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Fn1 fibronectin 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25661, updated on 4-Jan-2025

Summary

Official Symbol
Fn1provided by RGD
Official Full Name
fibronectin 1provided by RGD
Primary source
RGD:2624
See related
EnsemblRapid:ENSRNOG00000014288 AllianceGenome:RGD:2624
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
fn-1; FIBNEC
Summary
Enables mercury ion binding activity and protease binding activity. Involved in several processes, including cellular response to amyloid-beta; cellular response to mercury ion; and cellular response to platelet-derived growth factor stimulus. Located in basement membrane and extracellular space. Used to study diabetic angiopathy; hypertension; and renovascular hypertension. Biomarker of several diseases, including artery disease (multiple); calcium oxalate nephrolithiasis; iron deficiency anemia; membranoproliferative glomerulonephritis; and ureteral obstruction. Human ortholog(s) of this gene implicated in calcium oxalate nephrolithiasis; membranoproliferative glomerulonephritis; and spondylometaphyseal dysplasia corner fracture type. Orthologous to human FN1 (fibronectin 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Liver (RPKM 1817.5), Lung (RPKM 1002.6) and 6 other tissues See more
Orthologs
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Genomic context

See Fn1 in Genome Data Viewer
Location:
9q33
Exon count:
46
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (80645507..80714200, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (73196044..73264695, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (78900111..78969018, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480587 Neighboring gene 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase Neighboring gene uncharacterized LOC120094699 Neighboring gene uncharacterized LOC102554186 Neighboring gene nucleolar protein 56-like

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables extracellular matrix structural constituent PubMed 
enables heparin binding  
enables identical protein binding  
enables identical protein binding  
enables integrin binding  
enables integrin binding  
enables integrin binding  
enables mercury ion binding PubMed 
enables peptidase activator activity  
enables peptidase activator activity  
enables protease binding  
enables protease binding PubMed 
enables protease binding  
enables protein binding PubMed 
enables proteoglycan binding  
enables proteoglycan binding  
enables proteoglycan binding  
enables receptor ligand activity  
enables receptor ligand activity  
enables signaling receptor binding  
Items 1 - 25 of 73
Process Evidence Code Pubs
involved_in acute-phase response  
involved_in angiogenesis  
involved_in biological process involved in interaction with symbiont  
involved_in calcium-independent cell-matrix adhesion  
acts_upstream_of_or_within calcium-independent cell-matrix adhesion  
involved_in cell adhesion  
acts_upstream_of_or_within cell adhesion  
involved_in cell-matrix adhesion  
involved_in cell-matrix adhesion PubMed 
acts_upstream_of_or_within cell-matrix adhesion  
involved_in cell-substrate junction assembly  
involved_in cell-substrate junction assembly  
acts_upstream_of_or_within cell-substrate junction assembly  
involved_in cellular response to BMP stimulus PubMed 
involved_in cellular response to amyloid-beta PubMed 
involved_in cellular response to angiotensin PubMed 
involved_in cellular response to glucose stimulus PubMed 
involved_in cellular response to interleukin-1 PubMed 
involved_in cellular response to lipopolysaccharide PubMed 
involved_in cellular response to mercury ion PubMed 
involved_in cellular response to platelet-derived growth factor stimulus PubMed 
involved_in cellular response to prostaglandin E stimulus PubMed 
involved_in cellular response to transforming growth factor beta stimulus PubMed 
involved_in cellular response to vascular endothelial growth factor stimulus PubMed 
involved_in endodermal cell differentiation  
involved_in endodermal cell differentiation  
involved_in extracellular matrix organization PubMed 
involved_in glial cell migration PubMed 
involved_in heart development  
involved_in integrin activation  
involved_in integrin activation  
involved_in integrin-mediated signaling pathway  
involved_in integrin-mediated signaling pathway  
involved_in negative regulation of apoptotic process PubMed 
involved_in negative regulation of collagen biosynthetic process PubMed 
involved_in negative regulation of monocyte activation  
involved_in negative regulation of monocyte activation  
involved_in negative regulation of transforming growth factor beta production  
involved_in negative regulation of transforming growth factor beta production  
involved_in nervous system development  
involved_in neural crest cell migration involved in autonomic nervous system development  
involved_in neural crest cell migration involved in autonomic nervous system development  
involved_in ossification PubMed 
involved_in peptide cross-linking  
involved_in positive regulation of axon extension  
acts_upstream_of_or_within positive regulation of axon extension  
involved_in positive regulation of cell migration PubMed 
involved_in positive regulation of cell population proliferation  
involved_in positive regulation of chemotaxis PubMed 
involved_in positive regulation of fibroblast proliferation  
involved_in positive regulation of fibroblast proliferation  
involved_in positive regulation of gene expression  
involved_in positive regulation of gene expression  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
involved_in positive regulation of substrate-dependent cell migration, cell attachment to substrate  
involved_in positive regulation of substrate-dependent cell migration, cell attachment to substrate  
involved_in regulation of ERK1 and ERK2 cascade  
involved_in regulation of ERK1 and ERK2 cascade  
involved_in regulation of cell shape  
involved_in regulation of protein phosphorylation  
involved_in response to activity PubMed 
involved_in response to glucocorticoid PubMed 
involved_in response to iron ion PubMed 
involved_in response to ischemia PubMed 
involved_in response to muscle activity  
involved_in response to muscle activity  
involved_in response to ozone PubMed 
involved_in response to xenobiotic stimulus PubMed 
involved_in substrate adhesion-dependent cell spreading  
involved_in substrate adhesion-dependent cell spreading  
involved_in wound healing  
acts_upstream_of_or_within wound healing  
Items 1 - 25 of 73
Component Evidence Code Pubs
located_in apical plasma membrane  
located_in apical plasma membrane  
located_in basement membrane PubMed 
located_in basement membrane  
located_in basement membrane  
located_in collagen-containing extracellular matrix  
located_in collagen-containing extracellular matrix  
located_in endoplasmic reticulum-Golgi intermediate compartment  
located_in endoplasmic reticulum-Golgi intermediate compartment  
located_in extracellular exosome  
located_in extracellular exosome  
is_active_in extracellular matrix  
located_in extracellular matrix  
located_in extracellular space PubMed 
located_in extracellular space  
is_active_in extracellular space  
located_in extracellular space  
part_of fibrinogen complex  
part_of fibrinogen complex  

General protein information

Preferred Names
fibronectin
Names
FN
fibronectin 2
fibronectin 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019143.2NP_062016.2  fibronectin precursor

    See identical proteins and their annotated locations for NP_062016.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    P04937, Q6LDX9
    UniProtKB/TrEMBL
    A0A096P6L8, A6KFG8
    Related
    ENSRNOP00000019772.4, ENSRNOT00000019772.8
    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:187231
    FN1; Fibronectin type 1 domain
    cd00061
    Location:23842423
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19942074
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:232271
    fn1; Fibronectin type I domain
    pfam00041
    Location:15391620
    fn3; Fibronectin type III domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    80645507..80714200 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006245156.5XP_006245218.1  fibronectin isoform X7

    See identical proteins and their annotated locations for XP_006245218.1

    UniProtKB/TrEMBL
    A0A8I5ZXR2, A6KFG4
    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:187231
    FN1; Fibronectin type 1 domain
    cd00061
    Location:22032242
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:18131893
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:232271
    fn1; Fibronectin type I domain
    pfam00041
    Location:14481529
    fn3; Fibronectin type III domain
  2. XM_006245159.5XP_006245221.1  fibronectin isoform X11

    UniProtKB/TrEMBL
    A6KFG7
    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:187231
    FN1; Fibronectin type 1 domain
    cd00061
    Location:20832122
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:18131893
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:232271
    fn1; Fibronectin type I domain
    pfam00041
    Location:14481529
    fn3; Fibronectin type III domain
  3. XM_006245157.5XP_006245219.1  fibronectin isoform X8

    UniProtKB/TrEMBL
    A0A8I5ZXR2
    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:187231
    FN1; Fibronectin type 1 domain
    cd00061
    Location:21782217
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:18131893
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:232271
    fn1; Fibronectin type I domain
    pfam00041
    Location:14481529
    fn3; Fibronectin type III domain
  4. XM_006245158.5XP_006245220.1  fibronectin isoform X10

    UniProtKB/TrEMBL
    A6KFG7
    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:187231
    FN1; Fibronectin type 1 domain
    cd00061
    Location:21732212
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19031983
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:232271
    fn1; Fibronectin type I domain
    pfam00041
    Location:14481529
    fn3; Fibronectin type III domain
  5. XM_006245153.5XP_006245215.1  fibronectin isoform X5

    UniProtKB/Swiss-Prot
    P04937, Q6LDX9
    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:187231
    FN1; Fibronectin type 1 domain
    cd00061
    Location:22682307
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19031983
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:232271
    fn1; Fibronectin type I domain
    pfam00041
    Location:14481529
    fn3; Fibronectin type III domain
  6. XM_006245152.5XP_006245214.1  fibronectin isoform X3

    See identical proteins and their annotated locations for XP_006245214.1

    UniProtKB/Swiss-Prot
    P04937, Q6LDX9
    UniProtKB/TrEMBL
    A0A8I6A5M1, A6KFG5
    Related
    ENSRNOP00000087332.1, ENSRNOT00000110905.2
    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:187231
    FN1; Fibronectin type 1 domain
    cd00061
    Location:22932332
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19031983
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:232271
    fn1; Fibronectin type I domain
    pfam00041
    Location:14481529
    fn3; Fibronectin type III domain
  7. XM_017596301.3XP_017451790.1  fibronectin isoform X9

    UniProtKB/TrEMBL
    A6KFG7
  8. XM_039083090.2XP_038939018.1  fibronectin isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZXR2
    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:187231
    FN1; Fibronectin type 1 domain
    cd00061
    Location:22692308
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19041984
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:232271
    fn1; Fibronectin type I domain
    pfam00041
    Location:15391620
    fn3; Fibronectin type III domain
  9. XM_006245151.5XP_006245213.1  fibronectin isoform X2

    See identical proteins and their annotated locations for XP_006245213.1

    UniProtKB/TrEMBL
    A0A8I5ZXR2, A6KFG6, F1LST1
    Related
    ENSRNOP00000054395.4, ENSRNOT00000057585.6
    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:187231
    FN1; Fibronectin type 1 domain
    cd00061
    Location:22942333
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19041984
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:232271
    fn1; Fibronectin type I domain
    pfam00041
    Location:15391620
    fn3; Fibronectin type III domain
  10. XM_006245154.5XP_006245216.1  fibronectin isoform X6

    UniProtKB/TrEMBL
    A6KFG7
    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:187231
    FN1; Fibronectin type 1 domain
    cd00061
    Location:22642303
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19942074
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:232271
    fn1; Fibronectin type I domain
    pfam00041
    Location:15391620
    fn3; Fibronectin type III domain
  11. XM_006245150.5XP_006245212.1  fibronectin isoform X1

    UniProtKB/Swiss-Prot
    P04937, Q6LDX9
    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:187231
    FN1; Fibronectin type 1 domain
    cd00061
    Location:23592398
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19942074
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:232271
    fn1; Fibronectin type I domain
    pfam00041
    Location:15391620
    fn3; Fibronectin type III domain
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