Il2ra interleukin 2 receptor subunit alpha [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Il2raprovided by RGD
Official Full Name: interleukin 2 receptor subunit alphaprovided by RGD
Primary source: RGD:2895
See related: Ensembl:ENSRNOG00000047647 AllianceGenome:RGD:2895
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: IL2RAC
Summary: Enables interleukin-2 receptor activity. Involved in inflammatory response to antigenic stimulus; positive regulation of T cell differentiation; and positive regulation of T cell proliferation. Located in cell surface. Used to study Korean hemorrhagic fever; asthma; and diabetes mellitus. Human ortholog(s) of this gene implicated in immunodeficiency 41; lymphopenia; multiple sclerosis; type 1 diabetes mellitus; and type 1 diabetes mellitus 10. Orthologous to human IL2RA (interleukin 2 receptor subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 88.7), Spleen (RPKM 13.6) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 17q12.2

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (71759802..71808475, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (66849974..66898665, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (70500672..70547929, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Adoptive transfusion of CD4+CD25+ (Interleukin-2 Receptor alpha) Regulatory T Cells into Experimental Autoimmune Neuritis model rats has significant therapeutic effects.
Title: Therapeutic Effect of CD4+CD25+ Regulatory T Cells Amplified In Vitro on Experimental Autoimmune Neuritis in Rats.
Deletion of antigen-specific T cells by apoptosis and active suppression mediated by CD4(+)CD25(+) T-regulatory cells has an important role in the induction of antigen specific immune tolerance
Title: Antigen-specific tolerance inhibits autoimmune uveitis in pre-sensitized animals by deletion and CD4+CD25+ T-regulatory cells.

Submit: New GeneRIF Correction

General gene information

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Markers

fb22g09.x1 (e-PCR)
- UniSTS:203070

RH143008 (e-PCR)
- UniSTS:232255

RH94535 (e-PCR)
- UniSTS:119783

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables interleukin-2 binding	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-2 binding	ISO Inferred from Sequence Orthology more info
enables interleukin-2 receptor activity	IPI Inferred from Physical Interaction more info	PubMed
contributes_to interleukin-2 receptor activity	ISO Inferred from Sequence Orthology more info
enables interleukin-2 receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Notch signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within T cell homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of activated T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within activation-induced cell death of T cells	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response to antigenic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in interleukin-2-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of lymphocyte proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of lymphocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of activated T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of CD4-positive, alpha-beta T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of T cell homeostatic proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of T cell tolerance induction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interleukin-2 receptor subunit alpha

Names: IL-2 receptor alpha subunit; IL-2 receptor subunit alpha; IL-2-RA; IL-2R subunit alpha; IL2-RA; interleukin 2 receptor, alpha chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013163.2 → NP_037295.1 interleukin-2 receptor subunit alpha precursor

See identical proteins and their annotated locations for NP_037295.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000017

UniProtKB/Swiss-Prot

P26897

UniProtKB/TrEMBL

A6JLS0

Related

ENSRNOP00000066383.1, ENSRNOT00000073144.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

71759802..71808475 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039095399.2 → XP_038951327.1 interleukin-2 receptor subunit alpha isoform X1

Conserved Domains (1) summary

cd00033
Location:20 → 80

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system