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Plin1 perilipin 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25629, updated on 13-Apr-2024

Summary

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Official Symbol
Plin1provided by RGD
Official Full Name
perilipin 1provided by RGD
Primary source
RGD:3351
See related
Ensembl:ENSRNOG00000015086 AllianceGenome:RGD:3351
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Plin; PERIA
Summary
Predicted to be involved in negative regulation of lipid catabolic process. Predicted to act upstream of or within cellular response to cold and lipid catabolic process. Located in lipid droplet. Human ortholog(s) of this gene implicated in familial partial lipodystrophy type 4 and obesity. Orthologous to human PLIN1 (perilipin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 331.7), Thymus (RPKM 302.0) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1q31
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (143073612..143086199, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (133664294..133676854, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (141458907..141470927, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene kinesin family member 7 Neighboring gene peptidyl-prolyl cis-trans isomerase NIMA-interacting 4-like Neighboring gene uncharacterized LOC120099868 Neighboring gene peroxisomal biogenesis factor 11 alpha Neighboring gene WD repeat domain 93 Neighboring gene small nuclear ribonucleoprotein polypeptide E like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Serum amyloid A induces lipolysis by downregulating perilipin through ERK1/2 and PKA signaling pathways. Liu LR, et al. Obesity (Silver Spring), 2011 Dec. PMID 21701568
  2. Isolation of cDNAs for perilipins A and B: sequence and expression of lipid droplet-associated proteins of adipocytes. Greenberg AS, et al. Proc Natl Acad Sci U S A, 1993 Dec 15. PMID 7505452, Free PMC Article
  3. Heat shock protein 70 is translocated to lipid droplets in rat adipocytes upon heat stimulation. Jiang H, et al. Biochim Biophys Acta, 2007 Jan. PMID 17175194
  4. Obese subjects carrying the 11482G>A polymorphism at the perilipin locus are resistant to weight loss after dietary energy restriction. Corella D, et al. J Clin Endocrinol Metab, 2005 Sep. PMID 15985482
  5. Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity. Tansey JT, et al. Proc Natl Acad Sci U S A, 2001 May 22. PMID 11371650, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. evidence is presented for perilipin expression in rat, mouse, and human islets of Langerhans
    Title: Perilipin is present in islets of Langerhans and protects against lipotoxicity when overexpressed in the beta-cell line INS-1.
  2. perilipin interacts with CGI-58 and is localized to lipid droplets
    Title: CGI-58 interacts with perilipin and is localized to lipid droplets. Possible involvement of CGI-58 mislocalization in Chanarin-Dorfman syndrome.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in cellular response to cold IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to cold ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of lipid catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell periphery ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in lipid droplet IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lipid droplet IEA
Inferred from Electronic Annotation
more info
  
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
  
located_in lipid droplet TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
perilipin-1
Names
PERI
lipid droplet-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308145.1 → NP_001295074.1  perilipin-1

    See identical proteins and their annotated locations for NP_001295074.1

    Status: VALIDATED

    Source sequence(s)
    BU671441, FM042626, FM044716, JAXUCZ010000001
    UniProtKB/Swiss-Prot
    P43884
    UniProtKB/TrEMBL
    A6JC64, F1LSF5
    Related
    ENSRNOP00000061809.4, ENSRNOT00000065759.4
    Conserved Domains (1) summary
    pfam03036
    Location:14 → 392
    Perilipin; Perilipin family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    143073612..143086199 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008759499.4 → XP_008757721.1  perilipin-1 isoform X1

    See identical proteins and their annotated locations for XP_008757721.1

    UniProtKB/Swiss-Prot
    P43884
    UniProtKB/TrEMBL
    A6JC64, F1LSF5
    Conserved Domains (1) summary
    pfam03036
    Location:14 → 392
    Perilipin; Perilipin family

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_013094.1: Suppressed sequence

    Description
    NM_013094.1: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43884.1 GenPept UniProtKB/Swiss-Prot:P43884

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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