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WWTR1 WW domain containing transcription regulator 1 [ Homo sapiens (human) ]

Gene ID: 25937, updated on 12-Apr-2024

Summary

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Official Symbol
WWTR1provided by HGNC
Official Full Name
WW domain containing transcription regulator 1provided by HGNC
Primary source
HGNC:HGNC:24042
See related
Ensembl:ENSG00000018408 MIM:607392; AllianceGenome:HGNC:24042
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TAZ
Summary
Enables transcription coactivator activity. Involved in several processes, including hippo signaling; positive regulation of cell differentiation; and regulation of signal transduction. Located in cytosol and nuclear body. [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: TAZ (GeneID 6901) and WWTR1 (GeneID 25937) loci share the TAZ symbol/alias in common. TAZ is a widely used alternative name for the transcriptional coactivator with PDZ-binding motif (WWTR1) conflicting with the official symbol for tafazzin (TAZ). [19 Jun 2012]
Expression
Ubiquitous expression in gall bladder (RPKM 24.8), endometrium (RPKM 22.7) and 24 other tissues See more
Orthologs
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Genomic context

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See WWTR1 in Genome Data Viewer
Location:
3q25.1
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (149517235..149724788, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (152268462..152476040, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (149235022..149442575, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:149181411-149181912 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:149181913-149182412 Neighboring gene Sharpr-MPRA regulatory region 13408 Neighboring gene FKBP prolyl isomerase 1A pseudogene 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14803 Neighboring gene Sharpr-MPRA regulatory region 15242 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14804 Neighboring gene transmembrane 4 L six family member 4 Neighboring gene Sharpr-MPRA regulatory region 15061 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 45 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14805 Neighboring gene RNA, U6 small nuclear 1098, pseudogene Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr3:149291956-149292582 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:149292583-149293209 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:149293210-149293836 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:149322409-149323099 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:149369611-149370110 Neighboring gene Sharpr-MPRA regulatory region 14320 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:149375639-149376218 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20682 Neighboring gene WWTR1 intronic transcript 1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:149388438-149388978 Neighboring gene WWTR1 antisense RNA 1 Neighboring gene NANOG hESC enhancer GRCh37_chr3:149396068-149396569 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:149431193-149431694 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:149431695-149432194 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14807 Neighboring gene COMM domain containing 2 Neighboring gene ankyrin repeat and ubiquitin domain containing 1 Neighboring gene RNA, U6 small nuclear 507, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Hypoxia Triggers TAZ Phosphorylation in Basal A Triple Negative Breast Cancer Cells. Liu Q, et al. Int J Mol Sci, 2022 Sep 4. PMID 36077517, Free PMC Article
  2. Hippo signaling cofactor, WWTR1, at the crossroads of human trophoblast progenitor self-renewal and differentiation. Ray S, et al. Proc Natl Acad Sci U S A, 2022 Sep 6. PMID 36037374, Free PMC Article
  3. TAZ Reduces UVA-mediated Photoaging through Regulates Cell Proliferation in Skin Fibroblasts. Wang M, et al. Photochem Photobiol, 2023 Jan. PMID 35598174
  4. Activated TAZ induces liver cancer in collaboration with EGFR/HER2 signaling pathways. Moon H, et al. BMC Cancer, 2022 Apr 19. PMID 35439973, Free PMC Article
  5. Recurrent WWTR1 S89W mutations and Hippo pathway deregulation in clear cell carcinomas of the cervix. Kim SH, et al. J Pathol, 2022 Aug. PMID 35411948, Free PMC Article

See all (410) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. VGLL1 stabilization of cytoplasmic TAZ promotes EGFR expression and maintains tumor initiating cells in breast cancer independent of TEAD.
    Title: VGLL1 stabilization of cytoplasmic TAZ promotes EGFR expression and maintains tumor initiating cells in breast cancer independent of TEAD.
  2. EID3 inhibits the osteogenic differentiation of periodontal ligament stem cells and mediates the signal transduction of TAZ-EID3-AKT/MTOR/ERK.
    Title: EID3 inhibits the osteogenic differentiation of periodontal ligament stem cells and mediates the signal transduction of TAZ-EID3-AKT/MTOR/ERK.
  3. SEPTIN10-mediated crosstalk between cytoskeletal networks controls mechanotransduction and oncogenic YAP/TAZ signaling.
    Title: SEPTIN10-mediated crosstalk between cytoskeletal networks controls mechanotransduction and oncogenic YAP/TAZ signaling.
  4. Downregulation of TAZ elicits a mitochondrial redox imbalance and ferroptosis in lung epithelial cells exposed to diesel exhaust particles.
    Title: Downregulation of TAZ elicits a mitochondrial redox imbalance and ferroptosis in lung epithelial cells exposed to diesel exhaust particles.
  5. Transcriptomics analysis revealed that TAZ regulates the proliferation of KIRC cells through mitophagy.
    Title: Transcriptomics analysis revealed that TAZ regulates the proliferation of KIRC cells through mitophagy.
  6. Knockdown of CCM3 promotes angiogenesis through activation and nuclear translocation of YAP/TAZ.
    Title: Knockdown of CCM3 promotes angiogenesis through activation and nuclear translocation of YAP/TAZ.
  7. TAZ acting as a potential pathogenic biomarker to promote the development of lichen planus.
    Title: TAZ acting as a potential pathogenic biomarker to promote the development of lichen planus.
  8. M2 macrophages promote subconjunctival fibrosis through YAP/TAZ signalling.
    Title: M2 macrophages promote subconjunctival fibrosis through YAP/TAZ signalling.
  9. Tankyrase inhibition interferes with junction remodeling, induces leakiness, and disturbs YAP1/TAZ signaling in the endothelium.
    Title: Tankyrase inhibition interferes with junction remodeling, induces leakiness, and disturbs YAP1/TAZ signaling in the endothelium.
  10. Targeting YAP/TAZ mechanosignaling to ameliorate stiffness-induced Schlemm's canal cell pathobiology.
    Title: Targeting YAP/TAZ mechanosignaling to ameliorate stiffness-induced Schlemm's canal cell pathobiology.
Submit: New GeneRIF Correction See all GeneRIFs (376)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of pre-eclampsia detects novel maternal single nucleotide polymorphisms and copy-number variants in subsets of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study cohort.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of WW domain containing transcription regulator 1 (WWTR1; TAZ) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ27004, FLJ45718, DKFZp586I1419

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coactivator activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in SMAD protein signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cilium assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in glomerulus development IEA
Inferred from Electronic Annotation
more info
  
involved_in heart process IEA
Inferred from Electronic Annotation
more info
  
involved_in hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hippo signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in kidney morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in mesenchymal cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in multicellular organism growth IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of fat cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of protein kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of epithelial to mesenchymal transition IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of osteoblast differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of protein localization to nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of metanephric nephron tubule epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in stem cell division IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tissue homeostasis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nuclear body IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of transcription regulator complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
WW domain-containing transcription regulator protein 1
Names
transcriptional co-activator with PDZ-binding motif

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168278.3 → NP_001161750.1  WW domain-containing transcription regulator protein 1

    See identical proteins and their annotated locations for NP_001161750.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 4. Variants 1 through 4 all encode the same protein.
    Source sequence(s)
    AC012014, AK022036, AK130514, AL833852, DA338432
    Consensus CDS
    CCDS3144.1
    UniProtKB/Swiss-Prot
    D3DNH7, Q8N3P2, Q9GZV5, Q9Y3W6
    Related
    ENSP00000419465.1, ENST00000465804.5
    Conserved Domains (1) summary
    smart00456
    Location:125 → 156
    WW; Domain with 2 conserved Trp (W) residues

  2. NM_001168280.3 → NP_001161752.1  WW domain-containing transcription regulator protein 1

    See identical proteins and their annotated locations for NP_001161752.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 4. Variants 1 through 4 all encode the same protein.
    Source sequence(s)
    AC012014, AL833852, DA854089
    Consensus CDS
    CCDS3144.1
    UniProtKB/Swiss-Prot
    D3DNH7, Q8N3P2, Q9GZV5, Q9Y3W6
    Related
    ENSP00000419234.1, ENST00000467467.5
    Conserved Domains (1) summary
    smart00456
    Location:125 → 156
    WW; Domain with 2 conserved Trp (W) residues

  3. NM_001348362.2 → NP_001335291.1  WW domain-containing transcription regulator protein 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longest transcript. Variants 1 through 4 all encode the same protein.
    Source sequence(s)
    AC012014, AC069216, AC108672, BQ003163
    Consensus CDS
    CCDS3144.1
    UniProtKB/Swiss-Prot
    D3DNH7, Q8N3P2, Q9GZV5, Q9Y3W6
    Conserved Domains (1) summary
    smart00456
    Location:125 → 156
    WW; Domain with 2 conserved Trp (W) residues

  4. NM_015472.6 → NP_056287.1  WW domain-containing transcription regulator protein 1

    See identical proteins and their annotated locations for NP_056287.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant 12) differs in the 5' UTR compared to variant 4. Variants 1 through 4 all encode the same protein.
    Source sequence(s)
    AC012014, AK130514, AL833852, BC014052, DA760311
    Consensus CDS
    CCDS3144.1
    UniProtKB/Swiss-Prot
    D3DNH7, Q8N3P2, Q9GZV5, Q9Y3W6
    Related
    ENSP00000353847.3, ENST00000360632.8
    Conserved Domains (1) summary
    smart00456
    Location:125 → 156
    WW; Domain with 2 conserved Trp (W) residues

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    149517235..149724788 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047447933.1 → XP_047303889.1  WW domain-containing transcription regulator protein 1 isoform X1

    UniProtKB/Swiss-Prot
    D3DNH7, Q8N3P2, Q9GZV5, Q9Y3W6

  2. XM_047447931.1 → XP_047303887.1  WW domain-containing transcription regulator protein 1 isoform X1

    UniProtKB/Swiss-Prot
    D3DNH7, Q8N3P2, Q9GZV5, Q9Y3W6

  3. XM_047447932.1 → XP_047303888.1  WW domain-containing transcription regulator protein 1 isoform X1

    UniProtKB/Swiss-Prot
    D3DNH7, Q8N3P2, Q9GZV5, Q9Y3W6

  4. XM_017006122.2 → XP_016861611.1  WW domain-containing transcription regulator protein 1 isoform X1

    UniProtKB/Swiss-Prot
    D3DNH7, Q8N3P2, Q9GZV5, Q9Y3W6
    Conserved Domains (1) summary
    smart00456
    Location:125 → 156
    WW; Domain with 2 conserved Trp (W) residues

  5. XM_047447930.1 → XP_047303886.1  WW domain-containing transcription regulator protein 1 isoform X1

    UniProtKB/Swiss-Prot
    D3DNH7, Q8N3P2, Q9GZV5, Q9Y3W6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    152268462..152476040 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054346105.1 → XP_054202080.1  WW domain-containing transcription regulator protein 1 isoform X2

    UniProtKB/Swiss-Prot
    D3DNH7, Q8N3P2, Q9GZV5, Q9Y3W6

  2. XM_054346110.1 → XP_054202085.1  WW domain-containing transcription regulator protein 1 isoform X2

    UniProtKB/Swiss-Prot
    D3DNH7, Q8N3P2, Q9GZV5, Q9Y3W6

  3. XM_054346108.1 → XP_054202083.1  WW domain-containing transcription regulator protein 1 isoform X2

    UniProtKB/Swiss-Prot
    D3DNH7, Q8N3P2, Q9GZV5, Q9Y3W6

  4. XM_054346109.1 → XP_054202084.1  WW domain-containing transcription regulator protein 1 isoform X2

    UniProtKB/Swiss-Prot
    D3DNH7, Q8N3P2, Q9GZV5, Q9Y3W6

  5. XM_054346106.1 → XP_054202081.1  WW domain-containing transcription regulator protein 1 isoform X2

    UniProtKB/Swiss-Prot
    D3DNH7, Q8N3P2, Q9GZV5, Q9Y3W6

  6. XM_054346107.1 → XP_054202082.1  WW domain-containing transcription regulator protein 1 isoform X2

    UniProtKB/Swiss-Prot
    D3DNH7, Q8N3P2, Q9GZV5, Q9Y3W6

  7. XM_054346104.1 → XP_054202079.1  WW domain-containing transcription regulator protein 1 isoform X2

    UniProtKB/Swiss-Prot
    D3DNH7, Q8N3P2, Q9GZV5, Q9Y3W6

  8. XM_054346103.1 → XP_054202078.1  WW domain-containing transcription regulator protein 1 isoform X2

    UniProtKB/Swiss-Prot
    D3DNH7, Q8N3P2, Q9GZV5, Q9Y3W6
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9GZV5.1 GenPept UniProtKB/Swiss-Prot:Q9GZV5

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