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Atp1b1 ATPase Na+/K+ transporting subunit beta 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25650, updated on 4-Jan-2025

Summary

Official Symbol
Atp1b1provided by RGD
Official Full Name
ATPase Na+/K+ transporting subunit beta 1provided by RGD
Primary source
RGD:2170
See related
EnsemblRapid:ENSRNOG00000002934 AllianceGenome:RGD:2170
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ATPBS
Summary
Enables P-type sodium:potassium-exchanging transporter activity and protein heterodimerization activity. Involved in potassium ion transport; response to hypoxia; and sodium ion transport. Located in apical plasma membrane; basolateral plasma membrane; and caveola. Part of sodium:potassium-exchanging ATPase complex. Biomarker of sensorineural hearing loss. Human ortholog(s) of this gene implicated in essential hypertension. Orthologous to human ATP1B1 (ATPase Na+/K+ transporting subunit beta 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Kidney (RPKM 4127.8), Brain (RPKM 2796.0) and 4 other tissues See more
Orthologs
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Genomic context

See Atp1b1 in Genome Data Viewer
Location:
13q23
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (79319708..79340226, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (76786580..76807096, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (82737161..82757681, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 181 Neighboring gene basic leucine zipper nuclear factor 1 Neighboring gene NME/NM23 family member 7 Neighboring gene uncharacterized LOC120096205 Neighboring gene uncharacterized LOC120096206

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATPase activator activity  
enables ATPase activator activity  
enables ATPase activator activity  
enables ATPase binding  
enables ATPase binding  
enables P-type sodium:potassium-exchanging transporter activity PubMed 
enables P-type sodium:potassium-exchanging transporter activity  
enables P-type sodium:potassium-exchanging transporter activity  
enables protein binding PubMed 
enables protein heterodimerization activity PubMed 
enables protein kinase binding  
enables protein kinase binding  
enables protein-macromolecule adaptor activity  
enables protein-macromolecule adaptor activity  
Items 1 - 25 of 52
Process Evidence Code Pubs
involved_in ATP metabolic process  
involved_in ATP metabolic process  
acts_upstream_of_or_within blastocyst development  
involved_in cardiac muscle contraction  
involved_in cardiac muscle contraction  
involved_in cell adhesion  
involved_in establishment or maintenance of transmembrane electrochemical gradient  
involved_in innate immune response  
involved_in intracellular calcium ion homeostasis  
involved_in intracellular calcium ion homeostasis  
involved_in intracellular potassium ion homeostasis  
involved_in intracellular potassium ion homeostasis  
involved_in intracellular potassium ion homeostasis  
involved_in intracellular sodium ion homeostasis  
involved_in intracellular sodium ion homeostasis  
involved_in intracellular sodium ion homeostasis  
involved_in membrane repolarization  
involved_in membrane repolarization  
involved_in metal ion transport PubMed 
involved_in monoatomic cation transmembrane transport  
involved_in positive regulation of ATP-dependent activity  
involved_in positive regulation of P-type sodium:potassium-exchanging transporter activity  
involved_in positive regulation of potassium ion import across plasma membrane  
involved_in positive regulation of potassium ion import across plasma membrane  
involved_in positive regulation of potassium ion transmembrane transporter activity  
involved_in positive regulation of sodium ion export across plasma membrane  
involved_in positive regulation of sodium ion export across plasma membrane  
involved_in potassium ion import across plasma membrane  
involved_in potassium ion import across plasma membrane  
involved_in potassium ion import across plasma membrane  
involved_in potassium ion transport PubMed 
involved_in potassium ion transport  
involved_in protein localization to plasma membrane  
involved_in protein localization to plasma membrane  
involved_in protein stabilization  
involved_in protein stabilization  
involved_in regulation of calcium ion transmembrane transport  
involved_in regulation of calcium ion transmembrane transport  
involved_in regulation of cardiac muscle contraction by calcium ion signaling  
involved_in regulation of cardiac muscle contraction by calcium ion signaling  
involved_in regulation of gene expression  
involved_in regulation of gene expression  
involved_in relaxation of cardiac muscle  
involved_in relaxation of cardiac muscle  
involved_in response to hypoxia PubMed 
involved_in sodium ion export across plasma membrane  
involved_in sodium ion export across plasma membrane  
involved_in sodium ion export across plasma membrane  
involved_in sodium ion transmembrane transport  
involved_in sodium ion transport PubMed 
involved_in sodium ion transport  
involved_in transmembrane transport  
Items 1 - 25 of 52
Items 1 - 20 of 26
Component Evidence Code Pubs
located_in T-tubule  
located_in T-tubule  
located_in apical plasma membrane PubMed 
located_in apical plasma membrane  
located_in apical plasma membrane  
located_in basolateral plasma membrane PubMed 
located_in basolateral plasma membrane  
located_in basolateral plasma membrane  
located_in caveola PubMed 
located_in intercalated disc  
located_in intercalated disc  
located_in lateral plasma membrane  
located_in lateral plasma membrane  
located_in membrane PubMed 
located_in membrane  
located_in organelle membrane  
located_in organelle membrane  
located_in plasma membrane  
located_in sarcolemma  
located_in sarcolemma  
part_of sodium:potassium-exchanging ATPase complex  
part_of sodium:potassium-exchanging ATPase complex PubMed 
part_of sodium:potassium-exchanging ATPase complex  
part_of sodium:potassium-exchanging ATPase complex  
located_in sperm flagellum  
located_in sperm flagellum  
Items 1 - 20 of 26

General protein information

Preferred Names
sodium/potassium-transporting ATPase subunit beta-1
Names
ATPase, Na+/K+ transporting, beta 1 polypeptide
Na,K-ATPase beta 1 subunit
sodium/potassium-dependent ATPase subunit beta-1
NP_037245.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013113.2NP_037245.2  sodium/potassium-transporting ATPase subunit beta-1

    See identical proteins and their annotated locations for NP_037245.2

    Status: PROVISIONAL

    Source sequence(s)
    BC078902
    UniProtKB/Swiss-Prot
    P07340, Q63062
    UniProtKB/TrEMBL
    A0A8L2Q0J0, A6IDE6
    Related
    ENSRNOP00000003932.5, ENSRNOT00000003932.9
    Conserved Domains (1) summary
    TIGR01107
    Location:1304
    Na_K_ATPase_bet; Sodium Potassium ATPase beta subunit

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    79319708..79340226 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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