Ptgds prostaglandin D2 synthase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ptgdsprovided by RGD
Official Full Name: prostaglandin D2 synthaseprovided by RGD
Primary source: RGD:3433
See related: Ensembl:ENSRNOG00000015550 AllianceGenome:RGD:3433
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: PH2DISO
Summary: Enables prostaglandin-D synthase activity and retinoid binding activity. Involved in prostaglandin biosynthetic process and response to glucocorticoid. Located in Golgi apparatus and extracellular space. Biomarker of sensorineural hearing loss and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in carotid artery disease. Orthologous to human PTGDS (prostaglandin D2 synthase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 3126.9) See more
Orthologs: human mouse all
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Genomic context

Location:: 3p13

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (28680044..28682978, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (8281899..8284833, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (2686125..2689059, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ER-depletion lowering the 'hypothalamus-uterus-kidney' axis functions by perturbing the renal ERbeta/Ptgds signalling pathway.
Title: ER-depletion lowering the 'hypothalamus-uterus-kidney' axis functions by perturbing the renal ERβ/Ptgds signalling pathway.
HIF-1alpha-l-PGDS-PPARgamma regulates hypoxia-induced ANP secretion in beating rat atria
Title: HIF-1α-l-PGDS-PPARγ regulates hypoxia-induced ANP secretion in beating rat atria.
Lipocalin-type prostaglandin synthase (L-PGDS) may have a role in sleep and chronic intermittent hypoxia
Title: The significant effect of chronic intermittent hypoxia on prostaglandin D(2) biosynthesis in rat brain.
Anorectic tumor-bearing rats do not display the changes in ventral striatal prostaglandin D synthase expression observed in food-restricted weight-matched animals.
Title: Hormonal, hypothalamic and striatal responses to reduced body weight gain are attenuated in anorectic rats bearing small tumors.
This cardioprotective effect of dexamethasone was markedly reduced in L-PGDS-deficient mice
Title: Glucocorticoid protects rodent hearts from ischemia/reperfusion injury by activating lipocalin-type prostaglandin D synthase-derived PGD2 biosynthesis.
These results suggested that the removal of the disulfide bond slightly increased the affinities of L-PGDS for ligand binding by changing the hydrophobic regions.
Title: Effects of removing a conserved disulfide bond on the biological characteristics of rat lipocalin-type prostaglandin D synthase.
L-PGDS, via production of prostaglandin D(2), is an important mediator of muscle and adipose glucose transport which is modulated by glycemic conditions and plays a significant role in the glucose intolerance associated with type 2 diabetes
Title: Lipocalin-type prostaglandin D(2) synthase stimulates glucose transport via enhanced GLUT4 translocation.
Prostaglandin D synthase and prostacyclin synthase are present and could be regulated by steroids in the rat uterus during pregnancy. Endometrium could be significant source of PGD(2) and PGI(2) at specific times during pregnancy.
Title: Regulation of prostaglandin D synthase and prostacyclin synthase in the endometrium of cyclic, pregnant, and pseudopregnant rats and their regulation by sex steroids.
study showed that L-PGDS was strikingly expressed in the caput epididymidis, while a moderate to weak expression was observed in the corpus and cauda epididymidis
Title: Different expression of lipocalin-type prostaglandin D synthase in rat epididymidis.
Gene expression is regulated by Hes-1 through E-box and interleukin-1 beta via two NF-kappa B elements in rat leptomeningeal cells.
Title: Regulation of lipocalin-type prostaglandin D synthase gene expression by Hes-1 through E-box and interleukin-1 beta via two NF-kappa B elements in rat leptomeningeal cells.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables fatty acid binding	ISO Inferred from Sequence Orthology more info
enables prostaglandin-D synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables prostaglandin-D synthase activity	ISO Inferred from Sequence Orthology more info
enables retinoid binding	IDA Inferred from Direct Assay more info	PubMed
enables retinoid binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in gene expression	ISO Inferred from Sequence Orthology more info
involved_in mast cell degranulation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of male germ cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in prostaglandin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of circadian sleep/wake cycle, sleep	ISO Inferred from Sequence Orthology more info
involved_in regulation of circadian sleep/wake cycle, sleep	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	NAS Non-traceable Author Statement more info	PubMed
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in rough endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in rough endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: prostaglandin-H2 D-isomerase

Names: PGD2 synthase; PGDS; PGDS2; Prostaglandin D synthase; glutathione-independent PGD synthase; glutathione-independent PGD synthetase; lipocalin-type prostaglandin-D synthase; prostaglandin D2 synthase (brain)

NP_037147.1

EC 5.3.99.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013015.2 → NP_037147.1 prostaglandin-H2 D-isomerase precursor

See identical proteins and their annotated locations for NP_037147.1

Status: PROVISIONAL

Source sequence(s)

J04488

UniProtKB/Swiss-Prot

P22057

UniProtKB/TrEMBL

A6JT70

Related

ENSRNOP00000020926.4, ENSRNOT00000020926.6

Conserved Domains (1) summary

cl10502
Location:30 → 188

lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family