Plau plasminogen activator, urokinase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Plauprovided by RGD
Official Full Name: plasminogen activator, urokinaseprovided by RGD
Primary source: RGD:3343
See related: Ensembl:ENSRNOG00000010516 AllianceGenome:RGD:3343
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: UPAM
Summary: Enables peptidase activity. Involved in several processes, including cellular response to hepatocyte growth factor stimulus; cellular response to staurosporine; and positive regulation of ovulation. Located in extracellular space and membrane. Used to study several diseases, including alcoholic liver cirrhosis; lung disease (multiple); sciatic neuropathy; status epilepticus; and transient cerebral ischemia. Biomarker of brain disease (multiple); end stage renal disease; myocardial infarction; sciatic neuropathy; and thrombosis. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease (multiple); Quebec platelet disorder; end stage renal disease; lung disease (multiple); and mitral valve prolapse. Orthologous to human PLAU (plasminogen activator, urokinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 2347.6), Muscle (RPKM 197.9) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 15p16

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (3505485..3511987, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (3456230..3462732, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (3644296..3650765, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transcriptional activation and regulation of urokinase plasminogen activator inducted by LPS through MyD88 independent pathway in rat Sertoli cells.
Title: Transcriptional activation and regulation of urokinase plasminogen activator inducted by LPS through MyD88 independent pathway in rat Sertoli cells.
that study shows that urokinase attenuates pulmonary thromboembolism in an animal model by inhibition of inflammatory response
Title: Urokinase Attenuates Pulmonary Thromboembolism in an Animal Model by Inhibition of Inflammatory Response.
autophagy could regulate the EPCs migration through mTOR-P70 S6K pathway, and MMP2, MMP9 and uPA may also involve in the regulation mechanism
Title: Autophagy inhibits endothelial progenitor cells migration via the regulation of MMP2, MMP9 and uPA under normoxia condition.
The effects of UPA/UPAR on migration of lipid-loaded cells occurred through the binding to LRP-1.
Title: UPA promotes lipid-loaded vascular smooth muscle cell migration through LRP-1.
uPA and uPAR expressions were significantly increased both at transcriptional and protein level during early phase post myocardial infarct period
Title: uPA, uPAR and TGFβ₁ expression during early and late post myocardial infarction period in rat myocardium.
Expression of u-PA/PAI-1 mRNA and protein increased during the early stage of hyperoxic exposure and decreased during the middle and late stage.
Title: [Changes of u-PA and PAI-1 expression in the lung tissue of neonatal rats after inhaling high concentration oxygen].
High glucose decreased the expressions of tPA and uPA, and increased PAI1. Losartan could partly reverse partly this expression.
Title: [Effects of losartan on expressions of plasminogen activator and plasminogen activator inhibitor-1 of rat proximal tubular epithelial cells cultured with high glucose].
Data show that Huangqi is able to stimulate expression of cyclin D1 and excite ERK and P38 MAPK signaling pathways to promote cell proliferation and stimulates the FGF-2-UPA-MMP 9 migration pathway and cell migration.
Title: The proliferation and migration effects of huangqi on RSC96 Schwann cells.
Transplantation of Plau gene-modified bone marrow-derived liver stem cells reduces liver fibrosis.
Title: Transplantation of urokinase-type plasminogen activator gene-modified bone marrow-derived liver stem cells reduces liver fibrosis in rats.
PAI-1 plays a role in the occurrence of liver failure after excessive hepatectomy via accelerated maturation of pro-uPA and fibrinolytic factors.
Title: PAI-1 plays an important role in liver failure after excessive hepatectomy in the rat.

Submit: New GeneRIF Correction See all GeneRIFs (20)

General gene information

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Markers

Plau (e-PCR), detects polymorphism
- UniSTS:507149

RH94858 (e-PCR)
- UniSTS:120104

RH94873 (e-PCR)
- UniSTS:120119

RH136861 (e-PCR)
- UniSTS:218950

AU048556 (e-PCR)
- UniSTS:145006

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to fluid shear stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to glucose stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to hepatocyte growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to organic substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to staurosporine	IEP Inferred from Expression Pattern more info	PubMed
involved_in embryo implantation	IEP Inferred from Expression Pattern more info	PubMed
involved_in fibrinolysis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within fibrinolysis	ISO Inferred from Sequence Orthology more info
involved_in plasminogen activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in plasminogen activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of reactive oxygen species metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of smooth muscle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of hepatocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of smooth muscle cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in response to activity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hepatocyte growth factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hyperoxia	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle tissue regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of protein complex involved in cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
part_of serine protease inhibitor complex	ISO Inferred from Sequence Orthology more info
part_of serine-type endopeptidase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: urokinase-type plasminogen activator

Names: U-plasminogen activator; Urinary plasminogen activator, urokinase; uPA; urokinase plasminogen activator

NP_037217.3

EC 3.4.21.73

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013085.3 → NP_037217.3 urokinase-type plasminogen activator precursor

See identical proteins and their annotated locations for NP_037217.3

Status: PROVISIONAL

Source sequence(s)

BC105859

UniProtKB/Swiss-Prot

P29598, Q6LBK5

UniProtKB/TrEMBL

A6KKR2, F7F966, Q3KR76

Related

ENSRNOP00000014273.3, ENSRNOT00000014273.6

Conserved Domains (3) summary

smart00020
Location:178 → 420

Tryp_SPc; Trypsin-like serine protease

cd00108
Location:67 → 152

KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...

cd00190
Location:179 → 423

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...