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PTPN18 protein tyrosine phosphatase non-receptor type 18 [ Homo sapiens (human) ]

Gene ID: 26469, updated on 11-Apr-2024

Summary

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Official Symbol
PTPN18provided by HGNC
Official Full Name
protein tyrosine phosphatase non-receptor type 18provided by HGNC
Primary source
HGNC:HGNC:9649
See related
Ensembl:ENSG00000072135 MIM:606587; AllianceGenome:HGNC:9649
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BDP1; PTP-HSCF
Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, the mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This protein can differentially dephosphorylate autophosphorylated tyrosine kinases that are overexpressed in tumor tissues, and it appears to regulate HER2, a member of the epidermal growth factor receptor family of receptor tyrosine kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]
Expression
Ubiquitous expression in lymph node (RPKM 34.1), spleen (RPKM 27.5) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
2q21.1
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (130356056..130375405)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (130789979..130809308)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (131113629..131132978)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16526 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16527 Neighboring gene coiled-coil domain containing 115 Neighboring gene IMP U3 small nucleolar ribonucleoprotein 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11956 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11957 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:131129403-131130030 Neighboring gene uncharacterized LOC105373618 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16528 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11959 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11960 Neighboring gene fatty acyl-CoA reductase 2 pseudogene 2 Neighboring gene Kruppel like factor 2 pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. PTPN18 Serves as a Potential Oncogene for Glioblastoma by Enhancing Immune Suppression. Wang T, et al. Oxid Med Cell Longev, 2023. PMID 36846716, Free PMC Article
  2. Phospho-PTM proteomic discovery of novel EPO- modulated kinases and phosphatases, including PTPN18 as a positive regulator of EPOR/JAK2 Signaling. Held MA, et al. Cell Signal, 2020 May. PMID 32027948, Free PMC Article
  3. Downregulation of PTPN18 can inhibit proliferation and metastasis and promote apoptosis of endometrial cancer. Cai J, et al. Clin Exp Pharmacol Physiol, 2019 Aug. PMID 31034093
  4. A bioinformatics analysis of protein tyrosine phosphatases in humans. Gandhi TK, et al. DNA Res, 2005. PMID 16303740
  5. Characterization of the PEST family protein tyrosine phosphatase BDP1. Kim YW, et al. Oncogene, 1996 Nov 21. PMID 8950995

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PTPN18 Serves as a Potential Oncogene for Glioblastoma by Enhancing Immune Suppression.
    Title: PTPN18 Serves as a Potential Oncogene for Glioblastoma by Enhancing Immune Suppression.
  2. Phospho-PTM proteomic discovery of novel EPO- modulated kinases and phosphatases, including PTPN18 as a positive regulator of EPOR/JAK2 Signaling.
    Title: Phospho-PTM proteomic discovery of novel EPO- modulated kinases and phosphatases, including PTPN18 as a positive regulator of EPOR/JAK2 Signaling.
  3. Downregulation of PTPN18 can inhibit proliferation and metastasis and promote apoptosis of endometrial cancer
    Title: Downregulation of PTPN18 can inhibit proliferation and metastasis and promote apoptosis of endometrial cancer.
  4. PTPN12, PTPRN and PTPN18 were independent prognostic factors in Hepatocellular Carcinoma.
    Title: Prognostic Value of Phosphotyrosine Phosphatases in Hepatocellular Carcinoma.
  5. PTPN18 regulates HER2-mediated cellular functions through defining both its phosphorylation and ubiquitination barcodes.
    Title: The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes.
  6. novel isoform of PTPN18 based on analysis of expressed sequence tags was discovered; deletion of 4 exons in the catalytic domain of the isoform may alter enzymatic activity; 2 of the novel isoform predictions were experimentally validated through RT-PCR
    Title: A bioinformatics analysis of protein tyrosine phosphatases in humans.
  7. BDP1 has a role in negative regulation of HER2 signaling
    Title: Negative regulation of HER2 signaling by the PEST-type protein-tyrosine phosphatase BDP1.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables non-membrane spanning protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine phosphatase activity EXP
Inferred from Experiment
more info
 PubMed 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in blastocyst formation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of ERBB signaling pathway TAS
Traceable Author Statement
more info
  
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein dephosphorylation TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tyrosine-protein phosphatase non-receptor type 18
Names
brain-derived phosphatase
protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
NP_001135842.1
NP_055184.2
XP_006712479.1
XP_006712480.1
XP_047299865.1
XP_047299866.1
XP_054197334.1
XP_054197335.1
XP_054197336.1
XP_054197337.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142370.2 → NP_001135842.1  tyrosine-protein phosphatase non-receptor type 18 isoform 2

    See identical proteins and their annotated locations for NP_001135842.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks four internal exons in the 5' coding region that results in the loss of an in-frame segment, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC132479, AK303804, BM789073, CA310199, DN995571
    Consensus CDS
    CCDS46410.1
    UniProtKB/TrEMBL
    Q7Z637
    Related
    ENSP00000310092.5, ENST00000347849.7
    Conserved Domains (2) summary
    cd00047
    Location:32 → 183
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    pfam00102
    Location:32 → 183
    Y_phosphatase; Protein-tyrosine phosphatase

  2. NM_014369.4 → NP_055184.2  tyrosine-protein phosphatase non-receptor type 18 isoform 1

    See identical proteins and their annotated locations for NP_055184.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC132479, AK303804, BM789073, CA310199, DN995571, X79568
    Consensus CDS
    CCDS2161.1
    UniProtKB/Swiss-Prot
    B4E1E6, Q53P42, Q99952
    Related
    ENSP00000175756.5, ENST00000175756.10
    Conserved Domains (2) summary
    cd00047
    Location:59 → 290
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    pfam00102
    Location:56 → 290
    Y_phosphatase; Protein-tyrosine phosphatase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    130356056..130375405
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006712417.2 → XP_006712480.1  tyrosine-protein phosphatase non-receptor type 18 isoform X1

    See identical proteins and their annotated locations for XP_006712480.1

    Conserved Domains (2) summary
    cd00047
    Location:59 → 290
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    pfam00102
    Location:56 → 290
    Y_phosphatase; Protein-tyrosine phosphatase

  2. XM_006712416.5 → XP_006712479.1  tyrosine-protein phosphatase non-receptor type 18 isoform X2

    UniProtKB/TrEMBL
    Q7Z637
    Conserved Domains (2) summary
    cd00047
    Location:32 → 183
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    pfam00102
    Location:32 → 183
    Y_phosphatase; Protein-tyrosine phosphatase

  3. XM_047443910.1 → XP_047299866.1  tyrosine-protein phosphatase non-receptor type 18 isoform X4

  4. XM_047443909.1 → XP_047299865.1  tyrosine-protein phosphatase non-receptor type 18 isoform X3

    Related
    ENSP00000387031.2, ENST00000409022.2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    130789979..130809308
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054341359.1 → XP_054197334.1  tyrosine-protein phosphatase non-receptor type 18 isoform X1

  2. XM_054341360.1 → XP_054197335.1  tyrosine-protein phosphatase non-receptor type 18 isoform X2

  3. XM_054341362.1 → XP_054197337.1  tyrosine-protein phosphatase non-receptor type 18 isoform X4

  4. XM_054341361.1 → XP_054197336.1  tyrosine-protein phosphatase non-receptor type 18 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99952.2 GenPept UniProtKB/Swiss-Prot:Q99952

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