Ahr aryl hydrocarbon receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ahrprovided by RGD
Official Full Name: aryl hydrocarbon receptorprovided by RGD
Primary source: RGD:2074
See related: Ensembl:ENSRNOG00000004342 AllianceGenome:RGD:2074
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables nuclear receptor activity and toxic substance binding activity. Involved in several processes, including cellular response to organic cyclic compound; negative regulation of alkaline phosphatase activity; and regulation of cellular macromolecule biosynthetic process. Located in cytosol and nucleus. Human ortholog(s) of this gene implicated in retinitis pigmentosa 85. Orthologous to human AHR (aryl hydrocarbon receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 311.4), Liver (RPKM 218.9) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q16

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (57961423..57998901, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (52234089..52271568, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (54963990..55001806, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Comparison of moderate-intensity continuous training and high-intensity interval training effects on the Ido1-KYN-Ahr axis in the heart tissue of rats with occlusion of the left anterior descending artery.
Title: Comparison of moderate-intensity continuous training and high-intensity interval training effects on the Ido1-KYN-Ahr axis in the heart tissue of rats with occlusion of the left anterior descending artery.
Epithelial cell invasion by salmonella typhimurium induces modulation of genes controlled by aryl hydrocarbon receptor signaling and involved in extracellular matrix biogenesis.
Title: Epithelial cell invasion by salmonella typhimurium induces modulation of genes controlled by aryl hydrocarbon receptor signaling and involved in extracellular matrix biogenesis.
Involvement of the CYP1A1 inhibition-mediated activation of aryl hydrocarbon receptor in drug-induced hepatotoxicity.
Title: Involvement of the CYP1A1 inhibition-mediated activation of aryl hydrocarbon receptor in drug-induced hepatotoxicity.
Aryl hydrocarbon receptor is essential for the pathogenesis of pulmonary arterial hypertension.
Title: Aryl hydrocarbon receptor is essential for the pathogenesis of pulmonary arterial hypertension.
Betulin ameliorates 7,12-dimethylbenz(a)anthracene-induced rat mammary cancer by modulating MAPK and AhR/Nrf-2 signaling pathway.
Title: Betulin ameliorates 7,12-dimethylbenz(a)anthracene-induced rat mammary cancer by modulating MAPK and AhR/Nrf-2 signaling pathway.
Neuroprotective effect of 3,3'-Diindolylmethane against perinatal asphyxia involves inhibition of the AhR and NMDA signaling and hypermethylation of specific genes.
Title: Neuroprotective effect of 3,3'-Diindolylmethane against perinatal asphyxia involves inhibition of the AhR and NMDA signaling and hypermethylation of specific genes.
Aryl Hydrocarbon Receptor is Involved in the Proinflammatory Cytokine Response to Cadmium.
Title: Aryl Hydrocarbon Receptor is Involved in the Proinflammatory Cytokine Response to Cadmium.
Hydrogen alleviates lung injury induced by PM2.5 possibly through AhR-dependent mechanisms.
Title: Hydrogen ameliorates lung injury in a rat model of subacute exposure to concentrated ambient PM2.5 via Aryl hydrocarbon receptor.
Aryl hydrocarbon receptor signaling plays a role in gonadotropin synthesis during the developmental stage to acquire sexual dimorphism.
Title: The aryl hydrocarbon receptor is indispensable for dioxin-induced defects in sexually-dimorphic behaviors due to the reduction in fetal steroidogenesis of the pituitary-gonadal axis in rats.
AITC prevents DMBA-induced mammary carcinogenesis via inhibition of phase I and induction of phase II detoxification enzymes by modulating AhR/Nrf2 signaling pathway.
Title: Allyl isothiocyanate, a potent chemopreventive agent targets AhR/Nrf2 signaling pathway in chemically induced mammary carcinogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (51)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH140665 (e-PCR)
- UniSTS:222733

RH140680 (e-PCR)
- UniSTS:222748

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables E-box binding	ISO Inferred from Sequence Orthology more info
enables E-box binding	ISS Inferred from Sequence or Structural Similarity more info
enables Hsp90 protein binding	IEA Inferred from Electronic Annotation more info
enables Hsp90 protein binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables TBP-class protein binding	IEA Inferred from Electronic Annotation more info
enables TBP-class protein binding	ISO Inferred from Sequence Orthology more info
enables TFIID-class transcription factor complex binding	IEA Inferred from Electronic Annotation more info
enables TFIID-class transcription factor complex binding	ISO Inferred from Sequence Orthology more info
enables arachidonic acid omega-hydroxylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables aryl hydrocarbon receptor binding	ISO Inferred from Sequence Orthology more info
enables cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables nuclear receptor activity	IEA Inferred from Electronic Annotation more info
contributes_to nuclear receptor activity	ISO Inferred from Sequence Orthology more info
enables nuclear receptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-folding chaperone binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables toxic substance binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription cis-regulatory region binding	IBA Inferred from Biological aspect of Ancestor more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator binding	IEA Inferred from Electronic Annotation more info
enables transcription coactivator binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B cell homeostasis	ISO Inferred from Sequence Orthology more info
involved_in T cell homeostasis	ISO Inferred from Sequence Orthology more info
involved_in aflatoxin metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in apoptotic process	TAS Traceable Author Statement more info	PubMed
involved_in blood circulation	ISO Inferred from Sequence Orthology more info
involved_in blood vessel development	ISO Inferred from Sequence Orthology more info
involved_in blood vessel morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in blood vessel remodeling	ISO Inferred from Sequence Orthology more info
involved_in branching involved in blood vessel morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cAMP-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in cAMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in camera-type eye development	ISO Inferred from Sequence Orthology more info
involved_in cardiac left ventricle morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cell morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cellular response to 2,3,7,8-tetrachlorodibenzodioxine	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to 2,3,7,8-tetrachlorodibenzodioxine	IEA Inferred from Electronic Annotation more info
involved_in cellular response to 2,3,7,8-tetrachlorodibenzodioxine	ISO Inferred from Sequence Orthology more info
involved_in cellular response to 3-methylcholanthrene	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cAMP	IEA Inferred from Electronic Annotation more info
involved_in cellular response to cAMP	ISO Inferred from Sequence Orthology more info
involved_in cellular response to forskolin	IEA Inferred from Electronic Annotation more info
involved_in cellular response to forskolin	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucocorticoid stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to molecule of bacterial origin	IEA Inferred from Electronic Annotation more info
involved_in cellular response to molecule of bacterial origin	ISO Inferred from Sequence Orthology more info
involved_in cellular response to toxic substance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circadian regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in circadian regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in circumferential growth involved in left ventricle morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gland development	ISO Inferred from Sequence Orthology more info
involved_in glomerulus morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in immune system process	ISO Inferred from Sequence Orthology more info
involved_in intracellular receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in kidney morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in liver development	ISO Inferred from Sequence Orthology more info
involved_in lymphocyte homeostasis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of T cell mediated immune response to tumor cell	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of T cell mediated immune response to tumor cell	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell mediated immune response to tumor cell	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of calcium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of osteoblast differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of osteoblast proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of systemic arterial blood pressure	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vasoconstriction	ISO Inferred from Sequence Orthology more info
involved_in nitric oxide metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in omega-hydroxylase P450 pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ovarian follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of RNA polymerase II transcription preinitiation complex assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell size	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of growth rate	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in post-embryonic hemopoiesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within prostate gland development	ISO Inferred from Sequence Orthology more info
involved_in protein localization to nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reactive oxygen species biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of B cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in regulation of B cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of adaptive immune response	ISO Inferred from Sequence Orthology more info
involved_in regulation of adaptive immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell cycle	TAS Traceable Author Statement more info	PubMed
involved_in regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within reproductive structure development	ISO Inferred from Sequence Orthology more info
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to toxic substance	IEA Inferred from Electronic Annotation more info
involved_in response to toxic substance	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in rhythmic process	IEA Inferred from Electronic Annotation more info
involved_in spleen development	ISO Inferred from Sequence Orthology more info
involved_in tissue remodeling	IEP Inferred from Expression Pattern more info	PubMed
involved_in transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in vasculature development	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of aryl hydrocarbon receptor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of nuclear aryl hydrocarbon receptor complex	IEA Inferred from Electronic Annotation more info
part_of nuclear aryl hydrocarbon receptor complex	ISO Inferred from Sequence Orthology more info
part_of nuclear aryl hydrocarbon receptor complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: aryl hydrocarbon receptor

Names: ah receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001308254.1 → NP_001295183.1 aryl hydrocarbon receptor isoform 2

See identical proteins and their annotated locations for NP_001295183.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice junction in the 3' end of the coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A6HB98, A8YPR0, G3V6M2

Related

ENSRNOP00000006618.6, ENSRNOT00000006618.8

Conserved Domains (5) summary

smart00353
Location:36 → 77

HLH; helix loop helix domain

smart00091
Location:111 → 177

PAS; PAS domain

cd00130
Location:280 → 384

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam00989
Location:111 → 181

PAS; PAS fold

pfam08447
Location:295 → 380

PAS_3; PAS fold
NM_001308255.1 → NP_001295184.1 aryl hydrocarbon receptor isoform 3

See identical proteins and their annotated locations for NP_001295184.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice junction in the 3' end of the coding sequence compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A6HB96, A8YPQ9

Conserved Domains (5) summary

smart00353
Location:36 → 77

HLH; helix loop helix domain

smart00091
Location:111 → 177

PAS; PAS domain

cd00130
Location:280 → 384

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam00989
Location:111 → 181

PAS; PAS fold

pfam08447
Location:295 → 380

PAS_3; PAS fold
NM_013149.3 → NP_037281.3 aryl hydrocarbon receptor isoform 1

See identical proteins and their annotated locations for NP_037281.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

O88930, O89105, P41738

UniProtKB/TrEMBL

A6HB97, A8YPR4

Conserved Domains (5) summary

smart00091
Location:111 → 177

PAS; PAS domain

cd00083
Location:36 → 77

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

cd00130
Location:280 → 384

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam00989
Location:111 → 181

PAS; PAS fold

pfam08447
Location:295 → 380

PAS_3; PAS fold

RNA

NR_131775.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses an alternate splice junction in the 3' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

JAXUCZ010000006
NR_131776.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (5) uses an alternate splice junction in the 3' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

JAXUCZ010000006