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Eef2k eukaryotic elongation factor-2 kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 25435, updated on 13-Apr-2024

Summary

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Official Symbol
Eef2kprovided by RGD
Official Full Name
eukaryotic elongation factor-2 kinaseprovided by RGD
Primary source
RGD:2538
See related
Ensembl:ENSRNOG00000016448 AllianceGenome:RGD:2538
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
SMEF2K
Summary
Enables elongation factor-2 kinase activity. Involved in several processes, including cellular response to anoxia; positive regulation of cellular component organization; and response to peptide hormone. Located in dendritic spine and postsynaptic density. Orthologous to human EEF2K (eukaryotic elongation factor 2 kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 171.7), Heart (RPKM 69.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Eef2k in Genome Data Viewer
Location:
1q36
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (184824420..184888048)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (175393119..175456756)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (190780211..190839926)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene short chain dehydrogenase/reductase family 42E, member 2 Neighboring gene transfer RNA leucine (anticodon UAG) 1 Neighboring gene uncharacterized LOC102556194 Neighboring gene transfer RNA leucine (anticodon AAG) 1 Neighboring gene RNA polymerase III subunit E

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Eukaryotic elongation factor 2 kinase inhibitor, A484954 inhibits perivascular sympathetic nerve stimulation-induced vasoconstriction in isolated renal artery. Kodama T, et al. Eur J Pharmacol, 2022 Jul 5. PMID 35598844
  2. Age-dependent increase in activity of eukaryotic elongation factor 2 kinase in mesenteric arteries from spontaneously hypertensive rats. Kodama T, et al. J Vet Med Sci, 2021 Jan 14. PMID 33191388, Free PMC Article
  3. Eukaryotic elongation factor 2 (eEF2) kinase/eEF2 plays protective roles against glucose deprivation-induced cell death in H9c2 cardiomyoblasts. Kameshima S, et al. Apoptosis, 2019 Apr. PMID 30737648
  4. Intrauterine growth restriction inhibits expression of eukaryotic elongation factor 2 kinase, a regulator of protein translation. McKnight RA, et al. Physiol Genomics, 2016 Aug 1. PMID 27317589
  5. Characterization of the role of microtubule-associated protein 1B in metabotropic glutamate receptor-mediated endocytosis of AMPA receptors in hippocampus. Davidkova G, et al. J Neurosci, 2007 Nov 28. PMID 18045921, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Eukaryotic elongation factor 2 kinase inhibitor, A484954 inhibits perivascular sympathetic nerve stimulation-induced vasoconstriction in isolated renal artery.
    Title: Eukaryotic elongation factor 2 kinase inhibitor, A484954 inhibits perivascular sympathetic nerve stimulation-induced vasoconstriction in isolated renal artery.
  2. Age-dependent increase in activity of eukaryotic elongation factor 2 kinase in mesenteric arteries from spontaneously hypertensive rats.
    Title: Age-dependent increase in activity of eukaryotic elongation factor 2 kinase in mesenteric arteries from spontaneously hypertensive rats.
  3. NMDA-induced nitric oxide generation and CREB activation in central nervous system is dependent on eukaryotic elongation factor 2 kinase.
    Title: NMDA-induced nitric oxide generation and CREB activation in central nervous system is dependent on eukaryotic elongation factor 2 kinase.
  4. EEF2K/eEF2 axis under GD condition mediates the inhibition of apoptotic H9c2 cell death.
    Title: Eukaryotic elongation factor 2 (eEF2) kinase/eEF2 plays protective roles against glucose deprivation-induced cell death in H9c2 cardiomyoblasts.
  5. HSP70 also interacted with C-terminal fragment of eEF2, which could reverse the nucleus translocation and cardiomyocyte apoptosis caused by N-terminal fragment of eEF2. HSP70 draw on advantage and avoid defect of MIR through regulating phosphorylation and nucleus translocation of eEF2
    Title: Heat shock protein 70 protects cardiomyocytes through suppressing SUMOylation and nucleus translocation of phosphorylated eukaryotic elongation factor 2 during myocardial ischemia and reperfusion.
  6. The eEF2K promotor in IUGR offspring also lost the protective histone covalent modifications associated with unmethylated CGIs.
    Title: Intrauterine growth restriction inhibits expression of eukaryotic elongation factor 2 kinase, a regulator of protein translation.
  7. Using an eEF2K gain-of-function design in vitro as well as eEF2K-KO mice, we show that eEF2K activity regulates the excitation/inhibition balance by downregulating vesicle release at inhibitory synapses and tonic inhibition. This translates into a reduced susceptibility of eEF2K-KO mice for seizures without major behavioral alterations with the exception of impaired contextual and trace fear memory
    Title: eEF2K/eEF2 Pathway Controls the Excitation/Inhibition Balance and Susceptibility to Epileptic Seizures.
  8. Eukaryotic elongation factor 2 kinase regulates the development of hypertension through oxidative stress-dependent vascular inflammation.
    Title: Eukaryotic elongation factor 2 kinase regulates the development of hypertension through oxidative stress-dependent vascular inflammation.
  9. Expression of betaTRCP1 increases the polyubiquitylation of EEF2K in PC12 cells.
    Title: Proteasomal degradation of eukaryotic elongation factor-2 kinase (EF2K) is regulated by cAMP-PKA signaling and the SCFβTRCP ubiquitin E3 ligase.
  10. A Ca(2+)-calmodulin-eEF2K-eEF2 signalling cascade, but not AMPK, contributes to the suppression of skeletal muscle protein synthesis during contractions.
    Title: A Ca(2+)-calmodulin-eEF2K-eEF2 signalling cascade, but not AMPK, contributes to the suppression of skeletal muscle protein synthesis during contractions.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
  
enables calmodulin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables elongation factor-2 kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables elongation factor-2 kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables elongation factor-2 kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to anoxia IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to brain-derived neurotrophic factor stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to cAMP IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to calcium ion IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to insulin stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in myosin II filament disassembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of dendritic spine morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of synapse assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of translation at postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of translation at postsynapse IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in regulation of translation at postsynapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to ischemia IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to prolactin IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in dendritic spine IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
eukaryotic elongation factor 2 kinase
Names
calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase
eEF-2 kinase
eEF-2K
elongation factor 2 kinase
eukaroytic elongation factor 2 kinase
NP_037079.1
XP_006230219.1
XP_006230220.1
XP_038957666.1
XP_063137875.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012947.3 → NP_037079.1  eukaryotic elongation factor 2 kinase

    See identical proteins and their annotated locations for NP_037079.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    O09089, P70531
    UniProtKB/TrEMBL
    A6I8S8, Q6P757
    Related
    ENSRNOP00000022726.3, ENSRNOT00000022726.6
    Conserved Domains (3) summary
    smart00811
    Location:120 → 317
    Alpha_kinase; Alpha-kinase family
    COG0790
    Location:545 → 645
    TPR; TPR repeat [Signal transduction mechanisms]
    sd00010
    Location:502 → 535
    SLR; SLR repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    184824420..184888048
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039101738.2 → XP_038957666.1  eukaryotic elongation factor 2 kinase isoform X2

    UniProtKB/TrEMBL
    Q6P757
    Conserved Domains (3) summary
    COG0790
    Location:475 → 575
    TPR; TPR repeat [Signal transduction mechanisms]
    sd00010
    Location:432 → 465
    SLR; SLR repeat [structural motif]
    cl28917
    Location:102 → 247
    Alpha_kinase; Alpha kinase family

  2. XM_006230157.5 → XP_006230219.1  eukaryotic elongation factor 2 kinase isoform X1

    See identical proteins and their annotated locations for XP_006230219.1

    UniProtKB/Swiss-Prot
    O09089, P70531
    UniProtKB/TrEMBL
    A6I8S8, Q6P757
    Conserved Domains (3) summary
    smart00811
    Location:120 → 317
    Alpha_kinase; Alpha-kinase family
    COG0790
    Location:545 → 645
    TPR; TPR repeat [Signal transduction mechanisms]
    sd00010
    Location:502 → 535
    SLR; SLR repeat [structural motif]

  3. XM_006230158.5 → XP_006230220.1  eukaryotic elongation factor 2 kinase isoform X1

    See identical proteins and their annotated locations for XP_006230220.1

    UniProtKB/Swiss-Prot
    O09089, P70531
    UniProtKB/TrEMBL
    A6I8S8, Q6P757
    Conserved Domains (3) summary
    smart00811
    Location:120 → 317
    Alpha_kinase; Alpha-kinase family
    COG0790
    Location:545 → 645
    TPR; TPR repeat [Signal transduction mechanisms]
    sd00010
    Location:502 → 535
    SLR; SLR repeat [structural motif]

  4. XM_063281805.1 → XP_063137875.1  eukaryotic elongation factor 2 kinase isoform X1

    UniProtKB/Swiss-Prot
    O09089, P70531
    UniProtKB/TrEMBL
    A6I8S8
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70531.1 GenPept UniProtKB/Swiss-Prot:P70531

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