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Git2 GIT ArfGAP 2 [ Mus musculus (house mouse) ]

Gene ID: 26431, updated on 11-Apr-2024

Summary

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Official Symbol
Git2provided by MGI
Official Full Name
GIT ArfGAP 2provided by MGI
Primary source
MGI:MGI:1347053
See related
Ensembl:ENSMUSG00000041890 AllianceGenome:MGI:1347053
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CAT2; mKIAA0148; 1500036H07Rik; 5830420E16Rik; 6430510B20Rik; 9630056M03Rik; B230104M05Rik
Summary
Predicted to enable GTPase activator activity and metal ion binding activity. Involved in presynaptic modulation of chemical synaptic transmission and regulation of synaptic vesicle exocytosis. Acts upstream of or within behavioral response to pain. Is active in calyx of Held. Is expressed in genitourinary system. Orthologous to human GIT2 (GIT ArfGAP 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 38.4), lung adult (RPKM 24.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 F; 5 55.99 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (114865469..114912647, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (114727408..114774588, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34931 Neighboring gene STARR-positive B cell enhancer ABC_E10341 Neighboring gene trichoplein, keratin filament binding Neighboring gene microRNA 7028 Neighboring gene RIKEN cDNA 4930515G01 gene Neighboring gene STARR-positive B cell enhancer ABC_E3602 Neighboring gene ankyrin repeat domain 13a Neighboring gene STARR-positive B cell enhancer ABC_E3603 Neighboring gene STARR-seq mESC enhancer starr_14089 Neighboring gene RIKEN cDNA 1500011B03 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Multidimensional informatic deconvolution defines gender-specific roles of hypothalamic GIT2 in aging trajectories. van Gastel J, et al. Mech Ageing Dev, 2019 Dec. PMID 31574270
  2. Genomic deletion of GIT2 induces a premature age-related thymic dysfunction and systemic immune system disruption. Siddiqui S, et al. Aging (Albany NY), 2017 Mar 4. PMID 28260693, Free PMC Article
  3. GIT2 Acts as a Systems-Level Coordinator of Neurometabolic Activity and Pathophysiological Aging. Martin B, et al. Front Endocrinol (Lausanne), 2015. PMID 26834700, Free PMC Article
  4. GIT2 deficiency attenuates concanavalin A-induced hepatitis in mice. Hao YE, et al. FEBS Open Bio, 2015. PMID 26380813, Free PMC Article
  5. The cytoskeletal regulatory scaffold protein GIT2 modulates mesenchymal stem cell differentiation and osteoblastogenesis. Wang X, et al. Biochem Biophys Res Commun, 2012 Aug 24. PMID 22846567, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Regulation of microtubule nucleation in mouse bone marrow-derived mast cells by ARF GTPase-activating protein GIT2.
    Title: Regulation of microtubule nucleation in mouse bone marrow-derived mast cells by ARF GTPase-activating protein GIT2.
  2. A similar number of both total and gender-unique transcripts were significantly altered in response to GIT2 heterozygosity in early life-stage (2 month-old) mice
    Title: Multidimensional informatic deconvolution defines gender-specific roles of hypothalamic GIT2 in aging trajectories.
  3. GIT2(-/-) mice present a prematurely distorted thymic structure and dysfunction compared to age-matched 12 month-old wild-type control (C57BL/6) mice.
    Title: Genomic deletion of GIT2 induces a premature age-related thymic dysfunction and systemic immune system disruption.
  4. GIT2 plays an important role in MRE11/ATM/H2AX-mediated DNA damage responses.
    Title: Nuclear GIT2 is an ATM substrate and promotes DNA repair.
  5. GIT2 is an essential terminator of TLR signaling and loss of GIT2 leads to uncontrolled inflammation and severe organ damage
    Title: The GTPase-activating protein GIT2 protects against colitis by negatively regulating Toll-like receptor signaling.
  6. these findings underscore the importance of the cytoskeleton in both osteoblast and osteoclast function and demonstrate that GIT2 plays essential roles in skeletal metabolism, affecting both bone formation and bone resorption in vivo.
    Title: The cytoskeletal regulatory scaffold protein GIT2 modulates mesenchymal stem cell differentiation and osteoblastogenesis.
  7. GIT2 has a key role in regulating the chemokine-mediated motility of double-positive thymocytes
    Title: Regulation of thymocyte positive selection and motility by GIT2.
  8. Results suggest that paxillin-kinase-linker is an integral component of growth factor and cell adhesion cross-talk signaling, controlling the development of front-rear cell polarity and directional cell migration.
    Title: Paxillin-kinase-linker tyrosine phosphorylation regulates directional cell migration.
  9. Hence, GIT2-KO mice display anxiety-like behavior in an absence of depressive-like responses.
    Title: Anxiety-like behaviors in mice lacking GIT2.
  10. Analysis of endogenous GIT expression revealed a nearly ubiquitous distribution of GIT2, whereas GIT1 is restricted to specific cell types even in tissues with apparently high GIT1 expression and is entirely absent from some tissues.
    Title: Differential expression of the ARF GAP genes GIT1 and GIT2 in mouse tissues.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0148

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within behavioral response to pain IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in brain development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in presynaptic modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in presynaptic modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of ARF protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of synaptic vesicle exocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of synaptic vesicle exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle recycling IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in calyx of Held IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in calyx of Held IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ARF GTPase-activating protein GIT2
Names
ARF GAP GIT2
ARF GTPase activating protein 2
G protein-coupled receptor kinase-interactor 2
GRK-interacting protein 2
cool-interacting tyrosine-phosphorylated protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077359.2 → NP_001070827.1  ARF GTPase-activating protein GIT2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC087330
    UniProtKB/TrEMBL
    J3QK07
    Conserved Domains (6) summary
    smart00105
    Location:2 → 124
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    cd00204
    Location:109 → 220
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam08518
    Location:267 → 295
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:559 → 673
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]

  2. NM_001077360.2 → NP_001070828.1  ARF GTPase-activating protein GIT2 isoform 3

    See identical proteins and their annotated locations for NP_001070828.1

    Status: VALIDATED

    Source sequence(s)
    AC087330
    Consensus CDS
    CCDS39223.1
    UniProtKB/TrEMBL
    J3QK07, Q6PGJ1, Q80XR8
    Related
    ENSMUSP00000039718.8, ENSMUST00000043283.14
    Conserved Domains (6) summary
    smart00105
    Location:2 → 124
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    cd00204
    Location:109 → 220
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam08518
    Location:266 → 294
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:558 → 672
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]

  3. NM_001347400.2 → NP_001334329.1  ARF GTPase-activating protein GIT2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC087330
    Consensus CDS
    CCDS84939.1
    UniProtKB/TrEMBL
    E9PVA6, J3QK07
    Related
    ENSMUSP00000083754.5, ENSMUST00000086564.11

  4. NM_001429058.1 → NP_001415987.1  ARF GTPase-activating protein GIT2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC087330

  5. NM_001429059.1 → NP_001415988.1  ARF GTPase-activating protein GIT2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC087330

  6. NM_001429060.1 → NP_001415989.1  ARF GTPase-activating protein GIT2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC087330

  7. NM_001429061.1 → NP_001415990.1  ARF GTPase-activating protein GIT2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC087330

  8. NM_001429062.1 → NP_001415991.1  ARF GTPase-activating protein GIT2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC087330

  9. NM_001429063.1 → NP_001415992.1  ARF GTPase-activating protein GIT2 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC087330

  10. NM_001429064.1 → NP_001415993.1  ARF GTPase-activating protein GIT2 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC087330

  11. NM_001429065.1 → NP_001415994.1  ARF GTPase-activating protein GIT2 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC087330

  12. NM_001429066.1 → NP_001415995.1  ARF GTPase-activating protein GIT2 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC087330

  13. NM_001429067.1 → NP_001415996.1  ARF GTPase-activating protein GIT2 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC087330

  14. NM_001429068.1 → NP_001415997.1  ARF GTPase-activating protein GIT2 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC087330

  15. NM_001429069.1 → NP_001415998.1  ARF GTPase-activating protein GIT2 isoform 16

    Status: VALIDATED

    Source sequence(s)
    AC087330

  16. NM_001429070.1 → NP_001415999.1  ARF GTPase-activating protein GIT2 isoform 17

    Status: VALIDATED

    Source sequence(s)
    AC087330

  17. NM_001429071.1 → NP_001416000.1  ARF GTPase-activating protein GIT2 isoform 18

    Status: VALIDATED

    Source sequence(s)
    AC087330

  18. NM_001429072.1 → NP_001416001.1  ARF GTPase-activating protein GIT2 isoform 19

    Status: VALIDATED

    Source sequence(s)
    AC087330

  19. NM_001429073.1 → NP_001416002.1  ARF GTPase-activating protein GIT2 isoform 20

    Status: VALIDATED

    Source sequence(s)
    AC087330

  20. NM_001429074.1 → NP_001416003.1  ARF GTPase-activating protein GIT2 isoform 21

    Status: VALIDATED

    Source sequence(s)
    AC087330

  21. NM_001429075.1 → NP_001416004.1  ARF GTPase-activating protein GIT2 isoform 22

    Status: VALIDATED

    Source sequence(s)
    AC087330

  22. NM_001429076.1 → NP_001416005.1  ARF GTPase-activating protein GIT2 isoform 23

    Status: VALIDATED

    Source sequence(s)
    AC087330

  23. NM_001429077.1 → NP_001416006.1  ARF GTPase-activating protein GIT2 isoform 24

    Status: VALIDATED

    Source sequence(s)
    AC087330

  24. NM_001429078.1 → NP_001416007.1  ARF GTPase-activating protein GIT2 isoform 25

    Status: VALIDATED

    Source sequence(s)
    AC087330

  25. NM_001429079.1 → NP_001416008.1  ARF GTPase-activating protein GIT2 isoform 26

    Status: VALIDATED

    Source sequence(s)
    AC087330

  26. NM_001429080.1 → NP_001416009.1  ARF GTPase-activating protein GIT2 isoform 27

    Status: VALIDATED

    Source sequence(s)
    AC087330

  27. NM_001429081.1 → NP_001416010.1  ARF GTPase-activating protein GIT2 isoform 28

    Status: VALIDATED

    Source sequence(s)
    AC087330

  28. NM_001429082.1 → NP_001416011.1  ARF GTPase-activating protein GIT2 isoform 29

    Status: VALIDATED

    Source sequence(s)
    AC087330

  29. NM_001429083.1 → NP_001416012.1  ARF GTPase-activating protein GIT2 isoform 30

    Status: VALIDATED

    Source sequence(s)
    AC087330

  30. NM_001429084.1 → NP_001416013.1  ARF GTPase-activating protein GIT2 isoform 31

    Status: VALIDATED

    Source sequence(s)
    AC087330

  31. NM_001429085.1 → NP_001416014.1  ARF GTPase-activating protein GIT2 isoform 32

    Status: VALIDATED

    Source sequence(s)
    AC087330

  32. NM_001429086.1 → NP_001416015.1  ARF GTPase-activating protein GIT2 isoform 33

    Status: VALIDATED

    Source sequence(s)
    AC087330

  33. NM_001429087.1 → NP_001416016.1  ARF GTPase-activating protein GIT2 isoform 34

    Status: VALIDATED

    Source sequence(s)
    AC087330

  34. NM_019834.4 → NP_062808.3  ARF GTPase-activating protein GIT2 isoform 1

    See identical proteins and their annotated locations for NP_062808.3

    Status: VALIDATED

    Source sequence(s)
    AC087330
    Consensus CDS
    CCDS19570.2
    UniProtKB/Swiss-Prot
    E9QPU7, Q9JLQ2
    UniProtKB/TrEMBL
    J3QK07
    Related
    ENSMUSP00000107803.3, ENSMUST00000112185.9
    Conserved Domains (6) summary
    smart00105
    Location:2 → 124
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    cd00204
    Location:109 → 220
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam08518
    Location:265 → 293
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:587 → 701
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    114865469..114912647 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530331.4 → XP_006530394.1  ARF GTPase-activating protein GIT2 isoform X2

    UniProtKB/TrEMBL
    J3QK07
    Conserved Domains (6) summary
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    cd08847
    Location:1 → 111
    ArfGap_GIT2; GIT2 GTPase activating protein for Arf
    pfam08518
    Location:267 → 295
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:639 → 753
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    pfam16559
    Location:415 → 479
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

  2. XM_006530334.4 → XP_006530397.1  ARF GTPase-activating protein GIT2 isoform X4

    UniProtKB/TrEMBL
    J3QK07
    Conserved Domains (6) summary
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    cd08847
    Location:1 → 111
    ArfGap_GIT2; GIT2 GTPase activating protein for Arf
    pfam08518
    Location:268 → 296
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:625 → 739
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    pfam16559
    Location:416 → 465
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

  3. XM_006530335.4 → XP_006530398.1  ARF GTPase-activating protein GIT2 isoform X7

    UniProtKB/TrEMBL
    J3QK07
    Conserved Domains (6) summary
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    cd08847
    Location:1 → 111
    ArfGap_GIT2; GIT2 GTPase activating protein for Arf
    pfam08518
    Location:268 → 296
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:610 → 724
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    pfam16559
    Location:416 → 480
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

  4. XM_006530339.4 → XP_006530402.1  ARF GTPase-activating protein GIT2 isoform X1

    UniProtKB/TrEMBL
    J3QK07
    Conserved Domains (6) summary
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    cd08847
    Location:1 → 111
    ArfGap_GIT2; GIT2 GTPase activating protein for Arf
    pfam08518
    Location:268 → 296
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:640 → 754
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    pfam16559
    Location:416 → 480
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

  5. XM_030254527.1 → XP_030110387.1  ARF GTPase-activating protein GIT2 isoform X17

    UniProtKB/TrEMBL
    J3QK07
    Related
    ENSMUSP00000136796.2, ENSMUST00000178440.8
    Conserved Domains (5) summary
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    cd08847
    Location:1 → 111
    ArfGap_GIT2; GIT2 GTPase activating protein for Arf
    pfam08518
    Location:265 → 293
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:557 → 671
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)

  6. XM_030254522.2 → XP_030110382.1  ARF GTPase-activating protein GIT2 isoform X6

    UniProtKB/TrEMBL
    J3QK07
    Conserved Domains (6) summary
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    cd08847
    Location:1 → 111
    ArfGap_GIT2; GIT2 GTPase activating protein for Arf
    pfam08518
    Location:265 → 293
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:622 → 736
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    pfam16559
    Location:413 → 462
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

  7. XM_006530333.5 → XP_006530396.1  ARF GTPase-activating protein GIT2 isoform X3

    UniProtKB/TrEMBL
    J3QK07
    Conserved Domains (6) summary
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    cd08847
    Location:1 → 111
    ArfGap_GIT2; GIT2 GTPase activating protein for Arf
    pfam08518
    Location:265 → 293
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:637 → 751
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    pfam16559
    Location:413 → 477
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

  8. XM_017320893.3 → XP_017176382.1  ARF GTPase-activating protein GIT2 isoform X12

    UniProtKB/TrEMBL
    J3QK07
    Conserved Domains (5) summary
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    cd08847
    Location:1 → 111
    ArfGap_GIT2; GIT2 GTPase activating protein for Arf
    pfam08518
    Location:266 → 294
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:588 → 702
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)

  9. XM_030254520.2 → XP_030110380.1  ARF GTPase-activating protein GIT2 isoform X5

    UniProtKB/TrEMBL
    J3QK07
    Conserved Domains (6) summary
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    cd08847
    Location:1 → 111
    ArfGap_GIT2; GIT2 GTPase activating protein for Arf
    pfam08518
    Location:266 → 294
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:623 → 737
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    pfam16559
    Location:414 → 463
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

  10. XM_006530336.5 → XP_006530399.1  ARF GTPase-activating protein GIT2 isoform X8

    UniProtKB/TrEMBL
    J3QK07
    Conserved Domains (6) summary
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    cd08847
    Location:1 → 111
    ArfGap_GIT2; GIT2 GTPase activating protein for Arf
    pfam08518
    Location:266 → 294
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:608 → 722
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    pfam16559
    Location:414 → 478
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

  11. XM_006530338.5 → XP_006530401.1  ARF GTPase-activating protein GIT2 isoform X16

    UniProtKB/TrEMBL
    D3Z1I2, J3QK07
    Related
    ENSMUSP00000107801.2, ENSMUST00000112183.8
    Conserved Domains (5) summary
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    cd08847
    Location:1 → 111
    ArfGap_GIT2; GIT2 GTPase activating protein for Arf
    pfam08518
    Location:268 → 296
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:560 → 674
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)

  12. XM_006530337.5 → XP_006530400.1  ARF GTPase-activating protein GIT2 isoform X11

    UniProtKB/TrEMBL
    J3QK07
    Conserved Domains (5) summary
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    cd08847
    Location:1 → 111
    ArfGap_GIT2; GIT2 GTPase activating protein for Arf
    pfam08518
    Location:268 → 296
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:590 → 704
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)

  13. XM_030254524.2 → XP_030110384.1  ARF GTPase-activating protein GIT2 isoform X10

    UniProtKB/TrEMBL
    J3QK07
    Conserved Domains (6) summary
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    cd08847
    Location:1 → 111
    ArfGap_GIT2; GIT2 GTPase activating protein for Arf
    pfam08518
    Location:268 → 296
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:595 → 709
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    pfam16559
    Location:416 → 465
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

  14. XM_030254526.2 → XP_030110386.1  ARF GTPase-activating protein GIT2 isoform X15

    UniProtKB/TrEMBL
    J3QK07
    Conserved Domains (6) summary
    sd00045
    Location:75 → 103
    ANK; ANK repeat [structural motif]
    cl28907
    Location:1 → 49
    ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
    pfam08518
    Location:203 → 231
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:575 → 689
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:75 → 167
    Ank_2; Ankyrin repeats (3 copies)
    pfam16559
    Location:351 → 415
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

  15. XM_036165144.1 → XP_036021037.1  ARF GTPase-activating protein GIT2 isoform X14

    UniProtKB/TrEMBL
    J3QK07
    Conserved Domains (6) summary
    sd00045
    Location:75 → 103
    ANK; ANK repeat [structural motif]
    cl28907
    Location:1 → 49
    ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
    pfam08518
    Location:204 → 232
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:574 → 690
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:75 → 167
    Ank_2; Ankyrin repeats (3 copies)
    pfam16559
    Location:352 → 416
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

  16. XM_030254525.2 → XP_030110385.1  ARF GTPase-activating protein GIT2 isoform X13

    UniProtKB/TrEMBL
    J3QK07
    Conserved Domains (6) summary
    sd00045
    Location:75 → 103
    ANK; ANK repeat [structural motif]
    cl28907
    Location:1 → 49
    ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
    pfam08518
    Location:206 → 234
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:578 → 692
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:75 → 167
    Ank_2; Ankyrin repeats (3 copies)
    pfam16559
    Location:354 → 418
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

  17. XM_030254529.2 → XP_030110389.1  ARF GTPase-activating protein GIT2 isoform X19

    UniProtKB/TrEMBL
    J3QK07
    Conserved Domains (5) summary
    sd00045
    Location:75 → 103
    ANK; ANK repeat [structural motif]
    cl28907
    Location:1 → 49
    ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
    pfam08518
    Location:203 → 231
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:525 → 639
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:75 → 167
    Ank_2; Ankyrin repeats (3 copies)

  18. XM_030254530.2 → XP_030110390.1  ARF GTPase-activating protein GIT2 isoform X20

    UniProtKB/TrEMBL
    J3QK07
    Conserved Domains (5) summary
    sd00045
    Location:75 → 103
    ANK; ANK repeat [structural motif]
    cl28907
    Location:1 → 49
    ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
    pfam08518
    Location:204 → 232
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:496 → 610
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:75 → 167
    Ank_2; Ankyrin repeats (3 copies)

  19. XM_030254528.2 → XP_030110388.1  ARF GTPase-activating protein GIT2 isoform X18

    UniProtKB/TrEMBL
    J3QK07
    Conserved Domains (5) summary
    sd00045
    Location:75 → 103
    ANK; ANK repeat [structural motif]
    cl28907
    Location:1 → 49
    ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
    pfam08518
    Location:204 → 232
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:526 → 640
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:75 → 167
    Ank_2; Ankyrin repeats (3 copies)

  20. XM_030254523.2 → XP_030110383.1  ARF GTPase-activating protein GIT2 isoform X9

    UniProtKB/TrEMBL
    J3QK07
    Related
    ENSMUSP00000122302.3, ENSMUST00000155908.8
    Conserved Domains (6) summary
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    cd08847
    Location:1 → 111
    ArfGap_GIT2; GIT2 GTPase activating protein for Arf
    pfam08518
    Location:265 → 293
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:607 → 721
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    pfam16559
    Location:413 → 477
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JLQ2.2 GenPept UniProtKB/Swiss-Prot:Q9JLQ2

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