Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cyp3a2provided by RGD
Official Full Name: cytochrome P450, family 3, subfamily a, polypeptide 2provided by RGD
Primary source: RGD:708379
See related: Ensembl:ENSRNOG00000032560 AllianceGenome:RGD:708379
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cyp3a11
Summary: Enables demethylase activity and testosterone 6-beta-hydroxylase activity. Involved in oxidative demethylation and xenobiotic metabolic process. Predicted to be located in cytoplasm. Used to study anxiety disorder. Biomarker of cholestasis and end stage renal disease. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; acute lymphoblastic leukemia; chronic myeloid leukemia; and essential hypertension. Orthologous to human CYP3A5 (cytochrome P450 family 3 subfamily A member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 8349.0) See more
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Genomic context

Location:: 12p11

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (14321771..14343886, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (9207978..9230064, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (11641500..11677818, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CYP3A deficiency alters bile acid homeostasis and leads to changes in hepatic susceptibility in rats.
Title: CYP3A deficiency alters bile acid homeostasis and leads to changes in hepatic susceptibility in rats.
Advanced oxidation protein products downregulate CYP1A2 and CYP3A4 expression and activity via the NF-kappaB-mediated signaling pathway in vitro and in vivo.
Title: Advanced oxidation protein products downregulate CYP1A2 and CYP3A4 expression and activity via the NF-κB-mediated signaling pathway in vitro and in vivo.
Schisandrin A significantly inhibited CYP3A activity in rat hepatic microsomes
Title: Inhibitory effects of continuous ingestion of Schisandrin A on CYP3A in the rat.
It shows the highest metabolic activities against enantiomers of carvedilol.
Title: Relative contribution of rat CYP isoforms responsible for stereoselective metabolism of carvedilol.
Pre-treatment with breviscapine injection also inhibited the mRNA expression of the hepatic CYP3A4.
Title: Impact of the Herbal Breviscapine on the Pharmacokinetics of Simvastatin in Rats: The Involvement of CYP3A4.
acute Formaldehyde (FA) poisoning suppressed the activities of CYP2C11, CYP2E1, and CYP3A2 and induced the activity of CYP1A2 in rats. And the change of CYP450 activity caused by acute FA poisoning may be associated with FA potential carcinogenic effects on the airways.
Title: The Effects of Formaldehyde on Cytochrome P450 Isoform Activity in Rats.
The PE extract also showed a significant potential to reduce CYP3A and CYP2C protein expression by approximately 50%.
Title: Effects of Paeonia emodi on hepatic cytochrome P450 (CYP3A2 and CYP2C11) expression and pharmacokinetics of carbamazepine in rats.
Data suggest that combined treatment with non-nutritive sweetener aspartame and insulin in a rat model of juvenile diabetes induces CYP2E1 in neurons of cerebrum and cerebellum without modifying CYP2E1 in liver, while CYP3A2 is induced in cerebrum/cerebellum and in liver.
Title: Aspartame Administration and Insulin Treatment Altered Brain Levels of CYP2E1 and CYP3A2 in Streptozotocin-Induced Diabetic Rats.
In blast-induced traumatic brain injury there was a significant impact on hepatic expression of CYP3A2.
Title: Impacts of Blast-Induced Traumatic Brain Injury on Expressions of Hepatic Cytochrome P450 1A2, 2B1, 2D1, and 3A2 in Rats.
hepatic expression of CYP4F2 and CYP3A2 genes in streptozotocin rats decreased
Title: α-Tocopherol status and altered expression of α-tocopherol-related proteins in streptozotocin-induced type 1 diabetes in rat models.

Submit: New GeneRIF Correction See all GeneRIFs (22)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables aromatase activity	IEA Inferred from Electronic Annotation more info
enables caffeine oxidase activity	ISO Inferred from Sequence Orthology more info
enables demethylase activity	IDA Inferred from Direct Assay more info	PubMed
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables estrogen 16-alpha-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables estrogen 2-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	ISO Inferred from Sequence Orthology more info
enables monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IEA Inferred from Electronic Annotation more info
enables retinoic acid 4-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables steroid binding	ISO Inferred from Sequence Orthology more info
enables steroid hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables testosterone 6-beta-hydroxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables testosterone 6-beta-hydroxylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables testosterone 6-beta-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables vitamin D 24-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables vitamin D3 25-hydroxylase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in alkaloid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in calcitriol biosynthetic process from calciol	IEA Inferred from Electronic Annotation more info
involved_in estrogen metabolic process	ISO Inferred from Sequence Orthology more info
involved_in lipid hydroxylation	ISO Inferred from Sequence Orthology more info
involved_in monoterpenoid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in oxidative demethylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in oxidative demethylation	IDA Inferred from Direct Assay more info	PubMed
involved_in oxidative demethylation	ISO Inferred from Sequence Orthology more info
involved_in retinoic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in retinol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in steroid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in steroid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in steroid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in vitamin D catabolic process	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic catabolic process	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in xenobiotic metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytochrome P450 3A2

Names: CYPIIIA2; P450-PCN2; P450/6-beta-A; cytochrome P450, family 3, subfamily a, polypeptide 11; cytochrome P450-PCN2; cytochrome P450/6-beta-A; testosterone 6-beta-hydroxylase

NP_695224.3

EC 1.14.14.1

XP_063127162.1

EC 1.14.14.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153312.3 → NP_695224.3 cytochrome P450 3A2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/Swiss-Prot

P05183, Q5FVU5, Q64629, Q64672

UniProtKB/TrEMBL

A0A8I6AL74, A6K1D7

Related

ENSRNOP00000068625.2, ENSRNOT00000087257.2

Conserved Domains (1) summary

cd20650
Location:67 → 493

CYP3A; cytochrome P450 family 3, subfamily A