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Aldh1a3 aldehyde dehydrogenase 1 family, member A3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 266603, updated on 4-Jan-2025

Summary

Official Symbol
Aldh1a3provided by RGD
Official Full Name
aldehyde dehydrogenase 1 family, member A3provided by RGD
Primary source
RGD:628662
See related
EnsemblRapid:ENSRNOG00000052070 AllianceGenome:RGD:628662
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Aldh6
Summary
Enables aldehyde dehydrogenase [NAD(P)+] activity. Involved in several processes, including kidney development; pituitary gland development; and retinoic acid biosynthetic process. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in isolated microphthalmia 8. Orthologous to human ALDH1A3 (aldehyde dehydrogenase 1 family member A3). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Adrenal (RPKM 138.6), Lung (RPKM 99.7) and 8 other tissues See more
Orthologs
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Genomic context

See Aldh1a3 in Genome Data Viewer
Location:
1q22
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (129392516..129436552, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (119982272..120017416, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (127302920..127337828, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485129 Neighboring gene uncharacterized LOC102549616 Neighboring gene leucine-rich repeat kinase 1 Neighboring gene small nucleolar RNA SNORA40 Neighboring gene transfer RNA proline (anticodon AGG) 55 Neighboring gene uncharacterized LOC134485131

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables NAD+ binding  
enables NAD+ binding  
enables aldehyde dehydrogenase (NAD+) activity  
enables aldehyde dehydrogenase (NAD+) activity  
enables aldehyde dehydrogenase (NAD+) activity  
enables aldehyde dehydrogenase [NAD(P)+] activity PubMed 
enables aldehyde dehydrogenase [NAD(P)+] activity  
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor  
enables protein homodimerization activity  
enables protein homodimerization activity  
enables retinal dehydrogenase activity  
enables retinal dehydrogenase activity  
enables retinal dehydrogenase activity  
enables thyroid hormone binding  
enables thyroid hormone binding  
Items 1 - 25 of 44
Process Evidence Code Pubs
involved_in Harderian gland development  
involved_in Harderian gland development  
involved_in aldehyde metabolic process  
involved_in apoptotic process  
acts_upstream_of apoptotic process  
acts_upstream_of_or_within embryonic camera-type eye development  
involved_in embryonic camera-type eye development  
acts_upstream_of_or_within embryonic eye morphogenesis  
involved_in face development  
acts_upstream_of_or_within face development  
involved_in inner ear morphogenesis  
acts_upstream_of_or_within inner ear morphogenesis  
involved_in kidney development PubMed 
involved_in locomotory behavior  
acts_upstream_of_or_within locomotory behavior  
involved_in neuromuscular process controlling balance  
acts_upstream_of_or_within neuromuscular process controlling balance  
involved_in nose development  
involved_in nucleus accumbens development  
acts_upstream_of_or_within nucleus accumbens development  
involved_in olfactory pit development  
acts_upstream_of_or_within olfactory pit development  
involved_in optic cup morphogenesis involved in camera-type eye development  
acts_upstream_of_or_within optic cup morphogenesis involved in camera-type eye development  
involved_in pituitary gland development PubMed 
involved_in positive regulation of apoptotic process  
acts_upstream_of_or_within positive regulation of apoptotic process  
involved_in protein homotetramerization  
involved_in protein homotetramerization  
involved_in protein homotetramerization  
involved_in response to xenobiotic stimulus PubMed 
involved_in retinal metabolic process  
involved_in retinal metabolic process  
involved_in retinoic acid biosynthetic process  
involved_in retinoic acid biosynthetic process PubMed 
involved_in retinoic acid biosynthetic process PubMed 
acts_upstream_of_or_within retinoic acid biosynthetic process  
involved_in retinoic acid biosynthetic process  
involved_in retinoic acid biosynthetic process  
acts_upstream_of_or_within retinoic acid metabolic process  
involved_in retinoic acid metabolic process  
involved_in retinol metabolic process  
involved_in righting reflex  
acts_upstream_of_or_within righting reflex  
Items 1 - 25 of 44
Component Evidence Code Pubs
located_in cytoplasm  
located_in cytoplasm  

General protein information

Preferred Names
retinaldehyde dehydrogenase 3
Names
RALDH-3
aldehyde dehydrogenase 6
aldehyde dehydrogenase family 1 member A3
aldehyde dehydrogenase family 1, subfamily A3
ralDH3
NP_695212.2
XP_038958335.1
XP_038958341.1
XP_063138470.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153300.2NP_695212.2  retinaldehyde dehydrogenase 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A0G2JUS6, A0A9K3Y6M8, A9EEP5, B2GUU8
    Related
    ENSRNOP00000069212.2, ENSRNOT00000085158.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    129392516..129436552 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063282400.1XP_063138470.1  retinaldehyde dehydrogenase 3 isoform X2

  2. XM_039102407.2XP_038958335.1  retinaldehyde dehydrogenase 3 isoform X1

    UniProtKB/Swiss-Prot
    Q8K4D8
    UniProtKB/TrEMBL
    A0A8I6A4D2, A9EEP5
    Related
    ENSRNOP00000087440.1, ENSRNOT00000098068.2
    Conserved Domains (1) summary
    cd07141
    Location:33471
    ALDH_F1AB_F2_RALDH1; NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like
  3. XM_039102413.2XP_038958341.1  retinaldehyde dehydrogenase 3 isoform X2

    Conserved Domains (1) summary
    cl11961
    Location:1387
    ALDH-SF; NAD(P)+-dependent aldehyde dehydrogenase superfamily
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