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Rpl27a ribosomal protein L27A [ Mus musculus (house mouse) ]

Gene ID: 26451, updated on 5-Mar-2024

Summary

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Official Symbol
Rpl27aprovided by MGI
Official Full Name
ribosomal protein L27Aprovided by MGI
Primary source
MGI:MGI:1347076
See related
Ensembl:ENSMUSG00000046364 AllianceGenome:MGI:1347076
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
L29; L27'; L27A
Summary
A structural constituent of ribosome. Acts upstream of or within translation. Located in cytosolic ribosome. Is expressed in endolymphatic appendage and head. Orthologous to human RPL27A (ribosomal protein L27a). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 331.7), liver E14.5 (RPKM 304.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Rpl27a in Genome Data Viewer
Location:
7 E3; 7 57.26 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (109118354..109121967)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (109519195..109522369)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 33 Neighboring gene RIKEN cDNA 1700095J03 gene Neighboring gene tripartite motif-containing 66 Neighboring gene STARR-seq mESC enhancer starr_19797 Neighboring gene predicted gene, 24888 Neighboring gene DENN domain containing 2B Neighboring gene small nucleolar RNA, H/ACA box 3 Neighboring gene STARR-seq mESC enhancer starr_19802 Neighboring gene STARR-seq mESC enhancer starr_19804 Neighboring gene STARR-positive B cell enhancer ABC_E4965 Neighboring gene VISTA enhancer mm1407 Neighboring gene cDNA sequence BC051019 Neighboring gene A kinase interacting protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genomic structure and chromosome location of RPL27A/Rpl27a, the genes encoding human and mouse ribosomal protein L27A. Kusuda J, et al. Cytogenet Cell Genet, 1999. PMID 10449908
  2. Functional substitution of mouse ribosomal protein L27' for yeast ribosomal protein L29 in yeast ribosomes. Fleming G, et al. Proc Natl Acad Sci U S A, 1989 Jan. PMID 2643099, Free PMC Article
  3. Isolation and characterisation of a murine cDNA clone highly homologous to the yeast L29 ribosomal protein gene. Belhumeur P, et al. Nucleic Acids Res, 1987 Feb 11. PMID 2434927, Free PMC Article
  4. Rpl27a mutation in the sooty foot ataxia mouse phenocopies high p53 mouse models. Terzian T, et al. J Pathol, 2011 Aug. PMID 21674502, Free PMC Article
  5. Impaired skin wound healing in peroxisome proliferator-activated receptor (PPAR)alpha and PPARbeta mutant mice. Michalik L, et al. J Cell Biol, 2001 Aug 20. PMID 11514592, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC66730, MGC107695

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables structural constituent of ribosome ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within translation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in translation at postsynapse NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in translation at presynapse NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic large ribosomal subunit IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of cytosolic large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
located_in cytosolic ribosome IGI
Inferred from Genetic Interaction
more info
 PubMed 
located_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
part_of large ribosomal subunit IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynapse NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in presynapse NAS
Non-traceable Author Statement
more info
 PubMed 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in ribosome NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
large ribosomal subunit protein uL15
Names
60S ribosomal protein L27a
ribosomal protein L29 homolog
NP_036105.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011975.4 → NP_036105.2  large ribosomal subunit protein uL15

    See identical proteins and their annotated locations for NP_036105.2

    Status: VALIDATED

    Source sequence(s)
    AC124457
    Consensus CDS
    CCDS40083.1
    UniProtKB/Swiss-Prot
    P14115, Q9CQ16, Q9R1X6
    Related
    ENSMUSP00000123410.2, ENSMUST00000143107.2
    Conserved Domains (1) summary
    PTZ00160
    Location:1 → 148
    PTZ00160; 60S ribosomal protein L27a; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    109118354..109121967
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P14115.5 GenPept UniProtKB/Swiss-Prot:P14115

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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