U.S. flag

An official website of the United States government

G6pc1 glucose-6-phosphatase catalytic subunit 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25634, updated on 4-Jan-2025

Summary

Symbol
G6pc1provided by RGD
Full Name
glucose-6-phosphatase catalytic subunit 1provided by RGD
Primary source
RGD:2644
See related
EnsemblRapid:ENSRNOG00000053448 AllianceGenome:RGD:2644
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
G6pc; Psme3; G6Pase
Summary
Enables glucose-6-phosphatase activity. Involved in several processes, including cellular response to insulin stimulus; gluconeogenesis; and response to resveratrol. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of proteasome activator complex. Predicted to be active in endoplasmic reticulum and membrane. Used to study type 2 diabetes mellitus. Biomarker of steatotic liver disease. Human ortholog(s) of this gene implicated in glycogen storage disease Ia and hepatocellular carcinoma. Orthologous to human G6PC1 (glucose-6-phosphatase catalytic subunit 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Kidney (RPKM 1591.1) and Liver (RPKM 1555.8) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See G6pc1 in Genome Data Viewer
Location:
10q31
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (86807659..86819023)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (86307400..86318766)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (89286009..89296213)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene amine oxidase, copper containing 3 Neighboring gene uncharacterized LOC134480877 Neighboring gene U1 spliceosomal RNA Neighboring gene alanyl-tRNA synthetase domain containing 1 Neighboring gene prostaglandin E synthase 3 like

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Clone Names

  • MGC93613, AC123346.1

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables copper ion binding  
enables glucose-6-phosphatase activity  
enables glucose-6-phosphatase activity PubMed 
enables glucose-6-phosphatase activity  
enables glucose-6-phosphatase activity  
enables glucose-6-phosphatase activity PubMed 
enables phosphate ion binding  
enables phosphotransferase activity, alcohol group as acceptor  
enables primary methylamine oxidase activity  
enables quinone binding  
Items 1 - 25 of 27
Process Evidence Code Pubs
involved_in amine metabolic process  
involved_in cellular response to insulin stimulus PubMed 
acts_upstream_of_or_within cholesterol homeostasis  
involved_in gluconeogenesis  
involved_in gluconeogenesis PubMed 
involved_in gluconeogenesis  
involved_in gluconeogenesis  
involved_in gluconeogenesis PubMed 
involved_in glucose 6-phosphate metabolic process  
involved_in glucose 6-phosphate metabolic process PubMed 
acts_upstream_of_or_within glucose 6-phosphate metabolic process  
acts_upstream_of_or_within glucose homeostasis  
involved_in glucose homeostasis  
acts_upstream_of_or_within glucose-6-phosphate transport  
acts_upstream_of_or_within glycogen catabolic process  
acts_upstream_of_or_within glycogen metabolic process  
involved_in lipid homeostasis PubMed 
acts_upstream_of_or_within multicellular organism growth  
acts_upstream_of_or_within regulation of gene expression  
involved_in response to carbohydrate PubMed 
involved_in response to food PubMed 
involved_in response to insulin PubMed 
involved_in response to nutrient levels PubMed 
involved_in response to resveratrol PubMed 
acts_upstream_of_or_within steroid metabolic process  
acts_upstream_of_or_within triglyceride metabolic process  
acts_upstream_of_or_within urate metabolic process  
Items 1 - 25 of 27
Component Evidence Code Pubs
is_active_in endoplasmic reticulum  
located_in endoplasmic reticulum  
located_in endoplasmic reticulum membrane  
is_active_in membrane  
located_in membrane  
located_in membrane  
part_of proteasome activator complex  

General protein information

Preferred Names
glucose-6-phosphatase catalytic subunit 1
Names
G-6-Pase
glucose-6-phosphatase, catalytic subunit
proteasome activator subunit 3
NP_037230.2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013098.2NP_037230.2  glucose-6-phosphatase catalytic subunit 1

    See identical proteins and their annotated locations for NP_037230.2

    Status: VALIDATED

    Source sequence(s)
    BC090067
    UniProtKB/Swiss-Prot
    P43428, Q5FVC9
    UniProtKB/TrEMBL
    A0A8L2QF08, A6HJB1
    Related
    ENSRNOP00000071453.1, ENSRNOT00000085831.3
    Conserved Domains (1) summary
    cd03381
    Location:42280
    PAP2_glucose_6_phosphatase; PAP2_like proteins, glucose-6-phosphatase subfamily. Glucose-6-phosphatase converts glucose-6-phosphate into free glucose and is active in the lumen of the endoplasmic reticulum, where it is bound to the membrane. The generation of free glucose is an ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    86807659..86819023
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
External link. Please review our privacy policy.