U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Mras muscle RAS oncogene homolog [ Rattus norvegicus (Norway rat) ]

Gene ID: 25482, updated on 13-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Mrasprovided by RGD
Official Full Name
muscle RAS oncogene homologprovided by RGD
Primary source
RGD:3111
See related
Ensembl:ENSRNOG00000014060 AllianceGenome:RGD:3111
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable GTP-dependent protein binding activity; GTPase activity; and guanyl ribonucleotide binding activity. Predicted to be involved in Ras protein signal transduction. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Noonan syndrome 11. Orthologous to human MRAS (muscle RAS oncogene homolog). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 116.5), Brain (RPKM 96.5) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
8q31
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (108823374..108886104, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (99944036..100006771, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (107629028..107656851, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C8, pseudogene 3 Neighboring gene centrosomal protein 70 Neighboring gene extended synaptotagmin 3 Neighboring gene uncharacterized LOC134480219 Neighboring gene NME/NM23 family member 9 Neighboring gene armadillo repeat containing 8

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Sustained activation of M-Ras induced by nerve growth factor is essential for neuronal differentiation of PC12 cells. Sun P, et al. Genes Cells, 2006 Sep. PMID 16923128
  2. Elucidation of MRAS-mediated Noonan syndrome with cardiac hypertrophy. Higgins EM, et al. JCI Insight, 2017 Mar 9. PMID 28289718, Free PMC Article
  3. Plexin-B1 is a GTPase activating protein for M-Ras, remodelling dendrite morphology. Saito Y, et al. EMBO Rep, 2009 Jun. PMID 19444311, Free PMC Article
  4. Novel small GTPase M-Ras participates in reorganization of actin cytoskeleton. Matsumoto K, et al. Oncogene, 1997 Nov 13. PMID 9395237
  5. Regulator of G-protein signaling 14 (RGS14) is a selective H-Ras effector. Willard FS, et al. PLoS One, 2009. PMID 19319189, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Plexin-B1 is a dual functional GTPase activating protein for R-Ras and M-Ras, remodelling axon and dendrite morphology, respectively.
    Title: Plexin-B1 is a GTPase activating protein for M-Ras, remodelling dendrite morphology.
  2. M-Ras is essential for neuronal differentiation in PC12 cells by inducing sustained activation of ERK pathway.
    Title: Sustained activation of M-Ras induced by nerve growth factor is essential for neuronal differentiation of PC12 cells.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein activity IEA
Inferred from Electronic Annotation
more info
  
enables GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP-dependent protein binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to leukemia inhibitory factor IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ras-related protein M-Ras
Names
muscle and microspikes RAS
ras-related protein R-Ras3
NP_001375430.1
NP_037113.2
XP_038936811.1
XP_038936812.1
XP_038936815.1
XP_063121019.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001388501.2 → NP_001375430.1  ras-related protein M-Ras

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    O09021, P97538
    UniProtKB/TrEMBL
    A0A0G2K389, A6I2D6, Q5RKJ7
    Conserved Domains (1) summary
    cd04145
    Location:12 → 176
    M_R_Ras_like; R-Ras2/TC21, M-Ras/R-Ras3

  2. NM_012981.3 → NP_037113.2  ras-related protein M-Ras

    See identical proteins and their annotated locations for NP_037113.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    O09021, P97538
    UniProtKB/TrEMBL
    A0A0G2K389, A6I2D6, Q5RKJ7
    Conserved Domains (1) summary
    cd04145
    Location:12 → 176
    M_R_Ras_like; R-Ras2/TC21, M-Ras/R-Ras3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    108823374..108886104 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039080887.1 → XP_038936815.1  ras-related protein M-Ras isoform X2

    UniProtKB/Swiss-Prot
    O09021, P97538
    UniProtKB/TrEMBL
    A0A0G2K389, A6I2D6, Q5RKJ7
    Related
    ENSRNOP00000085134.1, ENSRNOT00000118697.1
    Conserved Domains (1) summary
    cd04145
    Location:12 → 176
    M_R_Ras_like; R-Ras2/TC21, M-Ras/R-Ras3

  2. XM_039080884.1 → XP_038936812.1  ras-related protein M-Ras isoform X2

    UniProtKB/Swiss-Prot
    O09021, P97538
    UniProtKB/TrEMBL
    A0A0G2K389, A6I2D6, Q5RKJ7
    Related
    ENSRNOP00000072543.1, ENSRNOT00000077963.2
    Conserved Domains (1) summary
    cd04145
    Location:12 → 176
    M_R_Ras_like; R-Ras2/TC21, M-Ras/R-Ras3

  3. XM_063264949.1 → XP_063121019.1  ras-related protein M-Ras isoform X2

    UniProtKB/TrEMBL
    A0A0G2K389, A6I2D6, Q5RKJ7

  4. XM_039080883.2 → XP_038936811.1  ras-related protein M-Ras isoform X1

    UniProtKB/TrEMBL
    A0A8I6A109, F7FMZ0
    Related
    ENSRNOP00000045851.2
    Conserved Domains (1) summary
    cd04145
    Location:40 → 204
    M_R_Ras_like; R-Ras2/TC21, M-Ras/R-Ras3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97538.2 GenPept UniProtKB/Swiss-Prot:P97538

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous