Ptger1 prostaglandin E receptor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ptger1provided by RGD
Official Full Name: prostaglandin E receptor 1provided by RGD
Primary source: RGD:3434
See related: Ensembl:ENSRNOG00000004094 AllianceGenome:RGD:3434
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: EP1
Summary: Enables prostaglandin E receptor activity. Involved in negative regulation of gastric emptying. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Used to study gastric ulcer. Orthologous to human PTGER1 (prostaglandin E receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 58.9), Kidney (RPKM 51.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q11

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (41374983..41379593, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (24470258..24473687, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (24799422..24803373)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Alcohol reinstatement after prolonged abstinence from alcohol drinking by female adolescent rats: Roles of cyclooxygenase-2 and the prostaglandin E2 receptor 1.
Title: Alcohol reinstatement after prolonged abstinence from alcohol drinking by female adolescent rats: Roles of cyclooxygenase-2 and the prostaglandin E(2) receptor 1.
Role of the PGE2 receptor in ischemia-reperfusion injury of the rat retina.
Title: Role of the PGE2 receptor in ischemia-reperfusion injury of the rat retina.
Our study identifies the EP1 signaling pathway as an important link between neuroinflammation and MMP-mediated BBB breakdown in ischemic stroke.
Title: Detrimental role of the EP1 prostanoid receptor in blood-brain barrier damage following experimental ischemic stroke.
A transient interaction between COX-2 and EP1 constitutes a feedback loop whereby an increase in COX-2 expression elevates EP1.
Title: Upregulation of prostaglandin receptor EP1 expression involves its association with cyclooxygenase-2.
Results indicate that EP1 receptor activation during seizures, through a protein kinase C pathway, increases probability of kainic acid induced status epilepticus, and independently promotes hippocampal neurodegeneration and a broad inflammatory response
Title: The prostaglandin EP1 receptor potentiates kainate receptor activation via a protein kinase C pathway and exacerbates status epilepticus.
EP1 deletion exacerbates neuro-behavioral impairments following intracerebral hemorrhage, potentially by slowing down/impairing microglial phagocytosis.
Title: Role of PGE₂ EP1 receptor in intracerebral hemorrhage-induced brain injury.
PGE2 appears to act both as a primary mediator of antigen-induced airway contraction via the EP4 receptor and as a downstream modulator of serotonin-induced bronchoconstriction via the EP1 receptor
Title: Modulation of antigen-induced responses by serotonin and prostaglandin E2 via EP1 and EP4 receptors in the peripheral rat lung.
Results suggest that prostanoid EP(1) receptors are involved in positive regulation of the beating rate.
Title: Prostanoid receptors involved in regulation of the beating rate of neonatal rat cardiomyocytes.
The blockade of EP1 receptor in the ventrolateral periaqueductal grey leads to antinociception in neuropathic pain conditions, despite its down-regulation.
Title: EP1 receptor within the ventrolateral periaqueductal grey controls thermonociception and rostral ventromedial medulla cell activity in healthy and neuropathic rat.
In the trigeminal-vascular system (TVS) we found highest expression of EP(1) and EP(2) protein in the trigeminal nucleus caudalis.
Title: Prostaglandin E2 receptor expression in the rat trigeminal-vascular system and other brain structures involved in pain.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH140664 (e-PCR)
- UniSTS:222732

RH132067 (e-PCR)
- UniSTS:215350

RH143527 (e-PCR)
- UniSTS:232773

PMC209534P1 (e-PCR)
- UniSTS:272001

RH94446 (e-PCR)
- UniSTS:119694

Ptger1 (e-PCR), detects polymorphism
- UniSTS:144290

PMC327192P3 (e-PCR)
- UniSTS:273137

PMC199184P1 (e-PCR)
- UniSTS:271859

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables D1 dopamine receptor binding	ISO Inferred from Sequence Orthology more info
enables prostaglandin E receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables prostaglandin E receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables prostaglandin E receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating dopamine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: prostaglandin E2 receptor EP1 subtype

Names: EP1 prostanoid receptor; PGE receptor, EP1 subtype; PGE2 receptor EP1 subtype; prostaglandin E receptor 1 (subtype EP1); prostaglandin E receptor EP1 subtype; prostanoid EP1 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001278475.1 → NP_001265404.1 prostaglandin E2 receptor EP1 subtype

See identical proteins and their annotated locations for NP_001265404.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/Swiss-Prot

P70597, P97537

UniProtKB/TrEMBL

A6IYD3

Related

ENSRNOP00000005470.1, ENSRNOT00000005470.5

Conserved Domains (1) summary

pfam00001
Location:302 → 354

7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

41374983..41379593 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039097501.2 → XP_038953429.1 prostaglandin E2 receptor EP1 subtype isoform X1

UniProtKB/TrEMBL

A0A8I6A021, A6IYD4

Conserved Domains (2) summary

cd14964
Location:81 → 107

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:80 → 405

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_013100.1: Suppressed sequence

Description

NM_013100.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.