Prkaca protein kinase cAMP-activated catalytic subunit alpha [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Prkacaprovided by RGD
Official Full Name: protein kinase cAMP-activated catalytic subunit alphaprovided by RGD
Primary source: RGD:3389
See related: Ensembl:ENSRNOG00000005257 AllianceGenome:RGD:3389
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: PKCA1; Cs-PKA
Summary: Enables cAMP-dependent protein kinase activity; protein kinase binding activity; and small GTPase binding activity. Involved in several processes, including circadian sleep/wake cycle, REM sleep; regulation of glutamatergic synaptic transmission; and spontaneous exocytosis of neurotransmitter. Located in several cellular components, including Golgi apparatus; perinuclear region of cytoplasm; and presynapse. Part of cAMP-dependent protein kinase complex. Biomarker of brain ischemia. Human ortholog(s) of this gene implicated in adrenal cortical adenoma; congestive heart failure; and primary pigmented nodular adrenocortical disease. Orthologous to human PRKACA (protein kinase cAMP-activated catalytic subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 789.1), Adrenal (RPKM 386.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q11

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (41059843..41083189, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (24155081..24178430, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (25095089..25118869)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Effect and mechanism of Angelic Shaoyaosan mediated AMPK/SIRT1 positive feedback loop to promote autophagy and regulate the systemic inflammatory response in acute pancreatitis.
Title: Effect and mechanism of Angelic Shaoyaosan mediated AMPK/SIRT1 positive feedback loop to promote autophagy and regulate the systemic inflammatory response in acute pancreatitis.
These results suggest that urotensin II induces cardiomyocyte hypertrophy through the cAMP-dependent protein kinase A -mediated upregulation of phospholamban phosphorylation at Ser16, which provides a new experimental foundation for the prevention and/or treatment of cardiac hypertrophy.
Title: Role of PKA in the process of neonatal cardiomyocyte hypertrophy induced by urotensin II.
Using pharmacological and genetic approaches combined with real-time FRET imaging and high resolution microscopy, we demonstrate that in rat cardiac myocytes and other cell types mitochondrial PDE2A2 regulates local cAMP levels and PKA-dependent phosphorylation of Drp1.
Title: PDE2A2 regulates mitochondria morphology and apoptotic cell death via local modulation of cAMP/PKA signalling.
SERCA2a and the PKA/PLN pathway are inhibited by TSH in rat cardiomyocytes
Title: TSH inhibits SERCA2a and the PKA/PLN pathway in rat cardiomyocytes.
inhibition and activation of PKA dramatically affected the phosphorylation state of Ctnnb1 and Gsk3beta, which regulates the differentiation of neural stem cells.
Title: Quantitative Phosphoproteomic Study Reveals that Protein Kinase A Regulates Neural Stem Cell Differentiation Through Phosphorylation of Catenin Beta-1 and Glycogen Synthase Kinase 3β.
This study showed an anti-silicotic effect of db-cAMP that was mediated via PKA/p-CREB/CBP signaling. Furthermore, the findings offer novel insight into the potential use of cAMP signaling for therapeutic strategies to treat silicosis.
Title: Dibutyryl-cAMP attenuates pulmonary fibrosis by blocking myofibroblast differentiation via PKA/CREB/CBP signaling in rats with silicosis.
Ezrin associates with Cx43 (in complex with ZO-1) which places PKA in proximity to Cx43, enabling its phosphorylation and gap junction opening.
Title: A protein kinase A-ezrin complex regulates connexin 43 gap junction communication in liver epithelial cells.
Data suggest Camk2a and Prkaca exhibit substrate specificity that includes phosphorylation of Neto2 at Ser409 in C-terminal domain; Neto2 Ser409 phosphorylation inhibits synaptic targeting of Gluk1. (Camk2a = calcium-calmodulin-dependent protein kinase II, alpha subunit; Prkaca = cAMP-dependent protein kinase, alpha-catalytic subunit; Neto2 = neuropilin and tolloid-like protein 2; Gluk1 = kainate receptor Gluk1)
Title: Phosphorylation of the kainate receptor (KAR) auxiliary subunit Neto2 at serine 409 regulates synaptic targeting of the KAR subunit GluK1.
Findings suggest synaptic and extrasynaptic GABAA alpha4 subunit expression can be modulated by protein kinase A to inform the development of more specific therapeutics for neurological diseases that involve deficits in GABAergic transmission.
Title: Differential regulation of synaptic and extrasynaptic α4 GABA(A) receptor populations by protein kinase A and protein kinase C in cultured cortical neurons.
Our results demonstrate the antifibrotic effect of PTX on radiation-induced lung fibrosis and its effect on modulation of PKA and PAI-1 expression as possible antifibrotic mechanisms.
Title: Pentoxifylline Regulates Plasminogen Activator Inhibitor-1 Expression and Protein Kinase A Phosphorylation in Radiation-Induced Lung Fibrosis.

Submit: New GeneRIF Correction See all GeneRIFs (109)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Prkaca (e-PCR), detects polymorphism
- UniSTS:507174

Prkaca (e-PCR), detects polymorphism
- UniSTS:144189

PMC18620P1 (e-PCR)
- UniSTS:271694

Prkaca (e-PCR), detects polymorphism
- UniSTS:547699

RH128078 (e-PCR)
- UniSTS:211386

Prkaca (e-PCR), detects polymorphism
- UniSTS:507857

RH94810 (e-PCR)
- UniSTS:120056

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables cAMP-dependent protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cAMP-dependent protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables cAMP-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables cAMP-dependent protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables cAMP-dependent protein kinase activity	ISO Inferred from Sequence Orthology more info
enables cAMP-dependent protein kinase activity	TAS Traceable Author Statement more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables manganese ion binding	IEA Inferred from Electronic Annotation more info
enables manganese ion binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein kinase A regulatory subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase A regulatory subunit binding	IC Inferred by Curator more info	PubMed
enables protein kinase A regulatory subunit binding	IEA Inferred from Electronic Annotation more info
enables protein kinase A regulatory subunit binding	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	TAS Traceable Author Statement more info
enables protein serine/threonine/tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine/tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cold	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to cold	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucagon stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to glucagon stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucose stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to heat	IEA Inferred from Electronic Annotation more info
involved_in cellular response to heat	ISO Inferred from Sequence Orthology more info
involved_in cellular response to heat	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to parathyroid hormone stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to parathyroid hormone stimulus	ISO Inferred from Sequence Orthology more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA processing	ISO Inferred from Sequence Orthology more info
involved_in mesoderm formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mesoderm formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of TORC1 signaling	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of TORC1 signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of glycolytic process through fructose-6-phosphate	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of glycolytic process through fructose-6-phosphate	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of meiotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of meiotic cell cycle process involved in oocyte maturation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smoothened signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in neural tube closure	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neural tube closure	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gluconeogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gluconeogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein export from nucleus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of protein export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic modulation of chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in postsynaptic modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in protein export from nucleus	IEA Inferred from Electronic Annotation more info
acts_upstream_of protein export from nucleus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_positive_effect protein export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in protein kinase A signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to lipid droplet	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein localization to lipid droplet	ISO Inferred from Sequence Orthology more info
involved_in regulation of bicellular tight junction assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of bicellular tight junction assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of cellular respiration	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of osteoblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of proteasomal protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of proteasomal protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of protein processing	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic transmission, glutamatergic	IDA Inferred from Direct Assay more info	PubMed
involved_in sperm capacitation	IEA Inferred from Electronic Annotation more info
involved_in sperm capacitation	ISO Inferred from Sequence Orthology more info
involved_in spontaneous exocytosis of neurotransmitter	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in acrosomal vesicle	IEA Inferred from Electronic Annotation more info
located_in acrosomal vesicle	ISO Inferred from Sequence Orthology more info
located_in acrosomal vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in axoneme	IEA Inferred from Electronic Annotation more info
located_in axoneme	ISO Inferred from Sequence Orthology more info
part_of cAMP-dependent protein kinase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cAMP-dependent protein kinase complex	IDA Inferred from Direct Assay more info	PubMed
part_of cAMP-dependent protein kinase complex	IEA Inferred from Electronic Annotation more info
part_of cAMP-dependent protein kinase complex	ISO Inferred from Sequence Orthology more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in ciliary base	IEA Inferred from Electronic Annotation more info
located_in ciliary base	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
located_in germinal vesicle	ISO Inferred from Sequence Orthology more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
is_active_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
located_in neuromuscular junction	IEA Inferred from Electronic Annotation more info
located_in neuromuscular junction	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
part_of nucleotide-activated protein kinase complex	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane raft	IEA Inferred from Electronic Annotation more info
located_in plasma membrane raft	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed
located_in presynapse	IMP Inferred from Mutant Phenotype more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
located_in sperm flagellum	IEA Inferred from Electronic Annotation more info
located_in sperm flagellum	ISO Inferred from Sequence Orthology more info
located_in sperm flagellum	ISS Inferred from Sequence or Structural Similarity more info
located_in sperm midpiece	ISO Inferred from Sequence Orthology more info
located_in sperm midpiece	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: cAMP-dependent protein kinase catalytic subunit alpha

Names: PKA C-alpha; cAMP-dependent protein kinase catalytic subunit C alpha; protein kinase A; protein kinase, cAMP-dependent, alpha catalytic subunit; protein kinase, cAMP-dependent, catalytic, alpha

NP_001094392.1

EC 2.7.11.11

XP_006255281.1

EC 2.7.11.11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100922.2 → NP_001094392.1 cAMP-dependent protein kinase catalytic subunit alpha

See identical proteins and their annotated locations for NP_001094392.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000019

UniProtKB/Swiss-Prot

P27791, Q6UA68

UniProtKB/TrEMBL

A1L1M0, F7F4Z7

Related

ENSRNOP00000044732.3, ENSRNOT00000041717.5

Conserved Domains (2) summary

PTZ00426
Location:16 → 334

PTZ00426; cAMP-dependent protein kinase catalytic subunit; Provisional

cd14209
Location:42 → 331

STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

41059843..41083189 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006255219.4 → XP_006255281.1 cAMP-dependent protein kinase catalytic subunit alpha isoform X1

UniProtKB/Swiss-Prot

P27791, Q6UA68

UniProtKB/TrEMBL

A0A8I6AD31

Related

ENSRNOP00000086764.1

Conserved Domains (2) summary

PTZ00426
Location:8 → 326

PTZ00426; cAMP-dependent protein kinase catalytic subunit; Provisional

cd14209
Location:34 → 323

STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase