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OR7A5 olfactory receptor family 7 subfamily A member 5 [ Homo sapiens (human) ]

Gene ID: 26659, updated on 5-Mar-2024

Summary

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Official Symbol
OR7A5provided by HGNC
Official Full Name
olfactory receptor family 7 subfamily A member 5provided by HGNC
Primary source
HGNC:HGNC:8368
See related
Ensembl:ENSG00000188269 AllianceGenome:HGNC:8368
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HTPCR2
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
all
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Genomic context

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Location:
19p13.12
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (14826241..14835185, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (14953804..14962748, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (14937053..14945997, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 333 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:14841378-14842577 Neighboring gene adhesion G protein-coupled receptor E2 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:14869525-14870048 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:14870049-14870574 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:14884311-14884812 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14179 Neighboring gene CRISPRi-validated cis-regulatory element chr19.2424 Neighboring gene TMEM167A pseudogene 2 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr19:14910875-14912074 Neighboring gene olfactory receptor family 7 subfamily C member 1 Neighboring gene olfactory receptor family 7 subfamily A member 10 Neighboring gene olfactory receptor family 7 subfamily A member 8 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Molecular cloning and chromosomal mapping of olfactory receptor genes expressed in the male germ line: evidence for their wide distribution in the human genome. Vanderhaeghen P, et al. Biochem Biophys Res Commun, 1997 Aug 18. PMID 9268701
  2. Expression of members of the putative olfactory receptor gene family in mammalian germ cells. Parmentier M, et al. Nature, 1992 Jan 30. PMID 1370859
  3. Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species. Vanderhaeghen P, et al. Genomics, 1997 Feb 1. PMID 9119360
  4. DEFOG: a practical scheme for deciphering families of genes. Fuchs T, et al. Genomics, 2002 Sep. PMID 12213199
  5. The DNA sequence and biology of human chromosome 19. Grimwood J, et al. Nature, 2004 Apr 1. PMID 15057824

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables olfactory receptor activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in detection of chemical stimulus involved in sensory perception of smell IEA
Inferred from Electronic Annotation
more info
  
involved_in sensory perception of smell NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
olfactory receptor 7A5
Names
olfactory receptor OR19-17
olfactory receptor TPCR92
olfactory receptor, family 7, subfamily A, member 5 pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370480.1 → NP_001357409.1  olfactory receptor 7A5

    Status: VALIDATED

    Source sequence(s)
    AC005255
    Consensus CDS
    CCDS12318.1
    UniProtKB/Swiss-Prot
    B2R682, Q15622, Q6IFP1, Q96R96
    UniProtKB/TrEMBL
    A0A126GW60
    Conserved Domains (1) summary
    cd15234
    Location:25 → 301
    7tmA_OR7-like; olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_001370481.1 → NP_001357410.1  olfactory receptor 7A5

    Status: VALIDATED

    Source sequence(s)
    AC005255
    Consensus CDS
    CCDS12318.1
    UniProtKB/Swiss-Prot
    B2R682, Q15622, Q6IFP1, Q96R96
    UniProtKB/TrEMBL
    A0A126GW60
    Conserved Domains (1) summary
    cd15234
    Location:25 → 301
    7tmA_OR7-like; olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. NM_001370482.1 → NP_001357411.1  olfactory receptor 7A5

    Status: VALIDATED

    Source sequence(s)
    AC005255
    Consensus CDS
    CCDS12318.1
    UniProtKB/Swiss-Prot
    B2R682, Q15622, Q6IFP1, Q96R96
    UniProtKB/TrEMBL
    A0A126GW60
    Conserved Domains (1) summary
    cd15234
    Location:25 → 301
    7tmA_OR7-like; olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

  4. NM_001370483.1 → NP_001357412.1  olfactory receptor 7A5

    Status: VALIDATED

    Source sequence(s)
    AC005255
    Consensus CDS
    CCDS12318.1
    UniProtKB/Swiss-Prot
    B2R682, Q15622, Q6IFP1, Q96R96
    UniProtKB/TrEMBL
    A0A126GW60
    Conserved Domains (1) summary
    cd15234
    Location:25 → 301
    7tmA_OR7-like; olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

  5. NM_017506.2 → NP_059976.1  olfactory receptor 7A5

    See identical proteins and their annotated locations for NP_059976.1

    Status: VALIDATED

    Source sequence(s)
    AC005255, AK312475, DA444957
    Consensus CDS
    CCDS12318.1
    UniProtKB/Swiss-Prot
    B2R682, Q15622, Q6IFP1, Q96R96
    UniProtKB/TrEMBL
    A0A126GW60
    Related
    ENSP00000316955.3, ENST00000322301.5
    Conserved Domains (1) summary
    cd15234
    Location:25 → 301
    7tmA_OR7-like; olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    14826241..14835185 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    14953804..14962748 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q15622.2 GenPept UniProtKB/Swiss-Prot:Q15622

Gene LinkOut

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