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Pde4a phosphodiesterase 4A [ Rattus norvegicus (Norway rat) ]

Gene ID: 25638, updated on 2-May-2024

Summary

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Official Symbol
Pde4aprovided by RGD
Official Full Name
phosphodiesterase 4Aprovided by RGD
Primary source
RGD:3279
See related
Ensembl:ENSRNOG00000020828 AllianceGenome:RGD:3279
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
DPDE2; PHOSA
Summary
Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity and cAMP binding activity. Involved in modulation of chemical synaptic transmission and response to xenobiotic stimulus. Located in cytosol; nucleus; and perinuclear region of cytoplasm. Is active in Schaffer collateral - CA1 synapse. Biomarker of brucellosis and visual epilepsy. Orthologous to human PDE4A (phosphodiesterase 4A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 72.2), Heart (RPKM 63.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
8q13
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (27966978..28029721)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (19690816..19753538)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (22189533..22234036)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108351660 Neighboring gene cell division cycle 37, HSP90 cochaperone Neighboring gene uncharacterized LOC134480144 Neighboring gene Kelch-like ECH-associated protein 1 Neighboring gene sphingosine-1-phosphate receptor 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. In vitro inhibition of phosphodiesterase type 4 enhances rat corpus cavernosum nerve-mediated relaxation induced by gasotransmitters. Fernandes VS, et al. Life Sci, 2022 May 1. PMID 35219697
  2. Selective changes in cytosolic β-adrenergic cAMP signals and L-type Calcium Channel regulation by Phosphodiesterases during cardiac hypertrophy. Abi-Gerges A, et al. J Mol Cell Cardiol, 2021 Jan. PMID 33184031
  3. Compartmentalized PDE4A5 Signaling Impairs Hippocampal Synaptic Plasticity and Long-Term Memory. Havekes R, et al. J Neurosci, 2016 Aug 24. PMID 27559174, Free PMC Article
  4. ERK regulation of phosphodiesterase 4 enhances dopamine-stimulated AMPA receptor membrane insertion. Song RS, et al. Proc Natl Acad Sci U S A, 2013 Sep 17. PMID 23986500, Free PMC Article
  5. β-Adrenergic cAMP signals are predominantly regulated by phosphodiesterase type 4 in cultured adult rat aortic smooth muscle cells. Zhai K, et al. PLoS One, 2012. PMID 23094097, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phosphodiesterase (PDE) 4 inhibition boosts Schwann cell myelination in a 3D regeneration model.
    Title: Phosphodiesterase (PDE) 4 inhibition boosts Schwann cell myelination in a 3D regeneration model.
  2. In vitro inhibition of phosphodiesterase type 4 enhances rat corpus cavernosum nerve-mediated relaxation induced by gasotransmitters.
    Title: In vitro inhibition of phosphodiesterase type 4 enhances rat corpus cavernosum nerve-mediated relaxation induced by gasotransmitters.
  3. Selective changes in cytosolic beta-adrenergic cAMP signals and L-type Calcium Channel regulation by Phosphodiesterases during cardiac hypertrophy.
    Title: Selective changes in cytosolic β-adrenergic cAMP signals and L-type Calcium Channel regulation by Phosphodiesterases during cardiac hypertrophy.
  4. ERK regulation of phosphodiesterase 4 enhances dopamine-stimulated AMPA receptor membrane insertion.
    Title: ERK regulation of phosphodiesterase 4 enhances dopamine-stimulated AMPA receptor membrane insertion.
  5. PDE4A upregulation during cholestatic liver injury plays a role in inflammation and fibrosis.
    Title: Rolipram attenuates bile duct ligation-induced liver injury in rats: a potential pathogenic role of PDE4.
  6. beta-adrenergic cAMP signals are predominantly regulated by phosphodiesterase type 4 in cultured adult rat aortic smooth muscle cells.
    Title: β-Adrenergic cAMP signals are predominantly regulated by phosphodiesterase type 4 in cultured adult rat aortic smooth muscle cells.
  7. These results indicate that PDE4A and PLAT may be susceptibility genes for schizophrenia in the Japanese population.
    Title: Positive association of phencyclidine-responsive genes, PDE4A and PLAT, with schizophrenia.
  8. Increased cAMP may remodel cAMP-mediated signalling events by not only increasing the expression of specific PDE4 cAMP phosphodiesterases but also by down-regulating specific isoforms, such as is shown here for PDE4A10 in cardiac myocytes.
    Title: In cardiac myocytes, cAMP elevation triggers the down-regulation of transcripts and promoter activity for cyclic AMP phosphodiesterase-4A10 (PDE4A10).
  9. cGMP and cAMP phosphodiesterase PDE4 and AMPK/NOX2 have a role in early cardiac hypertrophy induced by angiotensin II
    Title: Concerted regulation of cGMP and cAMP phosphodiesterases in early cardiac hypertrophy induced by angiotensin II.
  10. unique tissue distribution of PDE4A8, combined with the evolutionary divergence of its N-terminus, suggest that this isoform may have a specific function in regulating cAMP levels in human skeletal muscle and brain
    Title: Human PDE4A8, a novel brain-expressed PDE4 cAMP-specific phosphodiesterase that has undergone rapid evolutionary change.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3',5'-cyclic-AMP phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables 3',5'-cyclic-AMP phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
  
enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables cAMP binding IEA
Inferred from Electronic Annotation
more info
  
enables cAMP binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cAMP catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cAMP catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cAMP catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein kinase A signaling IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of protein kinase A signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in sensory perception of smell IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sensory perception of smell ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in extrinsic component of membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
3',5'-cyclic-AMP phosphodiesterase 4A
Names
PDE4A10 cAMP phosphodiesterase
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
cAMP-specific phosphodiesterase 4A
phosphodiesterase 4A, cAMP specific
phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila)
NP_001380664.1
NP_001380665.1
NP_001380666.1
NP_037233.4
XP_063121035.1
XP_063121036.1
XP_063121037.1
XP_063121038.1
XP_063121039.1
XP_063121040.1
XP_063121041.1
XP_063121042.1
XP_063121043.1
XP_063121044.1
XP_063121045.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001393735.1 → NP_001380664.1  3',5'-cyclic-AMP phosphodiesterase 4A isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    P14645, P54748, Q9EQR7
    UniProtKB/TrEMBL
    A6JNQ0
    Related
    ENSRNOP00000085157.1, ENSRNOT00000109272.1
    Conserved Domains (2) summary
    pfam00233
    Location:361 → 602
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:116 → 231
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  2. NM_001393736.1 → NP_001380665.1  3',5'-cyclic-AMP phosphodiesterase 4A isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    P14645, P54748, Q9EQR7
    UniProtKB/TrEMBL
    A0A8I5ZV79, A6JNP8
    Related
    ENSRNOP00000082776.1, ENSRNOT00000096283.1
    Conserved Domains (2) summary
    pfam00233
    Location:337 → 578
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:92 → 207
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  3. NM_001393737.1 → NP_001380666.1  3',5'-cyclic-AMP phosphodiesterase 4A isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A8I5ZUU0, A0A8I6GFN4
    Related
    ENSRNOP00000082374.1, ENSRNOT00000112455.1
    Conserved Domains (2) summary
    pfam00233
    Location:184 → 425
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:22 → 54
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  4. NM_013101.4 → NP_037233.4  3',5'-cyclic-AMP phosphodiesterase 4A isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    P14645, P54748, Q9EQR7
    UniProtKB/TrEMBL
    A6JNP9, F1M8I9
    Related
    ENSRNOP00000057815.5, ENSRNOT00000061100.6
    Conserved Domains (2) summary
    pfam00233
    Location:418 → 659
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:173 → 288
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    27966978..28029721
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063264966.1 → XP_063121036.1  3',5'-cyclic-AMP phosphodiesterase 4A isoform X2

  2. XM_063264971.1 → XP_063121041.1  3',5'-cyclic-AMP phosphodiesterase 4A isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZV79, A6JNP8

  3. XM_063264967.1 → XP_063121037.1  3',5'-cyclic-AMP phosphodiesterase 4A isoform X2

  4. XM_063264972.1 → XP_063121042.1  3',5'-cyclic-AMP phosphodiesterase 4A isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZV79, A6JNP8

  5. XM_063264970.1 → XP_063121040.1  3',5'-cyclic-AMP phosphodiesterase 4A isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZZJ4

  6. XM_063264975.1 → XP_063121045.1  3',5'-cyclic-AMP phosphodiesterase 4A isoform X7

  7. XM_063264965.1 → XP_063121035.1  3',5'-cyclic-AMP phosphodiesterase 4A isoform X1

    UniProtKB/TrEMBL
    A0A8I6ALZ5

  8. XM_063264969.1 → XP_063121039.1  3',5'-cyclic-AMP phosphodiesterase 4A isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZZJ4

  9. XM_063264968.1 → XP_063121038.1  3',5'-cyclic-AMP phosphodiesterase 4A isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZZJ4

  10. XM_063264973.1 → XP_063121043.1  3',5'-cyclic-AMP phosphodiesterase 4A isoform X5

  11. XM_063264974.1 → XP_063121044.1  3',5'-cyclic-AMP phosphodiesterase 4A isoform X6

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P54748.1 GenPept UniProtKB/Swiss-Prot:P54748

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