Sstr4 somatostatin receptor 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sstr4provided by RGD
Official Full Name: somatostatin receptor 4provided by RGD
Primary source: RGD:3764
See related: Ensembl:ENSRNOG00000004641 AllianceGenome:RGD:3764
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Smstr4
Summary: Enables somatostatin receptor activity. Involved in several processes, including cellular response to glucocorticoid stimulus; positive regulation of arachidonic acid secretion; and regulation of signal transduction. Located in cytoplasm and plasma membrane. Biomarker of status epilepticus. Orthologous to human SSTR4 (somatostatin receptor 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: 3q41

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (156307992..156309855)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (135854826..135856689)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (142739781..142741644)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

There is an increase in sst4 and sst2 expression in the habenula, following imipramine administration in a chronic stress model.
Title: Behavioral response to imipramine under chronic mild stress corresponds with increase of mRNA encoding somatostatin receptors sst2 and sst4 expression in medial habenular nucleus.
All SSTR1-5 proteins were observed at embryonal day 10 and increased with time in major structures, but the localization varied between the different subtypes. SSTR3-4 was co-localized with insulin and pancreatic polypeptide.
Title: Somatostatin receptor 1-5; expression profiles during rat development.
sstr4 activation modulates G-protein coupled inward rectifying potassium channels and voltage stimulated calcium signals in dorsal root ganglion neurons, mechanisms thought to contribute to the analgesic propoerties sstr4 agonists
Title: Somatostatin 4 receptor activation modulates G-protein coupled inward rectifying potassium channels and voltage stimulated calcium signals in dorsal root ganglion neurons.
Activity-regulated somatostatin expression reduces dendritic spine density and lowers excitatory synaptic transmission via postsynaptic somatostatin receptor 4
Title: Activity-regulated somatostatin expression reduces dendritic spine density and lowers excitatory synaptic transmission via postsynaptic somatostatin receptor 4.
Somatostatin stimulates the migration of hepatic oval cells within injured liver through SSTR4, and this action appears to be mediated by the PI3K pathway.
Title: Somatostatin stimulates the migration of hepatic oval cells in the injured rat liver.
Somatostatin receptor subtype 4 is expressed specifically in retinal ganglion cells. Action potentials are reduced during inhibition.
Title: Modulation of voltage-gated ion channels in rat retinal ganglion cells mediated by somatostatin receptor subtype 4.
All five SSTR are expressed in splanchnic blood vessels in normal and cirrhotic rats.
Title: Expression of somatostatin receptors in splanchnic blood vessels of normal and cirrhotic rats.
There is a positive role for SST in the migration of HOCs, and that this effect is mediated through SSTR4.
Title: A potential role of somatostatin and its receptor SSTR4 in the migration of hepatic oval cells.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables neuropeptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables somatostatin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables somatostatin receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to glucocorticoid stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to glucocorticoid stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in forebrain development	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of arachidonic acid secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in somatostatin signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: somatostatin receptor type 4

Names: SS-4-R; SS4-R; SS4R; Somatostatin receptor subtype 4 Rattus norvegicus Sprague-Dawley major hippocampal somatostatin receptor (SSTR4) mRNA

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013036.3 → NP_037168.1 somatostatin receptor type 4

See identical proteins and their annotated locations for NP_037168.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

P30937

UniProtKB/TrEMBL

A6K7B6

Related

ENSRNOP00000066231.1, ENSRNOT00000006181.7

Conserved Domains (2) summary

pfam00001
Location:60 → 307

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:52 → 283

7tm_4; Olfactory receptor