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Adgre5 adhesion G protein-coupled receptor E5 [ Mus musculus (house mouse) ]

Gene ID: 26364, updated on 21-Apr-2024

Summary

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Official Symbol
Adgre5provided by MGI
Official Full Name
adhesion G protein-coupled receptor E5provided by MGI
Primary source
MGI:MGI:1347095
See related
Ensembl:ENSMUSG00000002885 AllianceGenome:MGI:1347095
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cd97; TM7LN1
Summary
Predicted to enable G protein-coupled receptor activity and chondroitin sulfate binding activity. Acts upstream of or within positive regulation of synapse assembly. Located in external side of plasma membrane. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and immune system. Human ortholog(s) of this gene implicated in vibratory urticaria. Orthologous to several human genes including ADGRE5 (adhesion G protein-coupled receptor E5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lung adult (RPKM 217.2), spleen adult (RPKM 95.9) and 14 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 C2; 8 40.22 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (84449874..84467812, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (83723245..83741311, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1372 Neighboring gene GIPC PDZ domain containing family, member 1 Neighboring gene STARR-positive B cell enhancer ABC_E11744 Neighboring gene prostaglandin E receptor 1 (subtype EP1) Neighboring gene protein kinase N1 Neighboring gene STARR-positive B cell enhancer ABC_E9319 Neighboring gene STARR-seq mESC enhancer starr_22095 Neighboring gene STARR-positive B cell enhancer ABC_E562 Neighboring gene DEAD box helicase 39a Neighboring gene microRNA 1668 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:86260655-86260859 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:86263836-86264037 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:86271935-86272044 Neighboring gene predicted gene, 46046 Neighboring gene STARR-positive B cell enhancer ABC_E10 Neighboring gene predicted gene, 42030

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CD97 stabilises the immunological synapse between dendritic cells and T cells and is targeted for degradation by the Salmonella effector SteD. Cerny O, et al. PLoS Pathog, 2021 Jul. PMID 34314469, Free PMC Article
  2. Contradictory Role of CD97 in Basal and Tumor Necrosis Factor-Induced Osteoclastogenesis In Vivo. Yeon Won H, et al. Arthritis Rheumatol, 2016 May. PMID 26663852, Free PMC Article
  3. Mice overexpressing CD97 in intestinal epithelial cells provide a unique model for mammalian postnatal intestinal cylindrical growth. Aust G, et al. Mol Biol Cell, 2013 Jul. PMID 23676664, Free PMC Article
  4. Overexpression of CD97 in intestinal epithelial cells of transgenic mice attenuates colitis by strengthening adherens junctions. Becker S, et al. PLoS One, 2010 Jan 13. PMID 20084281, Free PMC Article
  5. Therapeutic antibody targeting of CD97 in experimental arthritis: the role of antigen expression, shedding, and internalization on the pharmacokinetics of anti-CD97 monoclonal antibody 1B2. de Groot DM, et al. J Immunol, 2009 Sep 15. PMID 19717518

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CD97 negatively regulates the innate immune response against RNA viruses by promoting RNF125-mediated RIG-I degradation.
    Title: CD97 negatively regulates the innate immune response against RNA viruses by promoting RNF125-mediated RIG-I degradation.
  2. CD97 promotes spleen dendritic cell homeostasis through the mechanosensing of red blood cells.
    Title: CD97 promotes spleen dendritic cell homeostasis through the mechanosensing of red blood cells.
  3. CD97 stabilises the immunological synapse between dendritic cells and T cells and is targeted for degradation by the Salmonella effector SteD.
    Title: CD97 stabilises the immunological synapse between dendritic cells and T cells and is targeted for degradation by the Salmonella effector SteD.
  4. How to Obtain a Mega-Intestine with Normal Morphology: In Silico Modelling of Postnatal Intestinal Growth in a Cd97-Transgenic Mouse.
    Title: How to Obtain a Mega-Intestine with Normal Morphology: In Silico Modelling of Postnatal Intestinal Growth in a Cd97-Transgenic Mouse.
  5. These findings demonstrate that CD97 is a positive regulator of osteoclast-like cell differentiation, a mechanism that influences bone homeostasis. However, the presence of CD97 may be essential to suppress the initial osteoclastogenesis that occurs in response to acute and local inflammatory stimuli.
    Title: Contradictory Role of CD97 in Basal and Tumor Necrosis Factor-Induced Osteoclastogenesis In Vivo.
  6. We conclude that CD97 is located in the SR and at the peripheral sarcolemma of human and murine skeletal muscle, where its absence affects the structure of the SR without impairing skeletal muscle function
    Title: Skeletal muscle expression of the adhesion-GPCR CD97: CD97 deletion induces an abnormal structure of the sarcoplasmatic reticulum but does not impair skeletal muscle function.
  7. Intestinal enlargement by CD97 requires its seven-span transmembrane/cytoplasmic C-terminal fragment.
    Title: Mice overexpressing CD97 in intestinal epithelial cells provide a unique model for mammalian postnatal intestinal cylindrical growth.
  8. CD55 downregulates CD97 surface expression on circulating leukocytes by a process that requires physical forces.
    Title: Shear stress-dependent downregulation of the adhesion-G protein-coupled receptor CD97 on circulating leukocytes upon contact with its ligand CD55.
  9. Insight into a role for CD55 interaction with CD97 in the pathogenesis of rheumatoid arthritis suggest that therapeutic strategies that disrupt CD55/CD97 may be clinically beneficial.
    Title: Deletion of either CD55 or CD97 ameliorates arthritis in mouse models.
  10. Despite the broad expression pattern of wild-type murine CD97, the successfully deleted gene Cd97-deficient mouse that is created has no overt phenotype, except for a mild granulocytosis that is normal in the absence of CD97.
    Title: Analysis of CD97 expression and manipulation: antibody treatment but not gene targeting curtails granulocyte migration.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables chondroitin sulfate binding ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane signaling receptor activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of synapse assembly IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in leading edge membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
adhesion G protein-coupled receptor E5
Names
CD97 antigen
EGF-TM7 receptor
leukocyte antigen CD97

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163029.2 → NP_001156501.1  adhesion G protein-coupled receptor E5 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001156501.1

    Status: VALIDATED

    Source sequence(s)
    AC164432
    Consensus CDS
    CCDS52610.1
    UniProtKB/TrEMBL
    A0A0D9SEG8, Q4FJS6
    Related
    ENSMUSP00000002964.8, ENSMUST00000002964.14
    Conserved Domains (3) summary
    pfam00002
    Location:432 → 672
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam01825
    Location:386 → 424
    GPS; GPCR proteolysis site, GPS, motif
    pfam07645
    Location:120 → 154
    EGF_CA; Calcium-binding EGF domain

  2. NM_001163030.2 → NP_001156502.1  adhesion G protein-coupled receptor E5 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC164432
    Consensus CDS
    CCDS52611.1
    UniProtKB/Swiss-Prot
    Q923A1, Q9CVI5, Q9JLQ8, Q9Z0M6
    UniProtKB/TrEMBL
    E9QMJ5
    Related
    ENSMUSP00000105427.3, ENSMUST00000109802.3
    Conserved Domains (3) summary
    pfam00002
    Location:481 → 721
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam01825
    Location:435 → 473
    GPS; GPCR proteolysis site, GPS, motif
    pfam07645
    Location:120 → 167
    EGF_CA; Calcium-binding EGF domain

  3. NM_001163031.2 → NP_001156503.1  adhesion G protein-coupled receptor E5 isoform 4 precursor

    See identical proteins and their annotated locations for NP_001156503.1

    Status: VALIDATED

    Source sequence(s)
    AC164432
    Consensus CDS
    CCDS52612.1
    UniProtKB/TrEMBL
    Q4FJS6, Q9DC42
    Related
    ENSMUSP00000128220.2, ENSMUST00000166939.8
    Conserved Domains (3) summary
    pfam00002
    Location:430 → 670
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam01825
    Location:384 → 422
    GPS; GPCR proteolysis site, GPS, motif
    pfam07645
    Location:118 → 152
    EGF_CA; Calcium-binding EGF domain

  4. NM_001414296.1 → NP_001401225.1  adhesion G protein-coupled receptor E5 isoform 5 precursor

    Status: VALIDATED

    Source sequence(s)
    AC164432

  5. NM_001414297.1 → NP_001401226.1  adhesion G protein-coupled receptor E5 isoform 6 precursor

    Status: VALIDATED

    Source sequence(s)
    AC164432

  6. NM_001414298.1 → NP_001401227.1  adhesion G protein-coupled receptor E5 isoform 7 precursor

    Status: VALIDATED

    Source sequence(s)
    AC164432

  7. NM_001414300.1 → NP_001401229.1  adhesion G protein-coupled receptor E5 isoform 9 precursor

    Status: VALIDATED

    Source sequence(s)
    AC164432

  8. NM_001414301.1 → NP_001401230.1  adhesion G protein-coupled receptor E5 isoform 10 precursor

    Status: VALIDATED

    Source sequence(s)
    AC164432

  9. NM_001414302.1 → NP_001401231.1  adhesion G protein-coupled receptor E5 isoform 11 precursor

    Status: VALIDATED

    Source sequence(s)
    AC164432

  10. NM_011925.3 → NP_036055.2  adhesion G protein-coupled receptor E5 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC164432
    Consensus CDS
    CCDS22461.1
    UniProtKB/Swiss-Prot
    Q923A1, Q9CVI5, Q9JLQ8, Q9Z0M6
    UniProtKB/TrEMBL
    E9QJS7
    Related
    ENSMUSP00000075240.7, ENSMUST00000075843.13
    Conserved Domains (3) summary
    pfam00002
    Location:526 → 766
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam01825
    Location:480 → 518
    GPS; GPCR proteolysis site, GPS, motif
    pfam07645
    Location:165 → 212
    EGF_CA; Calcium-binding EGF domain

RNA

  1. NR_183247.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC164432

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    84449874..84467812 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z0M6.2 GenPept UniProtKB/Swiss-Prot:Q9Z0M6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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