Gnaz G protein subunit alpha z [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gnazprovided by RGD
Official Full Name: G protein subunit alpha zprovided by RGD
Primary source: RGD:2717
See related: Ensembl:ENSRNOG00000001313 AllianceGenome:RGD:2717
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: GXA; Hg1h
Summary: Enables G protein-coupled serotonin receptor binding activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway. Located in cytosol and plasma membrane. Orthologous to human GNAZ (G protein subunit alpha z). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 67.9), Spleen (RPKM 11.8) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (13642853..13693616, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (13643473..13694240, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (14593072..14644020, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Central Galphaz (inhibitory) and Galphaq (stimulatory) activity differentially modulates AVP release to control the pattern of diuresis to intracerebroventricular nociceptin.
Title: Central G-alpha subunit protein-mediated control of cardiovascular function, urine output, and vasopressin secretion in conscious Sprague-Dawley rats.
endothelin-1 in picomolar concentrations can interrupt prolactin release for several hours downstream of spontaneous and high K+-stimulated voltage-gated Ca2+ influx. This action occurred through the Gz signaling pathway.
Title: Endothelin-induced, long lasting, and Ca2+ influx-independent blockade of intrinsic secretion in pituitary cells by Gz subunits.
An endogenous receptor-mediated signaling process in pancreatic beta-cells is dependent on G alpha(z) function.
Title: A role for G(z) in pancreatic islet beta-cell biology.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled serotonin receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables G-protein beta/gamma-subunit complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	TAS Traceable Author Statement more info	PubMed
enables adenylate cyclase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled serotonin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of insulin secretion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell body	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
part_of heterotrimeric G-protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of heterotrimeric G-protein complex	TAS Traceable Author Statement more info	PubMed
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: guanine nucleotide-binding protein G(z) subunit alpha

Names: Guanine nucleotide binding protein alpha; g(x) alpha chain; guanine nucleotide binding protein (G protein), alpha z polypeptide; guanine nucleotide binding protein, alpha z polypeptide; guanine nucleotide binding protein, alpha z subunit; gz-alpha; heterotrimeric guanine nucleotide-binding protein 1h

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013189.2 → NP_037321.1 guanine nucleotide-binding protein G(z) subunit alpha

See identical proteins and their annotated locations for NP_037321.1

Status: PROVISIONAL

Source sequence(s)

J03773

UniProtKB/Swiss-Prot

P19627

UniProtKB/TrEMBL

A6JKM2

Related

ENSRNOP00000001779.2, ENSRNOT00000001779.5

Conserved Domains (1) summary

cd00066
Location:34 → 349

G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

13642853..13693616 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008772867.3 → XP_008771089.1 guanine nucleotide-binding protein G(z) subunit alpha isoform X1

See identical proteins and their annotated locations for XP_008771089.1

UniProtKB/Swiss-Prot

P19627

UniProtKB/TrEMBL

A6JKM2

Conserved Domains (1) summary

cd00066
Location:34 → 349

G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)