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Map4k2 mitogen-activated protein kinase kinase kinase kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 26412, updated on 11-Apr-2024

Summary

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Official Symbol
Map4k2provided by MGI
Official Full Name
mitogen-activated protein kinase kinase kinase kinase 2provided by MGI
Primary source
MGI:MGI:1346883
See related
Ensembl:ENSMUSG00000024948 AllianceGenome:MGI:1346883
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GCK; BL44; Rab8ip
Summary
Predicted to enable ATP binding activity; MAP kinase kinase kinase kinase activity; and mitogen-activated protein kinase kinase kinase binding activity. Involved in vesicle targeting. Predicted to be located in Golgi apparatus and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human MAP4K2 (mitogen-activated protein kinase kinase kinase kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 169.4), spleen adult (RPKM 142.6) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 A; 19 4.46 cM
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (6391023..6405649)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (6340990..6355619)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5682 Neighboring gene CDC42 binding protein kinase gamma Neighboring gene STARR-positive B cell enhancer ABC_E11670 Neighboring gene STARR-positive B cell enhancer ABC_E3239 Neighboring gene STARR-positive B cell enhancer ABC_E11015 Neighboring gene multiple endocrine neoplasia 1 Neighboring gene microRNA 6989 Neighboring gene predicted gene 14966 Neighboring gene STARR-positive B cell enhancer ABC_E1209 Neighboring gene predicted gene, 57665 Neighboring gene splicing factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. In its active form, the GTP-binding protein rab8 interacts with a stress-activated protein kinase. Ren M, et al. Proc Natl Acad Sci U S A, 1996 May 14. PMID 8643544, Free PMC Article
  2. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
  3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC143893, MGC143894

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables MAP kinase kinase kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables mitogen-activated protein kinase kinase kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of JUN kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle targeting IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mitogen-activated protein kinase kinase kinase kinase 2
Names
MAPK/ERK kinase kinase kinase 2
MEK kinase kinase 2
MEKKK 2
RAB8 interacting protein
germinal center kinase
rab8-interacting protein
NP_001278716.1
NP_001402757.1
NP_033032.1
XP_006531818.1
XP_006531819.1
XP_006531820.1
XP_006531823.1
XP_017173700.1
XP_017173701.1
XP_036017493.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291787.2 → NP_001278716.1  mitogen-activated protein kinase kinase kinase kinase 2 isoform 2

    See identical proteins and their annotated locations for NP_001278716.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC127556
    UniProtKB/TrEMBL
    Q3U4B8
    Conserved Domains (2) summary
    smart00036
    Location:400 → 712
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:1 → 183
    PKc_like; Protein Kinases, catalytic domain

  2. NM_001415828.1 → NP_001402757.1  mitogen-activated protein kinase kinase kinase kinase 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC127556

  3. NM_009006.4 → NP_033032.1  mitogen-activated protein kinase kinase kinase kinase 2 isoform 1

    See identical proteins and their annotated locations for NP_033032.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC127556
    Consensus CDS
    CCDS29503.1
    UniProtKB/Swiss-Prot
    Q61161
    UniProtKB/TrEMBL
    Q3U4B8
    Related
    ENSMUSP00000025897.7, ENSMUST00000025897.13
    Conserved Domains (3) summary
    smart00036
    Location:489 → 801
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:16 → 272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06613
    Location:16 → 272
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

RNA

  1. NR_117093.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) retains an intron and uses an alternate splice junction at the 3' end of an exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC127556, AK011708, AK051036, BC034109, BY753233

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    6391023..6405649
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531755.4 → XP_006531818.1  mitogen-activated protein kinase kinase kinase kinase 2 isoform X2

    See identical proteins and their annotated locations for XP_006531818.1

    UniProtKB/TrEMBL
    Q3U4B8
    Conserved Domains (2) summary
    smart00036
    Location:434 → 746
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:50 → 217
    PKc_like; Protein Kinases, catalytic domain

  2. XM_036161600.1 → XP_036017493.1  mitogen-activated protein kinase kinase kinase kinase 2 isoform X3

    UniProtKB/TrEMBL
    Q3U4B8
    Related
    ENSMUST00000133696.8
    Conserved Domains (2) summary
    smart00036
    Location:423 → 735
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:39 → 206
    PKc_like; Protein Kinases, catalytic domain

  3. XM_017318211.3 → XP_017173700.1  mitogen-activated protein kinase kinase kinase kinase 2 isoform X1

    UniProtKB/TrEMBL
    Q14B83, Q3U4B8
    Conserved Domains (2) summary
    smart00036
    Location:445 → 757
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:38 → 228
    PKc_like; Protein Kinases, catalytic domain

  4. XM_006531760.5 → XP_006531823.1  mitogen-activated protein kinase kinase kinase kinase 2 isoform X4

    See identical proteins and their annotated locations for XP_006531823.1

    UniProtKB/TrEMBL
    Q3U4B8
    Conserved Domains (2) summary
    smart00036
    Location:400 → 712
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:1 → 183
    PKc_like; Protein Kinases, catalytic domain

  5. XM_017318212.2 → XP_017173701.1  mitogen-activated protein kinase kinase kinase kinase 2 isoform X1

    UniProtKB/TrEMBL
    Q14B83, Q3U4B8
    Conserved Domains (2) summary
    smart00036
    Location:445 → 757
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:38 → 228
    PKc_like; Protein Kinases, catalytic domain

  6. XM_006531756.4 → XP_006531819.1  mitogen-activated protein kinase kinase kinase kinase 2 isoform X2

    See identical proteins and their annotated locations for XP_006531819.1

    UniProtKB/TrEMBL
    Q3U4B8
    Conserved Domains (2) summary
    smart00036
    Location:434 → 746
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:50 → 217
    PKc_like; Protein Kinases, catalytic domain

  7. XM_006531757.2 → XP_006531820.1  mitogen-activated protein kinase kinase kinase kinase 2 isoform X2

    See identical proteins and their annotated locations for XP_006531820.1

    UniProtKB/TrEMBL
    Q3U4B8
    Conserved Domains (2) summary
    smart00036
    Location:434 → 746
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:50 → 217
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_001782591.3 RNA Sequence

    Related
    ENSMUST00000124556.8
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61161.1 GenPept UniProtKB/Swiss-Prot:Q61161

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