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Cmklr2 chemerin chemokine-like receptor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25457, updated on 13-Apr-2024

Summary

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Official Symbol
Cmklr2provided by RGD
Official Full Name
chemerin chemokine-like receptor 2provided by RGD
Primary source
RGD:2728
See related
Ensembl:ENSRNOG00000045532 AllianceGenome:RGD:2728
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gpr1
Summary
Predicted to enable G protein-coupled receptor activity; adipokinetic hormone receptor activity; and peptide binding activity. Predicted to be involved in glucose homeostasis and neuropeptide signaling pathway. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be active in neuron projection. Predicted to be integral component of plasma membrane. Orthologous to human CMKLR2 (chemerin chemokine-like receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 5.5), Heart (RPKM 1.5) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cmklr2 in Genome Data Viewer
Location:
9q32
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (72077164..72111979, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (64583310..64617883, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (69958607..69991410, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORD51 Neighboring gene small nucleolar RNA SNORA41 Neighboring gene eukaryotic translation elongation factor 1 beta 2 Neighboring gene zinc finger, DBF-type containing 2 Neighboring gene cytochrome c oxidase subunit 5B, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mapping studies of two G protein-coupled receptor genes: an amino acid difference may confer a functional variation between a human and rodent receptor. Marchese A, et al. Biochem Biophys Res Commun, 1994 Dec 30. PMID 7811287
  2. Chemerin Elicits Potent Constrictor Actions via Chemokine-Like Receptor 1 (CMKLR1), not G-Protein-Coupled Receptor 1 (GPR1), in Human and Rat Vasculature. Kennedy AJ, et al. J Am Heart Assoc, 2016 Oct 14. PMID 27742615, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CMKLR1 and GPR1 were widely expressed in vascular smooth muscle.
    Title: Chemerin Elicits Potent Constrictor Actions via Chemokine-Like Receptor 1 (CMKLR1), not G-Protein-Coupled Receptor 1 (GPR1), in Human and Rat Vasculature.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adipokinetic hormone binding ISO
Inferred from Sequence Orthology
more info
  
enables adipokinetic hormone binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables adipokinetic hormone receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables adipokinetic hormone receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables neuropeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in glucose homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in glucose homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
chemerin-like receptor 2
Names
G protein-coupled receptor 1
G-protein copled receptor 1
chemokine-like receptor 2
probable G-protein coupled receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012961.2 → NP_037093.2  chemerin-like receptor 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    M0RCK7, P46090
    Related
    ENSRNOP00000067327.1, ENSRNOT00000072737.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    72077164..72111979 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063266682.1 → XP_063122752.1  chemerin-like receptor 2 isoform X1

    UniProtKB/Swiss-Prot
    M0RCK7, P46090

  2. XM_039083036.1 → XP_038938964.1  chemerin-like receptor 2 isoform X1

    UniProtKB/Swiss-Prot
    M0RCK7, P46090
    Conserved Domains (1) summary
    cd15119
    Location:39 → 313
    7tmA_GPR1; G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P46090.2 GenPept UniProtKB/Swiss-Prot:P46090

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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