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Ptgfr prostaglandin F receptor [ Rattus norvegicus (Norway rat) ]

Gene ID: 25652, updated on 13-Apr-2024

Summary

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Official Symbol
Ptgfrprovided by RGD
Official Full Name
prostaglandin F receptorprovided by RGD
Primary source
RGD:3436
See related
Ensembl:ENSRNOG00000046468 AllianceGenome:RGD:3436
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
PF2AR
Summary
Predicted to enable prostaglandin F receptor activity. Predicted to be involved in several processes, including calcium-mediated signaling using intracellular calcium source; cellular response to prostaglandin D stimulus; and response to estradiol. Predicted to act upstream of or within negative regulation of apoptotic process and response to lipopolysaccharide. Predicted to be located in cytoplasm and extracellular region. Predicted to be active in plasma membrane. Orthologous to human PTGFR (prostaglandin F receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 285.1), Liver (RPKM 73.0) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
2q45
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (243390820..243426647, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (240731185..240766674, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (257005813..257039036, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene interferon-induced protein 44 Neighboring gene interferon-induced protein 44-like Neighboring gene proteasome maturation protein pseudogene Neighboring gene protein tyrosine phosphatase 4A1 like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Prostaglandin F receptor expression in intrauterine tissues of pregnant rats. Anadol E, et al. J Vet Sci, 2014. PMID 24136214, Free PMC Article
  2. Role of the prostanoid FP receptor in action potential generation and phenotypic transformation of NRK fibroblasts. Almirza WH, et al. Cell Signal, 2008 Nov. PMID 18703136
  3. Characterization and regulation of a mRNA encoding the prostaglandin F2alpha receptor in the rat ovary. Olofsson JI, et al. Mol Cell Endocrinol, 1996 Oct 14. PMID 8912810
  4. Cloning and expression of a cDNA for rat prostaglandin F2 alpha receptor. Kitanaka J, et al. Prostaglandins, 1994 Jul. PMID 7972878
  5. Exacerbation of intracranial aneurysm and aortic dissection in hypertensive rat treated with the prostaglandin F-receptor antagonist AS604872. Fukuda M, et al. J Pharmacol Sci, 2014. PMID 25341845

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Prostaglandin F-receptor antagonist AS604872 exacerbates vascular inflammation in hypertensive animals, facilitating intracranial aneurysm formation and aortic dissection.
    Title: Exacerbation of intracranial aneurysm and aortic dissection in hypertensive rat treated with the prostaglandin F-receptor antagonist AS604872.
  2. There was an increase rat prostaglandin F receptor expression in rat uterus with advancing gestation, a marked elevation of expression at term, and a concominant decrease during the postpartum period.
    Title: Prostaglandin F receptor expression in intrauterine tissues of pregnant rats.
  3. Data found that FP localizes in neuronal somata and dendrites but not in ependymal cells, tanycytes, or endothelial cells. Immunohistochemical analysis of serial sections showed the colocalization of FP and PGFS I.
    Title: Colocalization of prostaglandin F(2alpha) receptor FP and prostaglandin F synthase-I in the spinal cord.
  4. Activity of PGF(2alpha) by putative pacemaker cells underlies the generation of calcium action potentials in normal rat kidney monolayers.
    Title: Role of the prostanoid FP receptor in action potential generation and phenotypic transformation of NRK fibroblasts.
  5. NADPH oxidase is involved in prostaglandin F2alpha-induced hypertrophy of vascular smooth muscle cells: induction of NOX1 by PGF2alpha.
    Title: NADPH oxidase is involved in prostaglandin F2alpha-induced hypertrophy of vascular smooth muscle cells: induction of NOX1 by PGF2alpha.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables prostaglandin F receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables prostaglandin F receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium-mediated signaling using intracellular calcium source ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to prostaglandin D stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in response to estradiol ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
prostaglandin F2-alpha receptor
Names
PGF receptor
PGF2-alpha receptor
prostanoid FP receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013115.2 → NP_037247.1  prostaglandin F2-alpha receptor

    See identical proteins and their annotated locations for NP_037247.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/Swiss-Prot
    P43118, Q62787
    UniProtKB/TrEMBL
    A6HWJ3
    Related
    ENSRNOP00000065253.1, ENSRNOT00000071195.2
    Conserved Domains (1) summary
    cd15145
    Location:27 → 316
    7tmA_FP; prostaglandin F2-alpha receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    243390820..243426647 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006233486.5 → XP_006233548.1  prostaglandin F2-alpha receptor isoform X1

    See identical proteins and their annotated locations for XP_006233548.1

    UniProtKB/Swiss-Prot
    P43118, Q62787
    UniProtKB/TrEMBL
    A6HWJ3
    Conserved Domains (1) summary
    cd15145
    Location:27 → 316
    7tmA_FP; prostaglandin F2-alpha receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. XM_006233487.5 → XP_006233549.1  prostaglandin F2-alpha receptor isoform X1

    See identical proteins and their annotated locations for XP_006233549.1

    UniProtKB/Swiss-Prot
    P43118, Q62787
    UniProtKB/TrEMBL
    A6HWJ3
    Conserved Domains (1) summary
    cd15145
    Location:27 → 316
    7tmA_FP; prostaglandin F2-alpha receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43118.1 GenPept UniProtKB/Swiss-Prot:P43118

Gene LinkOut

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