Anxa5 annexin A5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Anxa5provided by RGD
Official Full Name: annexin A5provided by RGD
Primary source: RGD:2120
See related: Ensembl:ENSRNOG00000014453 AllianceGenome:RGD:2120
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: LC5; Anx5; CPB-I
Summary: Enables several functions, including P-type calcium transporter activity; calcium-dependent phospholipid binding activity; and receptor tyrosine kinase binding activity. Involved in several processes, including cellular response to gonadotropin-releasing hormone; cellular response to lead ion; and negative regulation of prolactin secretion. Located in several cellular components, including Z disc; intercalated disc; and perikaryon. Biomarker of several diseases, including Wilson disease; cryptorchidism; glomerulonephritis; hyperthyroidism; and myocardial infarction. Human ortholog(s) of this gene implicated in autoimmune disease of the nervous system; myocardial infarction; and systemic scleroderma. Orthologous to human ANXA5 (annexin A5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 1032.8), Heart (RPKM 711.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q25

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (121242133..121272935, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (119314007..119344703, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (123162477..123194730, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The increment of annexin V-positive microvesicles versus annexin V-negative microvesicles in CSF of an animal model of Alzheimer's disease.
Title: The increment of annexin V-positive microvesicles versus annexin V-negative microvesicles in CSF of an animal model of Alzheimer's disease.
Sequential preovulatory expression of a gonadotropin-releasing hormone-inducible gene, Nr4a3, and its suppressor Anxa5 in the pituitary gland of female rats.
Title: Sequential preovulatory expression of a gonadotropin-releasing hormone-inducible gene, Nr4a3, and its suppressor Anxa5 in the pituitary gland of female rats.
These results identify a novel role for ANXA5 specifically in the recognition and binding step of clearance phagocytosis, which is essential to retinal physiology.
Title: Annexin A5 regulates surface αvβ5 integrin for retinal clearance phagocytosis.
further analysis showed that miR-124-3p enhanced the viability of 6-OHDA-treated PC12 or SH-SY5Y cells by targeting ANXA5, which was associated with the stimulation of the ERK pathway.
Title: The Neuroprotective Role of MiR-124-3p in a 6-Hydroxydopamine-Induced Cell Model of Parkinson's Disease via the Regulation of ANAX5.
These results are the first to demonstrate the distribution of annexin A5 in the mammary glands of lactating rats, and the enhanced expression in mammary epithelial cells after lactation suggests its involvement in mammary epithelial cell involution.
Title: Immunohistochemical localization of annexin a5 in the mammary gland of rats: up-regulation of expression by pup removal.
Pituitary luteinizing hormone promotes annexin A5 synthesis in Leydig cells.
Title: Stimulation of annexin A5 expression by gonadotropin releasing hormone (GnRH) in the Leydig cells of rats.
Annexin V has an interfacial basic cluster locus that is required for trimerization and membrane phospholipid binding
Title: Interfacial basic cluster in annexin V couples phospholipid binding and trimer formation on membrane surfaces.
results demonstrate that endogenous pituitary annexin 5 exerts an inhibitory effect on prolactin release
Title: Annexin 5 inhibits thyrotropin releasing hormone (TRH) stimulated prolactin release in the primary culture of rat anterior pituitary cells.
results demonstrate that prolactin decreases annexin 5 mRNA in the luteal cells during pseudopregnancy possibly by suppressing action of gonadotropin releasing hormone
Title: Prolactin inhibits annexin 5 expression and apoptosis in the corpus luteum of pseudopregnant rats: involvement of local gonadotropin-releasing hormone.
biophysical analysis of adsorption and two-dimensional self-assembly of annexin A5 on supported lipid bilayers
Title: On the kinetics of adsorption and two-dimensional self-assembly of annexin A5 on supported lipid bilayers.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH129836 (e-PCR)
- UniSTS:213124

RH94545 (e-PCR)
- UniSTS:119793

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables P-type calcium transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipid binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium-dependent phospholipid binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent phospholipid binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables calcium-dependent phospholipid binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables peptide hormone binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylserine binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylserine binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor tyrosine kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in blood coagulation	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in cellular response to gonadotropin-releasing hormone	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to lead ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of blood coagulation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of coagulation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of prolactin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of flagellated sperm motility	IDA Inferred from Direct Assay more info	PubMed
involved_in response to calcium ion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to organic substance	ISO Inferred from Sequence Orthology more info
involved_in response to thyroid hormone	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in endothelial microparticle	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in intercalated disc	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
is_active_in sarcolemma	IBA Inferred from Biological aspect of Ancestor more info
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in zymogen granule membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: annexin A5

Names: Annexin V; CBP-I; PAP-I; PP4; VAC-alpha; anchorin CII; annexin-5; calphobindin I; endonexin II; lipocortin V; placental anticoagulant protein 4; placental anticoagulant protein I; thromboplastin inhibitor; vascular anticoagulant-alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.