U.S. flag

An official website of the United States government

Slc5a1 solute carrier family 5 member 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25552, updated on 4-Jan-2025

Summary

Official Symbol
Slc5a1provided by RGD
Official Full Name
solute carrier family 5 member 1provided by RGD
Primary source
RGD:3713
See related
EnsemblRapid:ENSRNOG00000017775 AllianceGenome:RGD:3713
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
SGLT1; SGLT1a
Summary
Enables D-glucose:sodium symporter activity. Predicted to be involved in several processes, including D-glucose transmembrane transport; alpha-glucoside transport; and intestinal D-glucose absorption. Predicted to act upstream of or within D-glucose transmembrane transport; intestinal absorption; and metanephros development. Located in apical plasma membrane; brush border membrane; and cell-cell junction. Human ortholog(s) of this gene implicated in glucose-galactose malabsorption. Orthologous to human SLC5A1 (solute carrier family 5 member 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Kidney (RPKM 121.6) and Lung (RPKM 51.7) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Slc5a1 in Genome Data Viewer
Location:
14q21
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (81778495..81843084, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (77553990..77618589, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (82910448..82975303, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene C-terminal binding protein 1 Neighboring gene spondin 2 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Clone Names

  • MGC93553

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in D-glucose import across plasma membrane  
acts_upstream_of_or_within D-glucose transmembrane transport  
involved_in D-glucose transmembrane transport  
involved_in D-glucose transmembrane transport PubMed 
involved_in alpha-glucoside transport  
NOT involved_in chloride transmembrane transport  
involved_in galactose transmembrane transport  
involved_in intestinal D-glucose absorption  
involved_in intestinal D-glucose absorption  
involved_in intestinal D-glucose absorption PubMed 
acts_upstream_of_or_within intestinal absorption  
involved_in intestinal absorption PubMed 
acts_upstream_of_or_within metanephros development  
involved_in regulation of transporter activity  
involved_in renal D-glucose absorption  
involved_in renal D-glucose absorption  
involved_in sodium ion import across plasma membrane  
involved_in sodium ion transport  
involved_in sodium ion transport  
involved_in transepithelial water transport  
involved_in transmembrane transport  
involved_in transport across blood-brain barrier  
Component Evidence Code Pubs
located_in apical plasma membrane PubMed 
located_in apical plasma membrane  
located_in apical plasma membrane  
located_in basolateral plasma membrane PubMed 
located_in brush border  
located_in brush border membrane PubMed 
located_in cell-cell junction PubMed 
located_in early endosome  
located_in perinuclear region of cytoplasm  
is_active_in plasma membrane  
located_in plasma membrane  

General protein information

Preferred Names
sodium/glucose cotransporter 1
Names
Na(+)/glucose cotransporter 1
Solute carrier family 5, member alpha 1 (Na+/glucose cotransporter)
high affinity sodium-glucose cotransporter
solute carrier family 5 (sodium/glucose cotransporter), member 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013033.2NP_037165.1  sodium/glucose cotransporter 1

    See identical proteins and their annotated locations for NP_037165.1

    Status: PROVISIONAL

    Source sequence(s)
    D16101
    UniProtKB/Swiss-Prot
    P53790, P97787
    UniProtKB/TrEMBL
    A6IK69, A6IK70
    Related
    ENSRNOP00000024165.5, ENSRNOT00000024165.8
    Conserved Domains (1) summary
    cl00456
    Location:27665
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    81778495..81843084 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
External link. Please review our privacy policy.