Cyp7a1 cytochrome P450 family 7 subfamily A member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cyp7a1provided by RGD
Official Full Name: cytochrome P450 family 7 subfamily A member 1provided by RGD
Primary source: RGD:2482
See related: Ensembl:ENSRNOG00000009488 AllianceGenome:RGD:2482
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CHAP; CYP7; CYP7S1
Summary: Enables cholesterol 7-alpha-monooxygenase activity. Involved in several processes, including bile acid biosynthetic process; cellular response to cholesterol; and regulation of lipid biosynthetic process. Located in intracellular membrane-bounded organelle. Biomarker of alcoholic hepatitis; cholestasis; extrahepatic cholestasis; and non-alcoholic steatohepatitis. Orthologous to human CYP7A1 (cytochrome P450 family 7 subfamily A member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 688.7) See more
Orthologs: human mouse all
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Genomic context

Location:: 5q12

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (24174505..24184202, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (19376979..19386676, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (19358734..19368431, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The increased CDCAs concentrations activated Fxr-Fgf15 pathway in ileum to result in the mRNA expression of Cyp7a1 in liver down-regulation, which inhibited cholesterol metabolizing into primary BAs to contribute to the cholesterol level increase in liver tissue in HFD-induced obesity rats.
Title: Hepatic cholesterol accumulation ascribed to the activation of ileum Fxr-Fgf15 pathway inhibiting hepatic Cyp7a1 in high-fat diet-induced obesity rats.
It has been demonstrated that hepatic gene expression of Cyp7a1 is directed by day/night rhythm but not daily rhythm in food intake. Combining an high-fat diet with feeding in the light/inactive period annulled CYp7a1 gene expression rhythms.
Title: Complex interaction between circadian rhythm and diet on bile acid homeostasis in male rats.
lnc-HC negatively regulates cholesterol metabolism within hepatocytes through physical interaction with hnRNPA2B1. By further binding to the target messenger RNA of Cyp7a1 or Abca1, the lnc-HC-hnRNPA2B1 complex decreases expressions of the two genes that are implicated in cellular cholesterol excretion.
Title: A novel long noncoding RNA Lnc-HC binds hnRNPA2B1 to regulate expressions of Cyp7a1 and Abca1 in hepatocytic cholesterol metabolism.
Administration of glucocorticoids (GCs) enhanced liver bile acid uptake by increasing the expression of the major hepatocyte basolateral bile transporter (Ntcp) in rats. The reduced expression of a bile acid synthesis rate-controlling enzyme, Cyp7a1, suggests that treatment with GCs suppressed hepatic bile acid synthesis.
Title: Glucocorticoid treatment alters systemic bile acid homeostasis by regulating the biosynthesis and transport of bile salts.
Dietary fats and glucomannan plus spirulina added to pork significantly alters Cyp7a1 expression in Zucker rats.
Title: Glucomannan and glucomannan plus spirulina added to pork significantly block dietary cholesterol effects on lipoproteinemia, arylesterase activity, and CYP7A1 expression in Zucker fa/fa rats.
Ginsenosides promoted liver cholesterol metabolism due to upregulation of CYP7A1.
Title: Increased effects of ginsenosides on the expression of cholesterol 7α-hydroxylase but not the bile salt export pump are involved in cholesterol metabolism.
Portal blood FGF15/19 levels remain unchanged while the corresponding ileal mRNA and liver CYP7A1 levels change significantly in cholesterol fed rats.
Title: FGF15/19 protein levels in the portal blood do not reflect changes in the ileal FGF15/19 or hepatic CYP7A1 mRNA levels.
Capsaicinoids consumption down-regulated the mRNA levels of HMG-CoA reductase and CYP7A1 in the cholesterol-free diet group but up-regulated the CYP7A1 level in the cholesterol-enriched diet group.
Title: Hypocholesterolemic effect of capsaicinoids in rats fed diets with or without cholesterol.
study shows ability of EGCG to raise plasma bile acid concentrations, mainly through Cyp7a1 upregulation, and to decrease bile production through reduction in Mrp2-mediated bile acid-independent bile flow
Title: Cholestatic effect of epigallocatechin gallate in rats is mediated via decreased expression of Mrp2.
insulin-dependent suppression results in impairment of the hepatic cholesterol/bile acid metabolisms
Title: Insulin-dependent suppression of cholesterol 7α-hydroxylase is a possible link between glucose and cholesterol metabolisms.

Submit: New GeneRIF Correction See all GeneRIFs (25)

General gene information

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Markers

D5Wox31 (e-PCR)
- UniSTS:239935

RH141579 (e-PCR)
- UniSTS:223573

PMC165443P1 (e-PCR)
- UniSTS:271538

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 24-hydroxycholesterol 7alpha-hydroxylase activity	IEA Inferred from Electronic Annotation more info
enables cholesterol 7-alpha-monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cholesterol 7-alpha-monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables cholesterol 7-alpha-monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in bile acid and bile salt transport	IEP Inferred from Expression Pattern more info	PubMed
involved_in bile acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in bile acid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in bile acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in bile acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in bile acid biosynthetic process	TAS Traceable Author Statement more info	PubMed
involved_in bile acid signaling pathway	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to cholesterol	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucose stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cholesterol catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in cholesterol catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cholesterol catabolic process	ISO Inferred from Sequence Orthology more info
involved_in cholesterol homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of collagen biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of fatty acid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cholesterol biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of bile acid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of bile acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cytochrome P450 7A1

Names: 24-hydroxycholesterol 7-alpha-hydroxylase; CYPVII; cholesterol 7-alpha-hydroxylase; cholesterol 7-alpha-monooxygenase; cytochrome P450 (cholesterol hydroxylase 7 alpha); cytochrome P450, 7a1; cytochrome P450, family 7, subfamily a, polypeptide 1

NP_037074.1

EC 1.14.14.23

EC 1.14.14.26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.