ11

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