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Maob monoamine oxidase B [ Rattus norvegicus (Norway rat) ]

Gene ID: 25750, updated on 5-Mar-2024

Summary

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Official Symbol
Maobprovided by RGD
Official Full Name
monoamine oxidase Bprovided by RGD
Primary source
RGD:3041
See related
Ensembl:ENSRNOG00000029778 AllianceGenome:RGD:3041
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables flavin adenine dinucleotide binding activity; identical protein binding activity; and primary amine oxidase activity. Involved in several processes, including negative regulation of serotonin secretion; positive regulation of dopamine metabolic process; and response to corticosterone. Located in mitochondrial outer membrane. Biomarker of Parkinson's disease and cholestasis. Human ortholog(s) of this gene implicated in Alzheimer's disease and Parkinson's disease. Orthologous to human MAOB (monoamine oxidase B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 548.4), Lung (RPKM 237.7) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
Xq11
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (8490405..8594065)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (5907327..6010996)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (6430694..6533520)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene basic leucine zipper nuclear factor 1, pseudogene 1 Neighboring gene norrin cystine knot growth factor NDP Neighboring gene monoamine oxidase A Neighboring gene AE binding protein 2, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Dopamine induces Ca2+ signaling in astrocytes through reactive oxygen species generated by monoamine oxidase. Vaarmann A, et al. J Biol Chem, 2010 Aug 6. PMID 20547771, Free PMC Article
  2. Ethanol increases TIEG2-MAO B cell death cascade in the prefrontal cortex of ethanol-preferring rats. Ou XM, et al. Neurotox Res, 2011 May. PMID 20204567, Free PMC Article
  3. A novel role for glyceraldehyde-3-phosphate dehydrogenase and monoamine oxidase B cascade in ethanol-induced cellular damage. Ou XM, et al. Biol Psychiatry, 2010 May 1. PMID 20022592, Free PMC Article
  4. Berberine and total base from rhizoma coptis chinensis attenuate brain injury in an aluminum-induced rat model of neurodegenerative disease. Zhang J, et al. Saudi Med J, 2009 Jun. PMID 19526156
  5. Reduced activity of monoamine oxidase in the rat brain following repeated nandrolone decanoate administration. Birgner C, et al. Brain Res, 2008 Jul 11. PMID 18539264

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Monoamine oxidase is a source of cardiac oxidative stress in obese rats: the beneficial role of metformin.
    Title: Monoamine oxidase is a source of cardiac oxidative stress in obese rats: the beneficial role of metformin.
  2. Redefining differential roles of MAO-A in dopamine degradation and MAO-B in tonic GABA synthesis.
    Title: Redefining differential roles of MAO-A in dopamine degradation and MAO-B in tonic GABA synthesis.
  3. Monoamine Oxidase-B Inhibition Facilitates alpha-Synuclein Secretion In Vitro and Delays Its Aggregation in rAAV-Based Rat Models of Parkinson's Disease.
    Title: Monoamine Oxidase-B Inhibition Facilitates α-Synuclein Secretion In Vitro and Delays Its Aggregation in rAAV-Based Rat Models of Parkinson's Disease.
  4. Benzylamine and serotonin oxidation were catalyzed by MAO-B and MAO-A, respectively, to aldehydes. These were derivatized with DNPH, and the corresponding quinones were further formed by adding NaOH. These DNPH derivatives with large conjugated structures were directly measured spectrophotometrically at 465 nm and 425 nm
    Title: A spectrophotometric assay for monoamine oxidase activity with 2, 4-dinitrophenylhydrazine as a derivatized reagent.
  5. Monoamine oxidase B is increased in prefrontal cortex following ethanol administration.
    Title: Ethanol increases TIEG2-MAO B cell death cascade in the prefrontal cortex of ethanol-preferring rats.
  6. investigation of topological orientation of MAO-B (and MAO-A) in liver mitochondrial membranes
    Title: Topological probes of monoamine oxidases A and B in rat liver mitochondria: inhibition by TEMPO-substituted pargyline analogues and inactivation by proteolysis.
  7. Dopamine induces Ca2+ signaling in astrocytes through reactive oxygen species generated by monoamine oxidase
    Title: Dopamine induces Ca2+ signaling in astrocytes through reactive oxygen species generated by monoamine oxidase.
  8. significant effects of hormone replacement and gonadectomy on catechol-O-methyltransferase and monoamine oxidase isoforms in both striatum and cortex
    Title: Gonadectomy and hormone replacement exert region- and enzyme isoform-specific effects on monoamine oxidase and catechol-O-methyltransferase activity in prefrontal cortex and neostriatum of adult male rats.
  9. These results suggest that LPS induces chronic wounds via elevated MAO/B-mediated increases in H(2)O(2) and TNF-alpha activity by epithelial cells and is further associated with more distant effects on systemic oxidative stress and alveolar bone loss.
    Title: Lipopolysaccharide-induced epithelial monoamine oxidase mediates alveolar bone loss in a rat chronic wound model.
  10. localization of monoamine oxidase type B in liver; no MAOB was found in endothelial cells, hepatic stellate cells, or Kupffer cells; MAOB was localized to the mitochondrial outer membrane of hepatocytes
    Title: Immunocytochemical localization of monoamine oxidase type B in rat liver.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables aliphatic amine oxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables flavin adenine dinucleotide binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables monoamine oxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables monoamine oxidase activity ISO
Inferred from Sequence Orthology
more info
  
enables primary amine oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables primary amine oxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables primary amine oxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables primary amine oxidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of serotonin secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phenylethylamine catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of dopamine metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to aluminum ion IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to corticosterone IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to ethanol IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to selenium ion IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to steroid hormone IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to toxic substance IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in substantia nigra development ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
amine oxidase [flavin-containing] B
Names
MAO-B
monoamine oxidase type B
NP_037330.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013198.1 → NP_037330.1  amine oxidase [flavin-containing] B

    See identical proteins and their annotated locations for NP_037330.1

    Status: PROVISIONAL

    Source sequence(s)
    M23601
    UniProtKB/Swiss-Prot
    P19643, Q5EBB5
    UniProtKB/TrEMBL
    A6JZX1
    Related
    ENSRNOP00000043466.4, ENSRNOT00000044009.6
    Conserved Domains (2) summary
    COG1231
    Location:5 → 451
    YobN; Monoamine oxidase [Amino acid transport and metabolism]
    pfam13450
    Location:9 → 75
    NAD_binding_8; NAD(P)-binding Rossmann-like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    8490405..8594065
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P19643.3 GenPept UniProtKB/Swiss-Prot:P19643

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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