Selp selectin P [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Selpprovided by RGD
Official Full Name: selectin Pprovided by RGD
Primary source: RGD:3656
See related: Ensembl:ENSRNOG00000002794 AllianceGenome:RGD:3656
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: PSELECT
Summary: Predicted to enable several functions, including fucose binding activity; heparin binding activity; and lipopolysaccharide binding activity. Involved in several processes, including leukocyte migration; regulation of cellular extravasation; and response to lipopolysaccharide. Located in external side of plasma membrane and extracellular space. Used to study acute necrotizing pancreatitis and anti-basement membrane glomerulonephritis. Biomarker of atherosclerosis; colitis; congestive heart failure; and myocardial infarction. Human ortholog(s) of this gene implicated in atopic dermatitis and myocardial infarction. Orthologous to human SELP (selectin P). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 50.5), Uterus (RPKM 16.2) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q23

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (79009379..79044994)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (76476229..76511846)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (82428914..82464629)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

P-selectin may indicate thrombotic risk assessment in atrial fibrillation
Title: Assessment of Thrombotic Risk in Atrial Fibrillation with Ultrasound Molecular Imaging of P-Selectin.
Aortic cyclooxygenase-2 and P-selectin were significantly down-regulated in plant sterols and plant sterols + tripeptides groups.
Title: Plant sterols and casein-derived tripeptides attenuate blood pressure increase in spontaneously hypertensive rats.
Clerodendron glandulosum.Coleb leaf extract attenuates in vitro macrophage differentiation and expression of VCAM-1 and P-selectin in thoracic aorta of atherogenic diet fed rats.
Title: Clerodendron glandulosum.Coleb leaf extract attenuates in vitro macrophage differentiation and expression of VCAM-1 and P-selectin in thoracic aorta of atherogenic diet fed rats.
Fibrinogen can interact with P-selectin in order to contribute to the development of atherosclerosis, high levels of fibrinogen and P-selectin can be regarded as risk factors for markers of atherosclerosis.
Title: Fibrinogen and P-selectin expression in atherosclerosis model of Sprague Dawley rat.
Renal injury after ischemia/reperfusion may relate to the strong expression of P-selectin. NO may have a protective affect by decreasing the expression of P-selectin and alleviating the adhesion, aggregation and infiltration of neutrophils.
Title: [The affection and significance of NO on the expression of P-selectin in renal injury following hind limb ischemia/reperfusion in rats].
Puerarin inhibits the expression of VCAM and P-selectin in the aorta of diabetic rats.
Title: [Study of regulation of Puerarin on blood P-selectin and the expression of aorta VCAM mRNA in diabetes].
Both baicalin and octreotide can exert some protective effects on multiple organs of rats with severe acute pancreatitis via decreased P-selectin expression.
Title: Effect of baicalin and octreotide on the expression levels of P-selectin protein in multiple organs of rats with severe acute pancreatitis.
Volatile oil of Magnolia biondii can protect the kidney in rats with diabetic nephropathy by inhibiting the expressions of P-selectin protein in serum and in renal tissue.
Title: [Volatile oil of Magnolia biondii inhibits expressions of P-selectin protein in serum and renal tissue of rats with diabetic nephropathy].
Live donor denervation and elimination of Kupffer cells down-regulates the expressions of P-selectin and ICAM-1 mRNA in grafts
Title: Donor denervation and elimination of Kupffer cells affect expression of P-selectin and ICAM-1 in liver graft.
Blockade of this molecule protects rat steatotic liver grafts from ischemia/reperfusion injury
Title: P-selectin glycoprotein ligand-1 (rPSGL-Ig)-mediated blockade of CD62 selectin molecules protects rat steatotic liver grafts from ischemia/reperfusion injury.

Submit: New GeneRIF Correction See all GeneRIFs (18)

General gene information

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Markers

RH132595 (e-PCR)
- UniSTS:215878

RH94491 (e-PCR)
- UniSTS:119739

D13Got55 (e-PCR)
- UniSTS:111842

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables calcium-dependent protein binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables fucose binding	IEA Inferred from Electronic Annotation more info
enables fucose binding	ISO Inferred from Sequence Orthology more info
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	IEA Inferred from Electronic Annotation more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	ISS Inferred from Sequence or Structural Similarity more info
enables lipopolysaccharide binding	IEA Inferred from Electronic Annotation more info
enables lipopolysaccharide binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oligosaccharide binding	IBA Inferred from Biological aspect of Ancestor more info
enables oligosaccharide binding	IEA Inferred from Electronic Annotation more info
enables oligosaccharide binding	ISO Inferred from Sequence Orthology more info
enables oligosaccharide binding	ISS Inferred from Sequence or Structural Similarity more info
enables sialic acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables sialic acid binding	IEA Inferred from Electronic Annotation more info
enables sialic acid binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	IEA Inferred from Electronic Annotation more info
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	ISO Inferred from Sequence Orthology more info
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within leukocyte cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in leukocyte cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in leukocyte migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of leukocyte migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within leukocyte migration	ISO Inferred from Sequence Orthology more info
involved_in leukocyte tethering or rolling	IBA Inferred from Biological aspect of Ancestor more info
involved_in leukocyte tethering or rolling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within leukocyte tethering or rolling	ISO Inferred from Sequence Orthology more info
involved_in leukocyte tethering or rolling	ISO Inferred from Sequence Orthology more info
involved_in leukocyte tethering or rolling	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of leukocyte migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of leukocyte migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of leukocyte tethering or rolling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of leukocyte tethering or rolling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of leukocyte tethering or rolling	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of platelet activation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of platelet activation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cellular extravasation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of integrin activation	IEA Inferred from Electronic Annotation more info
involved_in regulation of integrin activation	ISO Inferred from Sequence Orthology more info
involved_in response to cytokine	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in platelet alpha granule membrane	IEA Inferred from Electronic Annotation more info
located_in platelet alpha granule membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: P-selectin

Names: CD62 antigen-like family member P; GMP-140; LECAM3; PADGEM; granule membrane protein 140; leukocyte-endothelial cell adhesion molecule 3; platelet activation dependent granule-external membrane protein; selectin, platelet

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013114.2 → NP_037246.2 P-selectin precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

F1LNV1, Q3MID1

Related

ENSRNOP00000003759.4, ENSRNOT00000003759.5

Conserved Domains (4) summary

cd00033
Location:200 → 258

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

cd03592
Location:42 → 160

CLECT_selectins_like; C-type lectin-like domain (CTLD) of the type found in the type 1 transmembrane proteins: P(platlet)-, E(endothelial)-, and L(leukocyte)- selectins (sels)

PHA02927
Location:276 → 505

PHA02927; secreted complement-binding protein; Provisional

cd00054
Location:168 → 195

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

79009379..79044994

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006250150.5 → XP_006250212.1 P-selectin isoform X1

UniProtKB/TrEMBL

Q3MID1

Conserved Domains (4) summary

cd00033
Location:262 → 320

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

cd03592
Location:42 → 160

CLECT_selectins_like; C-type lectin-like domain (CTLD) of the type found in the type 1 transmembrane proteins: P(platlet)-, E(endothelial)-, and L(leukocyte)- selectins (sels)

PHA02927
Location:443 → 699

PHA02927; secreted complement-binding protein; Provisional

cd00054
Location:168 → 195

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...