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Ffar1 free fatty acid receptor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 266607, updated on 4-Jan-2025

Summary

Official Symbol
Ffar1provided by RGD
Official Full Name
free fatty acid receptor 1provided by RGD
Primary source
RGD:628613
See related
EnsemblRapid:ENSRNOG00000024009 AllianceGenome:RGD:628613
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gpr40
Summary
Enables fatty acid binding activity. Involved in G protein-coupled receptor signaling pathway; positive regulation of calcium ion transport into cytosol; and positive regulation of insulin secretion. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human FFAR1 (free fatty acid receptor 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See Ffar1 in Genome Data Viewer
Location:
1q21
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (95238785..95239689, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (86111368..86112272, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (89308475..89309379, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102554169 Neighboring gene free fatty acid receptor 3 Neighboring gene CD22 molecule Neighboring gene uncharacterized LOC108349549 Neighboring gene myelin-associated glycoprotein

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity  
enables bioactive lipid receptor activity  
enables bioactive lipid receptor activity  
enables bioactive lipid receptor activity  
enables bioactive lipid receptor activity  
enables fatty acid binding PubMed 
enables lipid binding  
Items 1 - 25 of 33
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway  
involved_in G protein-coupled receptor signaling pathway PubMed 
involved_in glucose homeostasis  
acts_upstream_of_or_within glucose homeostasis  
involved_in glucose homeostasis  
involved_in glucose homeostasis  
involved_in insulin secretion  
acts_upstream_of_or_within insulin secretion  
involved_in ion channel modulating, G protein-coupled receptor signaling pathway  
involved_in ion channel modulating, G protein-coupled receptor signaling pathway  
involved_in ligand-gated ion channel signaling pathway  
involved_in ligand-gated ion channel signaling pathway  
involved_in negative regulation of interleukin-1 beta production  
involved_in negative regulation of interleukin-1 beta production  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway  
involved_in positive regulation of calcium ion transport  
involved_in positive regulation of calcium ion transport  
involved_in positive regulation of calcium ion transport  
involved_in positive regulation of calcium ion transport into cytosol PubMed 
involved_in positive regulation of cytosolic calcium ion concentration  
involved_in positive regulation of cytosolic calcium ion concentration  
involved_in positive regulation of cytosolic calcium ion concentration  
involved_in positive regulation of cytosolic calcium ion concentration  
involved_in positive regulation of insulin secretion  
involved_in positive regulation of insulin secretion  
involved_in positive regulation of insulin secretion PubMed 
involved_in positive regulation of insulin secretion  
involved_in positive regulation of insulin secretion  
involved_in response to fatty acid  
involved_in response to fatty acid  
involved_in response to fatty acid  
involved_in response to fatty acid  
Items 1 - 25 of 33
Component Evidence Code Pubs
is_active_in plasma membrane  
located_in plasma membrane  
located_in plasma membrane  
located_in plasma membrane  

General protein information

Preferred Names
free fatty acid receptor 1
Names
G-protein coupled receptor 40

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153304.2 → NP_695216.1  free fatty acid receptor 1

    See identical proteins and their annotated locations for NP_695216.1

    Status: PROVISIONAL

    Source sequence(s)
    AF539810
    UniProtKB/Swiss-Prot
    Q8K3T4
    UniProtKB/TrEMBL
    F1LSV2
    Related
    ENSRNOP00000028533.1, ENSRNOT00000028533.5
    Conserved Domains (2) summary
    cd14964
    Location:7 → 33
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:6 → 289
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    95238785..95239689 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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