Dnm2 dynamin 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dnm2provided by RGD
Official Full Name: dynamin 2provided by RGD
Primary source: RGD:2513
See related: Ensembl:ENSRNOG00000007649 AllianceGenome:RGD:2513
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: DYIIAAB
Summary: Enables several functions, including D2 dopamine receptor binding activity; enzyme binding activity; and protein domain specific binding activity. Involved in several processes, including positive regulation of transport; regulation of plasma membrane bounded cell projection assembly; and regulation of signal transduction. Located in several cellular components, including Golgi apparatus; cytoplasmic vesicle; and ruffle membrane. Part of protein-containing complex. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Colocalizes with growth cone. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate B; centronuclear myopathy 1; and lethal congenital contracture syndrome. Orthologous to human DNM2 (dynamin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 219.3), Thymus (RPKM 204.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q13

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (28254344..28336297)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (19978313..20060162)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (22458869..22540649)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regulation of fenestra formation via actin-dynamin2 interaction in rat pituitary endothelial cells.
Title: Regulation of fenestra formation via actin-dynamin2 interaction in rat pituitary endothelial cells.
Asymmetric distribution of dynamin-2 and beta-catenin relative to tight junction spikes in alveolar epithelial cells.
Title: Asymmetric distribution of dynamin-2 and β-catenin relative to tight junction spikes in alveolar epithelial cells.
Study is the first to show the association of dynamin Charcot-Marie-Tooth disease mutations with aberrant actin dynamics and lamellipodia, which may contribute to defective endocytosis and myelination in Schwann cells in Charcot-Marie-Tooth disease.
Title: Expression of a dynamin 2 mutant associated with Charcot-Marie-Tooth disease leads to aberrant actin dynamics and lamellipodia formation.
Reduction in dynamin-2 is implicated in ischaemic cardiac arrhythmias.
Title: Reduction in dynamin-2 is implicated in ischaemic cardiac arrhythmias.
dynamin2 orchestrates the global actin cytoskeleton
Title: Dynamin2 organizes lamellipodial actin networks to orchestrate lamellar actomyosin.
Disruption of the DNM2-dependent retrograde trafficking of NHE1 contributes to cardiomyocyte apoptosis.
Title: Aberrant dynamin 2-dependent Na(+) /H(+) exchanger-1 trafficking contributes to cardiomyocyte apoptosis.
dynamin isoforms select appropriate vesicle reuse pathways associated with specific neuronal firing patterns
Title: Dynamin isoforms decode action potential firing for synaptic vesicle recycling.
Data indicate that dynamin-2, clathrin, and lipid rafts mediate Na/K/2Cl cotransporter NKCC2 endocytosis and maintain steady-state apical surface NKCC2 in the renal thick ascending limb (THAL).
Title: Dynamin2, clathrin, and lipid rafts mediate endocytosis of the apical Na/K/2Cl cotransporter NKCC2 in thick ascending limbs.
This study suggested that myelination is strictly dependent on Dnm2 and clathrin-mediated endocytosis function.
Title: Dynamin 2 mutations in Charcot-Marie-Tooth neuropathy highlight the importance of clathrin-mediated endocytosis in myelination.
ITSN-1s, via its SH3A domain has the unique ability to regulate dyn2 assembly-disassembly and function during endocytosis
Title: Regulation of dynamin-2 assembly-disassembly and function through the SH3A domain of intersectin-1s.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH127437 (e-PCR)
- UniSTS:210747

RH94664 (e-PCR)
- UniSTS:119911

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables D2 dopamine receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	TAS Traceable Author Statement more info	PubMed
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables GTPase activity	TAS Traceable Author Statement more info	PubMed
enables SH3 domain binding	IEA Inferred from Electronic Annotation more info
enables SH3 domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables SH3 domain binding	ISO Inferred from Sequence Orthology more info
enables WW domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables nitric-oxide synthase binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol 3-kinase regulatory subunit binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-4,5-bisphosphate binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-4,5-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-4,5-bisphosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor internalization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Golgi to plasma membrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament bundle organization	IEA Inferred from Electronic Annotation more info
involved_in actin filament bundle organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament bundle organization	ISO Inferred from Sequence Orthology more info
involved_in actin filament bundle organization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within aorta development	ISO Inferred from Sequence Orthology more info
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in autophagy	ISO Inferred from Sequence Orthology more info
involved_in autophagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to X-ray	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to carbon monoxide	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to dopamine	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to nitric oxide	IEP Inferred from Expression Pattern more info	PubMed
involved_in centrosome cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within coronary vasculature development	ISO Inferred from Sequence Orthology more info
involved_in endocytosis	ISO Inferred from Sequence Orthology more info
involved_in endocytosis	TAS Traceable Author Statement more info	PubMed
involved_in macropinocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane tubulation	IEA Inferred from Electronic Annotation more info
involved_in membrane tubulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane tubulation	ISO Inferred from Sequence Orthology more info
involved_in membrane tubulation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of membrane tubulation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of membrane tubulation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of non-motile cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phagocytosis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of clathrin-dependent endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of lamellipodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of nitric oxide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of substrate adhesion-dependent cell spreading	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein polymerization	IEA Inferred from Electronic Annotation more info
involved_in protein polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein polymerization	ISO Inferred from Sequence Orthology more info
involved_in protein polymerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in receptor internalization	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor internalization	IEA Inferred from Electronic Annotation more info
involved_in receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in receptor-mediated endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in receptor-mediated endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of Golgi organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of Rac protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to cocaine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to light stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in stress fiber assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle budding from presynaptic endocytic zone membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle endocytosis	ISO Inferred from Sequence Orthology more info
involved_in transferrin transport	IEA Inferred from Electronic Annotation more info
involved_in transferrin transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ventricular septum development	ISO Inferred from Sequence Orthology more info
involved_in vesicle scission	IEA Inferred from Electronic Annotation more info
involved_in vesicle scission	ISO Inferred from Sequence Orthology more info
involved_in vesicle scission	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IDA Inferred from Direct Assay more info	PubMed
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in centriole	IEA Inferred from Electronic Annotation more info
located_in centriole	ISO Inferred from Sequence Orthology more info
located_in centriole	ISS Inferred from Sequence or Structural Similarity more info
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in clathrin-coated endocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in clathrin-coated pit	IDA Inferred from Direct Assay more info	PubMed
located_in clathrin-coated pit	ISO Inferred from Sequence Orthology more info
located_in clathrin-coated vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in clathrin-coated vesicle	IEA Inferred from Electronic Annotation more info
located_in clathrin-coated vesicle	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in meiotic spindle	ISO Inferred from Sequence Orthology more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in microtubule	ISO Inferred from Sequence Orthology more info
located_in microtubule	ISS Inferred from Sequence or Structural Similarity more info
located_in midbody	IEA Inferred from Electronic Annotation more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in phagocytic cup	IDA Inferred from Direct Assay more info	PubMed
located_in phagocytic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in photoreceptor inner segment	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in podosome	IEA Inferred from Electronic Annotation more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density, intracellular component	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density, intracellular component	IMP Inferred from Mutant Phenotype more info	PubMed
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in presynapse	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
located_in recycling endosome	IEA Inferred from Electronic Annotation more info
located_in recycling endosome	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in ruffle membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed
located_in uropod	IEA Inferred from Electronic Annotation more info
located_in uropod	ISO Inferred from Sequence Orthology more info
located_in uropod	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: dynamin-2

NP_037331.1

EC 3.6.5.5

XP_006242670.1

EC 3.6.5.5

XP_006242672.1

EC 3.6.5.5

XP_006242673.1

EC 3.6.5.5

XP_006242674.1

EC 3.6.5.5

XP_006242675.1

EC 3.6.5.5

XP_006242676.1

EC 3.6.5.5

XP_038936844.1

EC 3.6.5.5

XP_038936845.1

EC 3.6.5.5

XP_038936846.1

EC 3.6.5.5

XP_038936848.1

EC 3.6.5.5

XP_038936849.1

EC 3.6.5.5

XP_063121054.1

EC 3.6.5.5

XP_063121055.1

EC 3.6.5.5

XP_063121056.1

EC 3.6.5.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013199.2 → NP_037331.1 dynamin-2

See identical proteins and their annotated locations for NP_037331.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

P39052

UniProtKB/TrEMBL

A0A8L2Q4Y6

Related

ENSRNOP00000077232.1, ENSRNOT00000112167.1

Conserved Domains (5) summary

smart00053
Location:6 → 245

DYNc; Dynamin, GTPase

PHA03247
Location:737 → 868

PHA03247; large tegument protein UL36; Provisional

cd01256
Location:520 → 629

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:216 → 502

Dynamin_M; Dynamin central region

pfam02212
Location:651 → 739

GED; Dynamin GTPase effector domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

28254344..28336297

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006242614.5 → XP_006242676.1 dynamin-2 isoform X8

UniProtKB/TrEMBL

A0A0A0MY48, A0A8L2Q4Y6

Related

ENSRNOP00000059940.3

Conserved Domains (5) summary

smart00053
Location:6 → 245

DYNc; Dynamin, GTPase

PHA03247
Location:737 → 836

PHA03247; large tegument protein UL36; Provisional

cd01256
Location:520 → 629

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:216 → 502

Dynamin_M; Dynamin central region

pfam02212
Location:651 → 739

GED; Dynamin GTPase effector domain
XM_039080918.2 → XP_038936846.1 dynamin-2 isoform X10

UniProtKB/TrEMBL

A0A8L2Q4Y6, A6JNS2

Conserved Domains (5) summary

smart00053
Location:6 → 245

DYNc; Dynamin, GTPase

PHA03247
Location:733 → 832

PHA03247; large tegument protein UL36; Provisional

cd01256
Location:514 → 625

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:216 → 502

Dynamin_M; Dynamin central region

pfam02212
Location:647 → 735

GED; Dynamin GTPase effector domain
XM_039080917.2 → XP_038936845.1 dynamin-2 isoform X9

UniProtKB/TrEMBL

A0A8L2Q4Y6

Conserved Domains (5) summary

smart00053
Location:6 → 245

DYNc; Dynamin, GTPase

PHA03247
Location:737 → 836

PHA03247; large tegument protein UL36; Provisional

cd01256
Location:520 → 629

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:216 → 502

Dynamin_M; Dynamin central region

pfam02212
Location:651 → 739

GED; Dynamin GTPase effector domain
XM_039080920.2 → XP_038936848.1 dynamin-2 isoform X11

UniProtKB/TrEMBL

A0A8L2Q4Y6

Conserved Domains (5) summary

smart00053
Location:6 → 245

DYNc; Dynamin, GTPase

PHA03247
Location:733 → 832

PHA03247; large tegument protein UL36; Provisional

cd01256
Location:514 → 625

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:216 → 502

Dynamin_M; Dynamin central region

pfam02212
Location:647 → 735

GED; Dynamin GTPase effector domain
XM_006242611.5 → XP_006242673.1 dynamin-2 isoform X2

UniProtKB/TrEMBL

A0A8I6ADL1, A0A8L2Q4Y6

Related

ENSRNOP00000089994.1

Conserved Domains (5) summary

smart00053
Location:6 → 245

DYNc; Dynamin, GTPase

PHA03247
Location:737 → 867

PHA03247; large tegument protein UL36; Provisional

cd01256
Location:520 → 629

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:216 → 502

Dynamin_M; Dynamin central region

pfam02212
Location:651 → 739

GED; Dynamin GTPase effector domain
XM_006242613.5 → XP_006242675.1 dynamin-2 isoform X4

See identical proteins and their annotated locations for XP_006242675.1

UniProtKB/TrEMBL

A0A8L2Q4Y6, A6JNS3

Conserved Domains (5) summary

smart00053
Location:6 → 245

DYNc; Dynamin, GTPase

PHA03247
Location:733 → 864

PHA03247; large tegument protein UL36; Provisional

cd01256
Location:514 → 625

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:216 → 502

Dynamin_M; Dynamin central region

pfam02212
Location:647 → 735

GED; Dynamin GTPase effector domain
XM_063264984.1 → XP_063121054.1 dynamin-2 isoform X6

UniProtKB/TrEMBL

A0A0A0MY49
XM_006242608.5 → XP_006242670.1 dynamin-2 isoform X1

UniProtKB/TrEMBL

A0A8L2Q4Y6

Conserved Domains (5) summary

smart00053
Location:6 → 245

DYNc; Dynamin, GTPase

PHA03247
Location:737 → 868

PHA03247; large tegument protein UL36; Provisional

cd01256
Location:520 → 629

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:216 → 502

Dynamin_M; Dynamin central region

pfam02212
Location:651 → 739

GED; Dynamin GTPase effector domain
XM_006242610.5 → XP_006242672.1 dynamin-2 isoform X3

UniProtKB/TrEMBL

A0A8I6A1C6, A0A8L2Q4Y6

Related

ENSRNOP00000086498.1

Conserved Domains (5) summary

smart00053
Location:6 → 245

DYNc; Dynamin, GTPase

PHA03247
Location:737 → 867

PHA03247; large tegument protein UL36; Provisional

cd01256
Location:520 → 629

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:216 → 502

Dynamin_M; Dynamin central region

pfam02212
Location:651 → 739

GED; Dynamin GTPase effector domain
XM_006242612.5 → XP_006242674.1 dynamin-2 isoform X5

UniProtKB/TrEMBL

A0A8L2Q4Y6

Conserved Domains (5) summary

smart00053
Location:6 → 245

DYNc; Dynamin, GTPase

PHA03247
Location:733 → 864

PHA03247; large tegument protein UL36; Provisional

cd01256
Location:514 → 625

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:216 → 502

Dynamin_M; Dynamin central region

pfam02212
Location:647 → 735

GED; Dynamin GTPase effector domain
XM_039080916.2 → XP_038936844.1 dynamin-2 isoform X7

UniProtKB/TrEMBL

A0A8L2Q4Y6

Conserved Domains (5) summary

smart00053
Location:6 → 245

DYNc; Dynamin, GTPase

PHA03247
Location:733 → 863

PHA03247; large tegument protein UL36; Provisional

cd01256
Location:514 → 625

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:216 → 502

Dynamin_M; Dynamin central region

pfam02212
Location:647 → 735

GED; Dynamin GTPase effector domain
XM_063264985.1 → XP_063121055.1 dynamin-2 isoform X12
XM_039080921.2 → XP_038936849.1 dynamin-2 isoform X14

Conserved Domains (2) summary

smart00053
Location:6 → 245

DYNc; Dynamin, GTPase

pfam01031
Location:216 → 498

Dynamin_M; Dynamin central region
XM_063264986.1 → XP_063121056.1 dynamin-2 isoform X13