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Itgb7 integrin subunit beta 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25713, updated on 13-Apr-2024

Summary

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Official Symbol
Itgb7provided by RGD
Official Full Name
integrin subunit beta 7provided by RGD
Primary source
RGD:2929
See related
Ensembl:ENSRNOG00000012208 AllianceGenome:RGD:2929
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable integrin binding activity. Predicted to be involved in several processes, including integrin-mediated signaling pathway; leukocyte tethering or rolling; and substrate adhesion-dependent cell spreading. Predicted to act upstream of or within T cell migration. Predicted to be part of integrin alpha4-beta7 complex. Predicted to be active in cell surface and focal adhesion. Orthologous to human ITGB7 (integrin subunit beta 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 121.1), Spleen (RPKM 79.2) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
7q36
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (135225962..135243522, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (133347927..133364955, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (143820236..143837802, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene sterol O-acyltransferase 2 Neighboring gene cysteine sulfinic acid decarboxylase Neighboring gene zinc finger protein 740 Neighboring gene uncharacterized LOC134479582 Neighboring gene retinoic acid receptor, gamma Neighboring gene uncharacterized LOC134479581

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Integrin αEβ7 is involved in the intestinal barrier injury of sepsis. Sun JK, et al. Aging (Albany NY), 2022 Jan 18. PMID 35042191, Free PMC Article
  2. Structure-function analysis of the integrin beta 7 subunit: identification of domains involved in adhesion to MAdCAM-1. Tidswell M, et al. J Immunol, 1997 Aug 1. PMID 9233649
  3. Disruption of disulfide restriction at integrin knees induces activation and ligand-independent signaling of α₄β₇. Zhang K, et al. J Cell Sci, 2013 Nov 1. PMID 23986478
  4. Functional involvement of P-selectin and MAdCAM-1 in the recruitment of alpha4beta7-integrin-expressing monocyte-like cells to the pregnant mouse uterus. Fernekorn U, et al. Eur J Immunol, 2004 Dec. PMID 15484189
  5. GPR15-mediated homing controls immune homeostasis in the large intestine mucosa. Kim SV, et al. Science, 2013 Jun 21. PMID 23661644, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Integrin alphaEbeta7 is involved in the intestinal barrier injury of sepsis.
    Title: Integrin αEβ7 is involved in the intestinal barrier injury of sepsis.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
  
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within T cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in cell adhesion mediated by integrin IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in cell-matrix adhesion involved in ameboidal cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in leukocyte migration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within leukocyte migration ISO
Inferred from Sequence Orthology
more info
  
involved_in leukocyte tethering or rolling ISO
Inferred from Sequence Orthology
more info
  
involved_in receptor clustering ISO
Inferred from Sequence Orthology
more info
  
involved_in substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of integrin alpha4-beta7 complex ISO
Inferred from Sequence Orthology
more info
  
part_of integrin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
integrin beta-7
Names
integrin, beta 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013171.1 → NP_037303.1  integrin beta-7 precursor

    See identical proteins and their annotated locations for NP_037303.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A6KCT9, G3V7M2
    Conserved Domains (5) summary
    pfam00362
    Location:50 → 477
    Integrin_beta; Integrin, beta chain
    pfam07965
    Location:646 → 717
    Integrin_B_tail; Integrin beta tail domain
    pfam07974
    Location:608 → 636
    EGF_2; EGF-like domain
    pfam08725
    Location:750 → 791
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    pfam12785
    Location:538 → 646
    VESA1_N; Variant erythrocyte surface antigen-1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    135225962..135243522 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006242383.5 → XP_006242445.1  integrin beta-7 isoform X1

    See identical proteins and their annotated locations for XP_006242445.1

    UniProtKB/TrEMBL
    A6KCT9, G3V7M2
    Related
    ENSRNOP00000016642.4
    Conserved Domains (5) summary
    pfam00362
    Location:50 → 477
    Integrin_beta; Integrin, beta chain
    pfam07965
    Location:646 → 717
    Integrin_B_tail; Integrin beta tail domain
    pfam07974
    Location:608 → 636
    EGF_2; EGF-like domain
    pfam08725
    Location:750 → 791
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    pfam12785
    Location:538 → 646
    VESA1_N; Variant erythrocyte surface antigen-1
Nucleotide Protein Strain
Heading Accession and Version

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