Mc5r melanocortin 5 receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mc5rprovided by RGD
Official Full Name: melanocortin 5 receptorprovided by RGD
Primary source: RGD:3058
See related: Ensembl:ENSRNOG00000016685 AllianceGenome:RGD:3058
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables hormone binding activity and melanocortin receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and regulation of metabolic process. Predicted to be integral component of membrane. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human MC5R (melanocortin 5 receptor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: 18q12.1

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (64185013..64190054)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (61915188..61920229)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (64113659..64118700)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Compared with low-activity rats, high-activity rats show enhanced mRNA expression of MCRs in the brain, specifically of MC3R in the paraventricular nucleus, and MC4R and MC5R in the perifornical lateral hypothalamus.
Title: Region-specific differences in brain melanocortin receptors in rats of the lean phenotype.
Mc5 receptor expression is localized to the ganglion cell and inner nuclear layers in adult retina and superior colliculus and is decreased after optic nerve transection.
Title: Proopiomelanocortin and melanocortin receptors in the adult rat retino-tectal system and their regulation after optic nerve transection.
Expression levels of melanocortin 3 receptor (MC3R) and melanocortin 5 receptor (MC5R) were not significantly affected by high dietary salt intake in either WKY or SP-SHR tissues
Title: Prevalence of melanocortin system transcripts in rat salt homeostasis endocrine tissues.

Submit: New GeneRIF Correction

General gene information

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Markers

RH142200 (e-PCR)
- UniSTS:231450

RH94550 (e-PCR)
- UniSTS:119798

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables hormone binding	IDA Inferred from Direct Assay more info	PubMed
enables hormone binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables melanocortin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables melanocortin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables melanocortin receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: melanocortin receptor 5

Names: MC5-R

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013182.3 → NP_037314.1 melanocortin receptor 5

See identical proteins and their annotated locations for NP_037314.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000018

UniProtKB/Swiss-Prot

P35345

UniProtKB/TrEMBL

A6IXX6

Related

ENSRNOP00000022364.3, ENSRNOT00000022364.5

Conserved Domains (2) summary

pfam00001
Location:53 → 295

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:43 → 311

7tm_4; Olfactory receptor