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Cpt1b carnitine palmitoyltransferase 1B [ Rattus norvegicus (Norway rat) ]

Gene ID: 25756, updated on 3-Apr-2024

Summary

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Official Symbol
Cpt1bprovided by RGD
Official Full Name
carnitine palmitoyltransferase 1Bprovided by RGD
Primary source
RGD:2397
See related
Ensembl:ENSRNOG00000010438 AllianceGenome:RGD:2397
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CPT-IB; M-CPTI
Summary
Enables carnitine O-palmitoyltransferase activity. Involved in long-chain fatty acid transport. Located in mitochondrion. Orthologous to human CPT1B (carnitine palmitoyltransferase 1B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 1258.7), Muscle (RPKM 636.5) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
7q34
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (122370974..122380473, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (120491354..120500833, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (130395211..130404731, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene kelch domain containing 7B Neighboring gene synaptonemal complex central element protein 3 Neighboring gene uncharacterized LOC134479955 Neighboring gene choline kinase beta Neighboring gene uncharacterized LOC134479956 Neighboring gene mitogen-activated protein kinase 8 interacting protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Antilipolytic and antilipogenic effects of the CPT-1b inhibitor oxfenicine in the white adipose tissue of rats. Sepa-Kishi DM, et al. Am J Physiol Regul Integr Comp Physiol, 2016 Oct 1. PMID 27558315, Free PMC Article
  2. Impaired oxidative capacity due to decreased CPT1b levels as a contributing factor to fat accumulation in obesity. Ratner C, et al. Am J Physiol Regul Integr Comp Physiol, 2015 Jun 1. PMID 25855307
  3. Identification of a novel malonyl-CoA IC(50) for CPT-I: implications for predicting in vivo fatty acid oxidation rates. Smith BK, et al. Biochem J, 2012 Nov 15. PMID 22928974, Free PMC Article
  4. [Effect of pregnancy rats supplemented with docosahexaenoic acid on carnitine palmitoyl transferase-I gene expression in offspring]. Gong Q, et al. Wei Sheng Yan Jiu, 2009 Nov. PMID 20047222
  5. Evidence of a malonyl-CoA-insensitive carnitine palmitoyltransferase I activity in red skeletal muscle. Kim JY, et al. Am J Physiol Endocrinol Metab, 2002 May. PMID 11934665

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In summary, our results show that oxfenicine-induced inhibition of CPT-1b markedly affects WAT metabolism, leading to reduced adiposity through a mechanism that involves reduced lipogenesis in the SC Ing and Epid fat depots of rats.
    Title: Antilipolytic and antilipogenic effects of the CPT-1b inhibitor oxfenicine in the white adipose tissue of rats.
  2. CPT1B was significantly over-expressed in the amygdala and in the blood of stressed rats compared with non-stressed controls.
    Title: Mitochondria-focused gene expression profile reveals common pathways and CPT1B dysregulation in both rodent stress model and human subjects with PTSD.
  3. Increased fat accumulation characterizing obesity may be caused by impaired oxidative capacity due to decreased carnitine palmitoyltransferase 1b levels in the white adipose tissue.
    Title: Impaired oxidative capacity due to decreased CPT1b levels as a contributing factor to fat accumulation in obesity.
  4. The ratio of [P-CoA]/[M-CoA] is critical for regulating CPT-I activity & may partially rectify the in vivo disconnect between M-CoA content & CPT-I flux within the context of exercise & Type 2 diabetes.
    Title: Identification of a novel malonyl-CoA IC(50) for CPT-I: implications for predicting in vivo fatty acid oxidation rates.
  5. The protein expressions of CPT-I and PPARdelta decreased in excessive fatigue rats.
    Title: [Effects of fatigue and restraint stress on the expression of carnitine palmitoyltransferase-I and 5-hydroxytryptamine receptors in aorta of rats].
  6. Supplementation with docosahexaenoic acid during pregnancy could increase carnitine palmitoyl transferase-I gene expression in offspring.
    Title: [Effect of pregnancy rats supplemented with docosahexaenoic acid on carnitine palmitoyl transferase-I gene expression in offspring].
  7. Carnitine palmitoyl transferase 1 had a 47% decrease in untreated diabetic rats, which was normalized by insulin
    Title: Increased carnitine palmitoyl transferase 1 expression and decreased sterol regulatory element-binding protein 1c expression are associated with reduced intramuscular triglyceride accumulation after insulin therapy in high-fat-diet and streptozotocin-induced diabetic rats.
  8. a novel region in the first exon/intron of the CPT-Ibeta gene acts as a non-classical transcriptional enhancer
    Title: A region in the first exon/intron of rat carnitine palmitoyltransferase Ibeta is involved in enhancement of basal transcription.
  9. Genetic analysis, comparison, and tissue distribution of CPT1b
    Title: Structural and functional genomics of the CPT1B gene for muscle-type carnitine palmitoyltransferase I in mammals.
  10. muscle CPTI has high malonyl-CoA sensitivity
    Title: A single amino acid change (substitution of the conserved Glu-590 with alanine) in the C-terminal domain of rat liver carnitine palmitoyltransferase I increases its malonyl-CoA sensitivity close to that observed with the muscle isoform of the enzyme.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC93637

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables carnitine O-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carnitine O-palmitoyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables carnitine O-palmitoyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables carnitine O-palmitoyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in carnitine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in carnitine metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in fatty acid beta-oxidation IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in long-chain fatty acid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-chain fatty acid transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to blue light ISO
Inferred from Sequence Orthology
more info
  
involved_in response to blue light ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
carnitine O-palmitoyltransferase 1, muscle isoform
Names
CPT I
CPT-Ibeta 1
CPT-Ibeta 3
CPT1-M
CPTI-M
Carnitine palmitoyltransferase 1, muscle
carnitine palmitoyltransferase 1b, muscle
carnitine palmitoyltransferase I-like protein
carnitine palmitoyltransferase Ibeta 1
carnitine palmitoyltransferase Ibeta 2
carnitine palmitoyltransferase Ibeta 3
NP_037332.2
XP_006242242.1
XP_038934430.1
XP_063119136.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013200.2 → NP_037332.2  carnitine O-palmitoyltransferase 1, muscle isoform

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    Q63704
    UniProtKB/TrEMBL
    A6K7M6, O70253
    Related
    ENSRNOP00000013985.2, ENSRNOT00000013985.4
    Conserved Domains (2) summary
    pfam00755
    Location:173 → 761
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
    pfam16484
    Location:1 → 47
    CPT_N; Carnitine O-palmitoyltransferase N-terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    122370974..122380473 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063263066.1 → XP_063119136.1  carnitine O-palmitoyltransferase 1, muscle isoform isoform X2

    UniProtKB/Swiss-Prot
    Q63704
    UniProtKB/TrEMBL
    A6K7M6

  2. XM_006242180.5 → XP_006242242.1  carnitine O-palmitoyltransferase 1, muscle isoform isoform X1

    UniProtKB/TrEMBL
    O70253
    Conserved Domains (2) summary
    pfam00755
    Location:173 → 764
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
    pfam16484
    Location:1 → 47
    CPT_N; Carnitine O-palmitoyltransferase N-terminus

  3. XM_039078502.1 → XP_038934430.1  carnitine O-palmitoyltransferase 1, muscle isoform isoform X1

    UniProtKB/TrEMBL
    O70253
    Conserved Domains (2) summary
    pfam00755
    Location:173 → 764
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
    pfam16484
    Location:1 → 47
    CPT_N; Carnitine O-palmitoyltransferase N-terminus
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q63704.1 GenPept UniProtKB/Swiss-Prot:Q63704

Gene LinkOut

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