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Ube2i ubiquitin-conjugating enzyme E2I [ Rattus norvegicus (Norway rat) ]

Gene ID: 25573, updated on 11-Apr-2024

Summary

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Official Symbol
Ube2iprovided by RGD
Official Full Name
ubiquitin-conjugating enzyme E2Iprovided by RGD
Primary source
RGD:3926
See related
Ensembl:ENSRNOG00000066579 AllianceGenome:RGD:3926
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ubc9; UbcE2A
Summary
Enables bHLH transcription factor binding activity; protein C-terminus binding activity; and ubiquitin-like protein transferase activity. Involved in cellular protein metabolic process; positive regulation of DNA-binding transcription factor activity; and regulation of signal transduction. Located in dendrite; nucleus; and synapse. Orthologous to human UBE2I (ubiquitin conjugating enzyme E2 I). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 383.0), Spleen (RPKM 264.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
10q12
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (14782245..14802911, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (14277749..14294681, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (14618615..14639274, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene TSR3 ribosome maturation factor Neighboring gene BAI1-associated protein 3 Neighboring gene microRNA 3547 Neighboring gene protease, serine, 34 Neighboring gene small nucleolar RNA SNORA70

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Developmental regulation of Ubc9 in the rat nervous system. Watanabe M, et al. Acta Biochim Pol, 2008. PMID 19039338
  2. Characterization of a new SUMO-1 nuclear body (SNB) enriched in pCREB, CBP, c-Jun in neuron-like UR61 cells. Navascués J, et al. Chromosoma, 2007 Oct. PMID 17549507
  3. Involvement of ubiquitination and sumoylation in bladder lesions induced by persistent long-term low dose ionizing radiation in humans. Romanenko AM, et al. J Urol, 2006 Feb. PMID 16407042
  4. Expression level of Ubc9 protein in rat tissues. Gołebiowski F, et al. Acta Biochim Pol, 2003. PMID 14739995
  5. A role for Ubc9 in tumorigenesis. Mo YY, et al. Oncogene, 2005 Apr 14. PMID 15735760

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. UBC9 regulates Nav1.5 expression levels in a SUMOylation-independent manner.
    Title: UBC9 regulates cardiac sodium channel Na(v)1.5 ubiquitination, degradation and sodium current density.
  2. ISH analysis revealed expression of Ubc9 was high in neuronal stem cells and moderate in differentiated neurons at embryonic stages but in adult brain, moderate expression was observed in dentate granular neurons and pyramidal neurons
    Title: Developmental regulation of Ubc9 in the rat nervous system.
  3. Immunohistochemistry showed that Ubc9 and PIAS1 are markedly expressed in rat adrenal glomerulosa cells
    Title: Ubc9 and Protein Inhibitor of Activated STAT 1 Activate Chicken Ovalbumin Upstream Promoter-Transcription Factor I-mediated Human CYP11B2 Gene Transcription.
  4. Glucocorticoid receptor ligand binding domain is sufficient for the modulation of glucocorticoid induction properties by homologous receptors, coactivator transcription intermediary factor 2, and Ubc9
    Title: Glucocorticoid receptor ligand binding domain is sufficient for the modulation of glucocorticoid induction properties by homologous receptors, coactivator transcription intermediary factor 2, and Ubc9.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC105476

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables HLH domain binding ISO
Inferred from Sequence Orthology
more info
  
enables RING-like zinc finger domain binding ISO
Inferred from Sequence Orthology
more info
  
enables SUMO conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SUMO conjugating enzyme activity ISO
Inferred from Sequence Orthology
more info
  
enables SUMO transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables SUMO transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables bHLH transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables ionotropic glutamate receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small protein activating enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription coregulator binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear export ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of intracellular steroid hormone receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein sumoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein sumoylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein sumoylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein sumoylation ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in PML body ISO
Inferred from Sequence Orthology
more info
  
part_of SUMO ligase complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in fibrillar center IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transferase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
SUMO-conjugating enzyme UBC9
Names
RING-type E3 SUMO transferase UBC9
SUMO-protein ligase
Ubiquitin conjugating enzyme E2I (homologous to yeast UBC9)
ubiquitin carrier protein 9
ubiquitin carrier protein I
ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)
ubiquitin-conjugating enzyme UbcE2A
ubiquitin-protein ligase I
NP_037182.1
XP_006245981.1
XP_006245982.1
XP_008765771.3
XP_017452533.1
XP_063124544.1
XP_063124546.1
XP_063124547.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001428972.1 → NP_001415901.1  SUMO-conjugating enzyme UBC9 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010

  2. NM_001428973.1 → NP_001415902.1  SUMO-conjugating enzyme UBC9 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010

  3. NM_001428974.1 → NP_001415903.1  SUMO-conjugating enzyme UBC9 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010

  4. NM_001428975.1 → NP_001415904.1  SUMO-conjugating enzyme UBC9 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010

  5. NM_001428976.1 → NP_001415905.1  SUMO-conjugating enzyme UBC9 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010

  6. NM_013050.3 → NP_037182.1  SUMO-conjugating enzyme UBC9 isoform 1

    See identical proteins and their annotated locations for NP_037182.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    P63281
    UniProtKB/TrEMBL
    A6HD16
    Related
    ENSRNOP00000085922.1, ENSRNOT00000104064.1
    Conserved Domains (1) summary
    pfam00179
    Location:8 → 152
    UQ_con; Ubiquitin-conjugating enzyme

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    14782245..14802911 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063268476.1 → XP_063124546.1  SUMO-conjugating enzyme UBC9 isoform X3

  2. XM_063268474.1 → XP_063124544.1  SUMO-conjugating enzyme UBC9 isoform X2

  3. XM_008767549.4 → XP_008765771.3  SUMO-conjugating enzyme UBC9 isoform X1

    UniProtKB/TrEMBL
    A0A0G2KB55

  4. XM_006245920.5 → XP_006245982.1  SUMO-conjugating enzyme UBC9 isoform X4

    UniProtKB/Swiss-Prot
    P63281
    UniProtKB/TrEMBL
    A6HD16
    Conserved Domains (1) summary
    pfam00179
    Location:8 → 152
    UQ_con; Ubiquitin-conjugating enzyme

  5. XM_017597044.3 → XP_017452533.1  SUMO-conjugating enzyme UBC9 isoform X4

    UniProtKB/Swiss-Prot
    P63281
    UniProtKB/TrEMBL
    A6HD16
    Conserved Domains (1) summary
    pfam00179
    Location:8 → 152
    UQ_con; Ubiquitin-conjugating enzyme

  6. XM_063268477.1 → XP_063124547.1  SUMO-conjugating enzyme UBC9 isoform X5

  7. XM_006245919.5 → XP_006245981.1  SUMO-conjugating enzyme UBC9 isoform X4

    UniProtKB/Swiss-Prot
    P63281
    UniProtKB/TrEMBL
    A6HD16
    Conserved Domains (1) summary
    pfam00179
    Location:8 → 152
    UQ_con; Ubiquitin-conjugating enzyme
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P63281.1 GenPept UniProtKB/Swiss-Prot:P63281

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