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Slc27a2 solute carrier family 27 (fatty acid transporter), member 2 [ Mus musculus (house mouse) ]

Gene ID: 26458, updated on 4-Jan-2025

Summary

Official Symbol
Slc27a2provided by MGI
Official Full Name
solute carrier family 27 (fatty acid transporter), member 2provided by MGI
Primary source
MGI:MGI:1347099
See related
Ensembl:ENSMUSG00000027359 AllianceGenome:MGI:1347099
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
VLCS; Vlac; FATP2; Vlacs; ACSVL1
Summary
Enables long-chain fatty acid transmembrane transporter activity; long-chain fatty acid-CoA ligase activity; and very long-chain fatty acid-CoA ligase activity. Acts upstream of or within fatty acid transport; long-chain fatty acid metabolic process; and very long-chain fatty acid catabolic process. Located in endoplasmic reticulum; peroxisome; and plasma membrane. Is expressed in several structures, including brain; genitourinary system; liver; lung; and sensory organ. Orthologous to human SLC27A2 (solute carrier family 27 member 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in kidney adult (RPKM 780.2), liver adult (RPKM 522.9) and 3 other tissues See more
Orthologs
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Genomic context

See Slc27a2 in Genome Data Viewer
Location:
2 F1; 2 61.76 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (126394944..126430163)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (126553024..126588243)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ATPase, class I, type 8B, member 4 Neighboring gene Brca1 associated protein 1 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:126292531-126292684 Neighboring gene STARR-positive B cell enhancer ABC_E4495 Neighboring gene STARR-seq mESC enhancer starr_05604 Neighboring gene STARR-seq mESC enhancer starr_05605 Neighboring gene predicted gene, 26697 Neighboring gene STARR-seq mESC enhancer starr_05606 Neighboring gene STARR-positive B cell enhancer ABC_E11157 Neighboring gene histidine decarboxylase Neighboring gene GA repeat binding protein, beta 1 Neighboring gene zinc finger, BED domain containing 4 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding  
enables arachidonate-CoA ligase activity  
enables cholate-CoA ligase activity  
enables enzyme binding  
enables enzyme binding  
enables fatty acid transmembrane transporter activity PubMed 
enables long-chain fatty acid transmembrane transporter activity  
enables long-chain fatty acid transmembrane transporter activity PubMed 
enables long-chain fatty acid transmembrane transporter activity PubMed 
enables long-chain fatty acid transmembrane transporter activity  
enables long-chain fatty acid-CoA ligase activity  
enables long-chain fatty acid-CoA ligase activity PubMed 
enables long-chain fatty acid-CoA ligase activity PubMed 
enables long-chain fatty acid-CoA ligase activity  
enables long-chain fatty acid-CoA ligase activity PubMed 
enables oleate transmembrane transporter activity  
enables phytanate-CoA ligase activity  
enables phytanate-CoA ligase activity  
enables pristanate-CoA ligase activity  
enables pristanate-CoA ligase activity  
enables very long-chain fatty acid-CoA ligase activity PubMed 
enables very long-chain fatty acid-CoA ligase activity PubMed 
enables very long-chain fatty acid-CoA ligase activity  
Process Evidence Code Pubs
involved_in bile acid biosynthetic process  
involved_in bile acid biosynthetic process  
involved_in bile acid metabolic process  
involved_in fatty acid alpha-oxidation  
involved_in fatty acid alpha-oxidation  
involved_in fatty acid beta-oxidation  
involved_in fatty acid beta-oxidation  
acts_upstream_of_or_within fatty acid transport PubMed 
involved_in long-chain fatty acid import into cell  
involved_in long-chain fatty acid import into cell  
acts_upstream_of long-chain fatty acid import into cell  
involved_in long-chain fatty acid metabolic process  
acts_upstream_of_or_within long-chain fatty acid metabolic process PubMed 
involved_in long-chain fatty acid metabolic process  
acts_upstream_of_or_within long-chain fatty acid metabolic process PubMed 
involved_in methyl-branched fatty acid metabolic process  
involved_in methyl-branched fatty acid metabolic process  
acts_upstream_of_or_within very long-chain fatty acid catabolic process PubMed 
acts_upstream_of_or_within very long-chain fatty acid metabolic process PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum PubMed 
located_in endoplasmic reticulum  
located_in endoplasmic reticulum PubMed 
located_in endoplasmic reticulum lumen  
located_in endoplasmic reticulum lumen PubMed 
is_active_in endoplasmic reticulum membrane  
located_in endoplasmic reticulum membrane  
located_in endoplasmic reticulum membrane  
located_in mitochondrion PubMed 
is_active_in peroxisomal membrane  
located_in peroxisomal membrane  
located_in peroxisomal membrane PubMed 
located_in peroxisome PubMed 
located_in peroxisome PubMed 
located_in peroxisome  
located_in peroxisome PubMed 
is_active_in plasma membrane  
located_in plasma membrane PubMed 

General protein information

Preferred Names
long-chain fatty acid transport protein 2
Names
FATP-2
THCA-CoA ligase
arachidonate--CoA ligase
fatty acid transport protein 2
fatty-acid-coenzyme A ligase, very long-chain 1
long-chain-fatty-acid--CoA ligase
phytanate--CoA ligase
solute carrier family 27 member 2
very long-chain acyl-CoA synthetase
very long-chain acyl-Coenzyme A dehydrogenase synthase
very long-chain-fatty-acid-CoA ligase
NP_036108.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011978.2NP_036108.2  long-chain fatty acid transport protein 2

    See identical proteins and their annotated locations for NP_036108.2

    Status: VALIDATED

    Source sequence(s)
    AF033031, AI326155, AK165446
    Consensus CDS
    CCDS16683.1
    UniProtKB/Swiss-Prot
    O35488, O70550, O88560, Q91WV6
    UniProtKB/TrEMBL
    Q3UNR3
    Related
    ENSMUSP00000057595.8, ENSMUST00000061491.14
    Conserved Domains (1) summary
    cd05938
    Location:74610
    hsFATP2a_ACSVL_like; Fatty acid transport proteins (FATP) including hsFATP2, hsFATP5, and hsFATP6, and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    126394944..126430163
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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