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Prkar1b protein kinase cAMP-dependent type I regulatory subunit beta [ Rattus norvegicus (Norway rat) ]

Gene ID: 25521, updated on 13-Apr-2024

Summary

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Official Symbol
Prkar1bprovided by RGD
Official Full Name
protein kinase cAMP-dependent type I regulatory subunit betaprovided by RGD
Primary source
RGD:3392
See related
Ensembl:ENSRNOG00000028733 AllianceGenome:RGD:3392
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RIbeta; RGD1563094
Summary
Enables cAMP binding activity and cAMP-dependent protein kinase regulator activity. Involved in several processes, including positive regulation of fear response; positive regulation of long-term synaptic potentiation; and regulation of nervous system process. Located in cytoplasm. Part of cAMP-dependent protein kinase complex. Orthologous to human PRKAR1B (protein kinase cAMP-dependent type I regulatory subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 433.8), Testes (RPKM 43.4) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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Location:
12q11
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (20606066..20738766)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (15492233..15624942)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (17614536..17713567)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene guided entry of tail-anchored proteins factor 4 Neighboring gene uncharacterized LOC102547493 Neighboring gene Sad1 and UNC84 domain containing 1 Neighboring gene dynein, axonemal, assembly factor 5 Neighboring gene uncharacterized LOC103691050 Neighboring gene uncharacterized LOC134481161 Neighboring gene platelet derived growth factor subunit A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Deficiency of the RIβ subunit of protein kinase A causes body tremor and impaired fear conditioning memory in rats. Hoang Trung H, et al. Sci Rep, 2021 Jan 21. PMID 33479380, Free PMC Article
  2. Rat RI beta isoform of type I regulatory subunit of cyclic adenosine monophosphate-dependent protein kinase: cDNA sequence analysis, mRNA tissue specificity, and rat/mouse difference in expression in testis. Massa JS, et al. Mol Reprod Dev, 1990 Jun. PMID 2372396
  3. Clustered distribution of cAMP-dependent protein kinase regulatory isoform RI alpha during the development of the rat brain. Mucignat-Caretta C, et al. J Comp Neurol, 2002 Sep 30. PMID 12210127
  4. Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory. Abel T, et al. Cell, 1997 Mar 7. PMID 9054501
  5. Hippocampal long-term depression and depotentiation are defective in mice carrying a targeted disruption of the gene encoding the RI beta subunit of cAMP-dependent protein kinase. Brandon EP, et al. Proc Natl Acad Sci U S A, 1995 Sep 12. PMID 7568030, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deficiency of the RIbeta subunit of protein kinase A causes body tremor and impaired fear conditioning memory in rats.
    Title: Deficiency of the RIβ subunit of protein kinase A causes body tremor and impaired fear conditioning memory in rats.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC125243

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cAMP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cAMP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables cAMP binding IEA
Inferred from Electronic Annotation
more info
  
enables cAMP-dependent protein kinase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cAMP-dependent protein kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables cAMP-dependent protein kinase regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cAMP-dependent protein kinase regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase A catalytic subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase A catalytic subunit binding IC
Inferred by Curator
more info
 PubMed 
enables protein kinase A catalytic subunit binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within learning or memory ISO
Inferred from Sequence Orthology
more info
  
involved_in modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cAMP-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of excitatory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of fear response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of synaptic vesicle cycle ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
  
part_of cAMP-dependent protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cAMP-dependent protein kinase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cAMP-dependent protein kinase complex IEA
Inferred from Electronic Annotation
more info
  
part_of cAMP-dependent protein kinase complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in hippocampal mossy fiber to CA3 synapse ISO
Inferred from Sequence Orthology
more info
  
located_in multivesicular body ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cAMP-dependent protein kinase type I-beta regulatory subunit
Names
cAMP dependent protein kinase, subunit type 1 beta
protein kinase cAMP-dependent type 1 regulatory subunit beta
protein kinase, cAMP dependent regulatory, type I, beta
protein kinase, cAMP-dependent, regulatory subunit type I beta
NP_001028851.2
NP_001405604.1
XP_038945043.1
XP_038945044.1
XP_038945045.1
XP_038945046.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033679.2 → NP_001028851.2  cAMP-dependent protein kinase type I-beta regulatory subunit isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    F1M9X5, Q3SWU5
    Related
    ENSRNOP00000033202.7, ENSRNOT00000031896.7
    Conserved Domains (2) summary
    COG0664
    Location:227 → 337
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:233 → 348
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

  2. NM_001418675.1 → NP_001405604.1  cAMP-dependent protein kinase type I-beta regulatory subunit isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/Swiss-Prot
    P81377

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    20606066..20738766
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039089117.2 → XP_038945045.1  cAMP-dependent protein kinase type I-beta regulatory subunit isoform X1

    UniProtKB/Swiss-Prot
    P81377
    UniProtKB/TrEMBL
    A0A8I6A184
    Conserved Domains (2) summary
    cd12102
    Location:11 → 64
    DD_RIbeta_PKA; Dimerization/Docking domain of the Type I beta Regulatory subunit of cAMP-dependent protein kinase
    cd00038
    Location:255 → 370
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

  2. XM_039089116.2 → XP_038945044.1  cAMP-dependent protein kinase type I-beta regulatory subunit isoform X1

    UniProtKB/Swiss-Prot
    P81377
    UniProtKB/TrEMBL
    A0A8I6A184
    Conserved Domains (2) summary
    cd12102
    Location:11 → 64
    DD_RIbeta_PKA; Dimerization/Docking domain of the Type I beta Regulatory subunit of cAMP-dependent protein kinase
    cd00038
    Location:255 → 370
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

  3. XM_039089115.2 → XP_038945043.1  cAMP-dependent protein kinase type I-beta regulatory subunit isoform X1

    UniProtKB/Swiss-Prot
    P81377
    UniProtKB/TrEMBL
    A0A8I6A184
    Related
    ENSRNOP00000083988.1
    Conserved Domains (2) summary
    cd12102
    Location:11 → 64
    DD_RIbeta_PKA; Dimerization/Docking domain of the Type I beta Regulatory subunit of cAMP-dependent protein kinase
    cd00038
    Location:255 → 370
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

  4. XM_039089118.2 → XP_038945046.1  cAMP-dependent protein kinase type I-beta regulatory subunit isoform X2

    UniProtKB/TrEMBL
    Q5BJR2
    Related
    ENSRNOP00000097684.1
    Conserved Domains (1) summary
    cd00038
    Location:103 → 218
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P81377.2 GenPept UniProtKB/Swiss-Prot:P81377

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