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Mmp23 matrix metallopeptidase 23 [ Mus musculus (house mouse) ]

Gene ID: 26561, updated on 5-Mar-2024

Summary

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Official Symbol
Mmp23provided by MGI
Official Full Name
matrix metallopeptidase 23provided by MGI
Primary source
MGI:MGI:1347361
See related
Ensembl:ENSMUSG00000029061 AllianceGenome:MGI:1347361
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CA-MMP
Summary
This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded protein contains an N-terminal cysteine array and a novel immunoglobulin-fold domain at the C-terminus. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing. [provided by RefSeq, Feb 2016]
Expression
Broad expression in ovary adult (RPKM 36.0), bladder adult (RPKM 24.1) and 17 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 E2; 4 86.85 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (155735111..155738982, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (155650655..155654539, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 35, member E2 Neighboring gene predicted gene 16023 Neighboring gene cyclin dependent kinase 11B Neighboring gene STARR-seq mESC enhancer starr_12269 Neighboring gene mindbomb E3 ubiquitin protein ligase 2 Neighboring gene STARR-seq mESC enhancer starr_12270 Neighboring gene STARR-seq mESC enhancer starr_12271 Neighboring gene STARR-positive B cell enhancer ABC_E6297 Neighboring gene fibronectin type III domain containing 10 Neighboring gene STARR-seq mESC enhancer starr_12272 Neighboring gene Ssu72 RNA polymerase II CTD phosphatase homolog (yeast) Neighboring gene predicted gene, 22573

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CA-MMP: a matrix metalloproteinase with a novel cysteine array, but without the classic cysteine switch. Pei D. FEBS Lett, 1999 Aug 27. PMID 10471791
  2. Matrix metalloproteinases in tumor invasion. Johansson N, et al. Cell Mol Life Sci, 2000 Jan 20. PMID 10949577
  3. Functional interactions between matrix metalloproteinases and glycosaminoglycans. Tocchi A, et al. FEBS J, 2013 May. PMID 23421805
  4. Matrix metalloproteinases 2 and 9 are dispensable for pancreatic islet formation and function in vivo. Perez SE, et al. Diabetes, 2005 Mar. PMID 15734845, Free PMC Article
  5. Foxl2 functions in sex determination and histogenesis throughout mouse ovary development. Garcia-Ortiz JE, et al. BMC Dev Biol, 2009 Jun 18. PMID 19538736, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC130334, MGC130335

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in collagen catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
matrix metalloproteinase-23
Names
CAMP metalloproteinase
cysteine array matrix metalloproteinase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320235.2 → NP_001307164.1  matrix metalloproteinase-23 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL627405
    UniProtKB/Swiss-Prot
    O88676
    Conserved Domains (4) summary
    smart00254
    Location:242 → 276
    ShKT; ShK toxin domain
    cd04278
    Location:88 → 241
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam00413
    Location:88 → 241
    Peptidase_M10; Matrixin
    cl11960
    Location:300 → 360
    Ig; Immunoglobulin domain

  2. NM_001424937.1 → NP_001411866.1  matrix metalloproteinase-23 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL627405

  3. NM_001424938.1 → NP_001411867.1  matrix metalloproteinase-23 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL627405

  4. NM_011985.4 → NP_036115.1  matrix metalloproteinase-23 isoform 1 precursor

    See identical proteins and their annotated locations for NP_036115.1

    Status: REVIEWED

    Source sequence(s)
    AL627405
    Consensus CDS
    CCDS19034.1
    UniProtKB/Swiss-Prot
    O88676, Q3KNC0
    Related
    ENSMUSP00000030937.2, ENSMUST00000030937.2
    Conserved Domains (3) summary
    smart00254
    Location:256 → 290
    ShKT; ShK toxin domain
    cd04278
    Location:88 → 255
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    cl11960
    Location:314 → 374
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    155735111..155738982 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538882.4 → XP_006538945.1  matrix metalloproteinase-23 isoform X3

    See identical proteins and their annotated locations for XP_006538945.1

    UniProtKB/Swiss-Prot
    O88676, Q3KNC0
    Conserved Domains (3) summary
    smart00254
    Location:256 → 290
    ShKT; ShK toxin domain
    cd04278
    Location:88 → 255
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    cl11960
    Location:314 → 374
    Ig; Immunoglobulin domain

  2. XM_006538881.4 → XP_006538944.1  matrix metalloproteinase-23 isoform X2

    Conserved Domains (3) summary
    smart00254
    Location:271 → 305
    ShKT; ShK toxin domain
    cd04278
    Location:88 → 270
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    cl11960
    Location:329 → 389
    Ig; Immunoglobulin domain

  3. XM_006538880.5 → XP_006538943.1  matrix metalloproteinase-23 isoform X1

    See identical proteins and their annotated locations for XP_006538943.1

    Conserved Domains (3) summary
    smart00254
    Location:285 → 319
    ShKT; ShK toxin domain
    cd04278
    Location:88 → 284
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    cl11960
    Location:343 → 403
    Ig; Immunoglobulin domain

  4. XM_006538879.4 → XP_006538942.1  matrix metalloproteinase-23 isoform X1

    See identical proteins and their annotated locations for XP_006538942.1

    Conserved Domains (3) summary
    smart00254
    Location:285 → 319
    ShKT; ShK toxin domain
    cd04278
    Location:88 → 284
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    cl11960
    Location:343 → 403
    Ig; Immunoglobulin domain

  5. XM_036164136.1 → XP_036020029.1  matrix metalloproteinase-23 isoform X3

    UniProtKB/Swiss-Prot
    O88676, Q3KNC0
    Conserved Domains (3) summary
    smart00254
    Location:256 → 290
    ShKT; ShK toxin domain
    cd04278
    Location:88 → 255
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    cl11960
    Location:314 → 374
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88676.1 GenPept UniProtKB/Swiss-Prot:O88676

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