U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Eno3 enolase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25438, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Eno3provided by RGD
Official Full Name
enolase 3provided by RGD
Primary source
RGD:2555
See related
Ensembl:ENSRNOG00000004078 AllianceGenome:RGD:2555
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
BBE; MSE
Summary
Enables identical protein binding activity and phosphopyruvate hydratase activity. Involved in aging; response to xenobiotic stimulus; and skeletal muscle tissue regeneration. Located in membrane. Biomarker of aortic valve stenosis. Orthologous to human ENO3 (enolase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 28374.5) See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
10q24
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (55868880..55876099)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (55370531..55375921)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (57278271..57283661)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ring finger protein 167 Neighboring gene profilin 1 Neighboring gene sperm associated antigen 7 Neighboring gene calmodulin binding transcription activator 2 Neighboring gene inhibitor of CDK, cyclin A1 interacting protein 1 Neighboring gene small nucleolar RNA U3

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Distribution of beta-enolase in normal and tumor rat cells. Seweryn E, et al. Folia Histochem Cytobiol, 2008. PMID 19141407
  2. Advanced glycation end-product accumulation and associated protein modification in type II skeletal muscle with aging. Snow LM, et al. J Gerontol A Biol Sci Med Sci, 2007 Nov. PMID 18000139
  3. Investigation of differentially expressed proteins in rat gastrocnemius muscle during denervation-reinnervation. Sun H, et al. J Muscle Res Cell Motil, 2006. PMID 16752196
  4. Tissue distribution, developmental profiles and effect of denervation of enolase isozymes in rat muscles. Kato K, et al. Biochim Biophys Acta, 1985 Jul 26. PMID 3893549
  5. cDNA cloning and nucleotide sequence of rat muscle-specific enolase (beta beta enolase). Ohshima Y, et al. FEBS Lett, 1989 Jan 2. PMID 2914621

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC93623

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphopyruvate hydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphopyruvate hydratase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphopyruvate hydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphopyruvate hydratase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in canonical glycolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in canonical glycolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
  
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in skeletal muscle tissue regeneration IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in substantia nigra development ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
part_of phosphopyruvate hydratase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of phosphopyruvate hydratase complex IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
beta-enolase
Names
2-phospho-D-glycerate hydro-lyase
Muscle specific enolase (beta beta enolose) (two splicing products)
enolase 3, beta, muscle
muscle-specific enolase
skeletal muscle enolase
NP_037081.2
XP_006246661.1
XP_006246662.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012949.2 → NP_037081.2  beta-enolase

    See identical proteins and their annotated locations for NP_037081.2

    Status: VALIDATED

    Source sequence(s)
    BC083566, DY321069
    UniProtKB/Swiss-Prot
    P15429, Q5XIV3
    UniProtKB/TrEMBL
    A0A8I5ZJD5, A6HG88
    Related
    ENSRNOP00000005612.4, ENSRNOT00000005612.7
    Conserved Domains (2) summary
    PLN00191
    Location:2 → 431
    PLN00191; enolase
    cd03313
    Location:5 → 415
    enolase; Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions.

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    55868880..55876099
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006246599.5 → XP_006246661.1  beta-enolase isoform X1

    See identical proteins and their annotated locations for XP_006246661.1

    UniProtKB/Swiss-Prot
    P15429, Q5XIV3
    UniProtKB/TrEMBL
    A0A8I5ZJD5, A6HG88
    Conserved Domains (2) summary
    PLN00191
    Location:2 → 431
    PLN00191; enolase
    cd03313
    Location:5 → 415
    enolase; Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions.

  2. XM_006246600.5 → XP_006246662.1  beta-enolase isoform X1

    See identical proteins and their annotated locations for XP_006246662.1

    UniProtKB/Swiss-Prot
    P15429, Q5XIV3
    UniProtKB/TrEMBL
    A0A8I5ZJD5, A6HG88
    Conserved Domains (2) summary
    PLN00191
    Location:2 → 431
    PLN00191; enolase
    cd03313
    Location:5 → 415
    enolase; Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P15429.3 GenPept UniProtKB/Swiss-Prot:P15429

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous