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Il1r1 interleukin 1 receptor type 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25663, updated on 13-Apr-2024

Summary

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Official Symbol
Il1r1provided by RGD
Official Full Name
interleukin 1 receptor type 1provided by RGD
Primary source
RGD:2892
See related
Ensembl:ENSRNOG00000014504 AllianceGenome:RGD:2892
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
IL-1R-1; IL-1RT1; IL-1RT-1; IL-1R-alpha
Summary
Enables ionotropic glutamate receptor binding activity. Involved in several processes, including interleukin-1-mediated signaling pathway; positive regulation of neuron migration; and response to odorant. Located in several cellular components, including axon; cell surface; and postsynaptic density. Part of protein-containing complex. Biomarker of pulpitis. Human ortholog(s) of this gene implicated in systemic scleroderma and type 1 diabetes mellitus. Orthologous to human IL1R1 (interleukin 1 receptor type 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 238.9), Lung (RPKM 115.5) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
9q22
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (50000558..50076579)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (42504917..42580958)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (46962291..47038139)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094675 Neighboring gene H3.3 histone A like 3 Neighboring gene interleukin 1 receptor-like 2 Neighboring gene interleukin 1 receptor-like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Interleukin-1 receptor type 1 is overexpressed in neurons but not in glial cells within the rat superficial spinal dorsal horn in complete Freund adjuvant-induced inflammatory pain. Holló K, et al. J Neuroinflammation, 2017 Jun 23. PMID 28645297, Free PMC Article
  2. Interleukin-1 beta guides the migration of cortical neurons. Ma L, et al. J Neuroinflammation, 2014 Jun 21. PMID 24950657, Free PMC Article
  3. Sensory pulpal nerve fibres and trigeminal ganglion neurons express IL-1RI: a potential mechanism for development of inflammatory hyperalgesia. Bletsa A, et al. Int Endod J, 2009 Nov. PMID 19732182
  4. Additive anti-hyperalgesia of electroacupuncture and intrathecal antisense oligodeoxynucleotide to interleukin-1 receptor type I on carrageenan-induced inflammatory pain in rats. Song MJ, et al. Brain Res Bull, 2009 Mar 30. PMID 19022353
  5. DNA microarray analysis of the effect on inflammation in patients treated with acupuncture for allergic rhinitis. Shiue HS, et al. J Altern Complement Med, 2008 Jul. PMID 18637763

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inhibition of IL1R1 or CASP4 attenuates spinal cord injury through ameliorating NLRP3 inflammasome-induced pyroptosis.
    Title: Inhibition of IL1R1 or CASP4 attenuates spinal cord injury through ameliorating NLRP3 inflammasome-induced pyroptosis.
  2. Inhibition of MLKL-dependent necroptosis via downregulating interleukin-1R1 contributes to neuroprotection of hypoxic preconditioning in transient global cerebral ischemic rats.
    Title: Inhibition of MLKL-dependent necroptosis via downregulating interleukin-1R1 contributes to neuroprotection of hypoxic preconditioning in transient global cerebral ischemic rats.
  3. Role of macrophage-mediated Toll-like receptor 4-interleukin-1R signaling in ectopic tongue pain associated with tooth pulp inflammation.
    Title: Role of macrophage-mediated Toll-like receptor 4-interleukin-1R signaling in ectopic tongue pain associated with tooth pulp inflammation.
  4. An increase in expression of IL-1R1 was found in neurons of spinal dorsal horn in an inflammatory pain model.
    Title: Interleukin-1 receptor type 1 is overexpressed in neurons but not in glial cells within the rat superficial spinal dorsal horn in complete Freund adjuvant-induced inflammatory pain.
  5. The work identifies a pathogenic role of postnatal IL1b/IL-1R1 pathway and subsequent prolonged prominent increase of endocannabinoid signaling in adult seizure susceptibility following prolonged febrile seizures.
    Title: Transient increase of interleukin-1β after prolonged febrile seizures promotes adult epileptogenesis through long-lasting upregulating endocannabinoid signaling.
  6. Activity of Il-1 in parturition is regulated by progesterone via Il1R1/Il1R2/Il-1RAcp pathway.
    Title: Interleukin (IL)-1 in rat parturition: IL-1 receptors 1 and 2 and accessory proteins abundance in pregnant rat uterus at term - regulation by progesterone.
  7. IL-1beta-induced proliferation is possibly mediated by the IL-1R1, JNK, and AP-1 pathways in rat hepatic stellate cells.
    Title: Mechanism of interleukin-1β-induced proliferation in rat hepatic stellate cells from different levels of signal transduction.
  8. In the amygdala significant up-regulation of interleukin-1 receptor 1 (IL1r1), interleukin-4 receptor (IL4r), fibroblast growth factor 13 (FGF13), and cathepsin-H (CtsH) was observed in males in response to the odor of cornnuts only.
    Title: Novel odors affect gene expression for cytokines and proteinases in the rat amygdala and hippocampus.
  9. YiGanKang Decoction could not decrease IL-1RI expression, but it could inhibit activity of AP-1 in rat HSCs induced by IL-1beta.
    Title: Differential role of YiGanKang decoction in IL-1β induction of IL-1RI and AP-1 in rat hepatic stellate cell.
  10. Data show that IL-1RI and its accessory proteins MyD88 and IL-1RAcP are differently distributed in the hippocampus and in the subcellular compartments of primary hippocampal neurons.
    Title: Distribution of interleukin-1 receptor complex at the synaptic membrane driven by interleukin-1β and NMDA stimulation.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables NAD+ nucleosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables interleukin-1 binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables interleukin-1 binding ISO
Inferred from Sequence Orthology
more info
  
enables interleukin-1 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables interleukin-1 receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables interleukin-1, type I, activating receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables ionotropic glutamate receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables platelet-derived growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables protease binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to glucose stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in heat acclimation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in interleukin-1-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in interleukin-1-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in interleukin-1-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of T-helper 1 cell cytokine production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of T-helper 1 cell cytokine production ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within positive regulation of interleukin-1-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neuron migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of neutrophil extravasation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of type II interferon production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of type II interferon production ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in response to epidermal growth factor IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to interleukin-1 IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to interleukin-1 ISO
Inferred from Sequence Orthology
more info
  
involved_in response to nitric oxide IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to odorant IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to transforming growth factor beta IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
interleukin-1 receptor type 1
Names
CD121 antigen-like family member A
interleukin 1 beta receptor type 1 short transmembrane form
interleukin 1 beta receptor type 1 soluble form
interleukin 1 bete receptor type 1 long transmembrane form
interleukin-1 receptor alpha
interleukin-1 receptor type I
NP_001399522.1
NP_001399523.1
XP_006244809.1
XP_006244810.1
XP_006244811.1
XP_006244812.1
XP_006244813.1
XP_006244814.1
XP_008765215.1
XP_038939020.1
XP_063122809.1
XP_063122810.1
XP_063122811.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001412593.1 → NP_001399522.1  interleukin-1 receptor type 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    Q05KR0

  2. NM_001412594.1 → NP_001399523.1  interleukin-1 receptor type 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    Q05KR0
    Related
    ENSRNOP00000091937.1, ENSRNOT00000108650.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    50000558..50076579
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063266739.1 → XP_063122809.1  interleukin-1 receptor type 1 isoform X3

    UniProtKB/TrEMBL
    Q05KR0

  2. XM_063266741.1 → XP_063122811.1  interleukin-1 receptor type 1 isoform X3

    UniProtKB/TrEMBL
    Q05KR0

  3. XM_063266740.1 → XP_063122810.1  interleukin-1 receptor type 1 isoform X3

    UniProtKB/TrEMBL
    Q05KR0

  4. XM_006244747.5 → XP_006244809.1  interleukin-1 receptor type 1 isoform X1

    See identical proteins and their annotated locations for XP_006244809.1

    UniProtKB/Swiss-Prot
    Q02955
    UniProtKB/TrEMBL
    A6INN1, F7FMA2, Q05KR1
    Related
    ENSRNOP00000019673.3
    Conserved Domains (5) summary
    cd05757
    Location:144 → 236
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    smart00255
    Location:401 → 556
    TIR; Toll - interleukin 1 - resistance
    smart00410
    Location:251 → 344
    IG_like; Immunoglobulin like
    pfam13927
    Location:242 → 333
    Ig_3; Immunoglobulin domain
    cl11960
    Location:47 → 130
    Ig; Immunoglobulin domain

  5. XM_006244752.5 → XP_006244814.1  interleukin-1 receptor type 1 isoform X3

    See identical proteins and their annotated locations for XP_006244814.1

    UniProtKB/Swiss-Prot
    Q02955
    UniProtKB/TrEMBL
    Q05KR0
    Conserved Domains (4) summary
    smart00255
    Location:384 → 539
    TIR; Toll - interleukin 1 - resistance
    cd00096
    Location:128 → 133
    Ig; Ig strand A [structural motif]
    cd20932
    Location:226 → 329
    Ig3_IL1R_like; Third immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains
    cl11960
    Location:128 → 217
    Ig; Immunoglobulin domain

  6. XM_006244748.5 → XP_006244810.1  interleukin-1 receptor type 1 isoform X2

    See identical proteins and their annotated locations for XP_006244810.1

    UniProtKB/Swiss-Prot
    Q02955
    UniProtKB/TrEMBL
    A0A0G2K6N4, A6INM9
    Related
    ENSRNOP00000073880.1
    Conserved Domains (5) summary
    cd05757
    Location:130 → 222
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    smart00255
    Location:387 → 542
    TIR; Toll - interleukin 1 - resistance
    smart00410
    Location:237 → 330
    IG_like; Immunoglobulin like
    pfam13927
    Location:228 → 319
    Ig_3; Immunoglobulin domain
    cl11960
    Location:33 → 116
    Ig; Immunoglobulin domain

  7. XM_039083092.2 → XP_038939020.1  interleukin-1 receptor type 1 isoform X3

    UniProtKB/Swiss-Prot
    Q02955
    UniProtKB/TrEMBL
    Q05KR0
    Related
    ENSRNOP00000075417.2
    Conserved Domains (4) summary
    smart00255
    Location:384 → 539
    TIR; Toll - interleukin 1 - resistance
    cd00096
    Location:128 → 133
    Ig; Ig strand A [structural motif]
    cd20932
    Location:226 → 329
    Ig3_IL1R_like; Third immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains
    cl11960
    Location:128 → 217
    Ig; Immunoglobulin domain

  8. XM_006244750.5 → XP_006244812.1  interleukin-1 receptor type 1 isoform X3

    See identical proteins and their annotated locations for XP_006244812.1

    UniProtKB/Swiss-Prot
    Q02955
    UniProtKB/TrEMBL
    Q05KR0
    Conserved Domains (4) summary
    smart00255
    Location:384 → 539
    TIR; Toll - interleukin 1 - resistance
    cd00096
    Location:128 → 133
    Ig; Ig strand A [structural motif]
    cd20932
    Location:226 → 329
    Ig3_IL1R_like; Third immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains
    cl11960
    Location:128 → 217
    Ig; Immunoglobulin domain

  9. XM_006244749.5 → XP_006244811.1  interleukin-1 receptor type 1 isoform X3

    See identical proteins and their annotated locations for XP_006244811.1

    UniProtKB/Swiss-Prot
    Q02955
    UniProtKB/TrEMBL
    Q05KR0
    Conserved Domains (4) summary
    smart00255
    Location:384 → 539
    TIR; Toll - interleukin 1 - resistance
    cd00096
    Location:128 → 133
    Ig; Ig strand A [structural motif]
    cd20932
    Location:226 → 329
    Ig3_IL1R_like; Third immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains
    cl11960
    Location:128 → 217
    Ig; Immunoglobulin domain

  10. XM_008766993.3 → XP_008765215.1  interleukin-1 receptor type 1 isoform X3

    See identical proteins and their annotated locations for XP_008765215.1

    UniProtKB/Swiss-Prot
    Q02955
    UniProtKB/TrEMBL
    Q05KR0
    Conserved Domains (4) summary
    smart00255
    Location:384 → 539
    TIR; Toll - interleukin 1 - resistance
    cd00096
    Location:128 → 133
    Ig; Ig strand A [structural motif]
    cd20932
    Location:226 → 329
    Ig3_IL1R_like; Third immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains
    cl11960
    Location:128 → 217
    Ig; Immunoglobulin domain

  11. XM_006244751.4 → XP_006244813.1  interleukin-1 receptor type 1 isoform X3

    See identical proteins and their annotated locations for XP_006244813.1

    UniProtKB/Swiss-Prot
    Q02955
    UniProtKB/TrEMBL
    Q05KR0
    Conserved Domains (4) summary
    smart00255
    Location:384 → 539
    TIR; Toll - interleukin 1 - resistance
    cd00096
    Location:128 → 133
    Ig; Ig strand A [structural motif]
    cd20932
    Location:226 → 329
    Ig3_IL1R_like; Third immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains
    cl11960
    Location:128 → 217
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q02955.1 GenPept UniProtKB/Swiss-Prot:Q02955

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